Francis Gigliotti, M.D.

Francis Gigliotti, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 690
Rochester, NY 14642

Office: (585) 275-5944
Fax: (585) 273-1104
Lab: (585) 275-5099

Research Bio

Dr. Gigliotti's research interests are:

1) Pneumocystis carinii pneumonia
2) Infections in the immunocompromised host
3) Inflammatory lung injury
4) Opportunistic infections.

Pneumocystis carinii is a life-threatening cause of pneumonitis among patients who are immunocompromised because of malignancies, AIDS, or congenital immunodeficiency disorders. P. carinii pneumonia also occurs in children who are immunocompromised on the basis of malnutrition; thus the global significance of P. carinii pneumonia is potentially great. However, because this organism is difficult to work with and because it cannot be cultivated outside an animal host, almost nothing is known about its biology.

The focus of Dr. Gigliotti's laboratory is elucidating the immunopathogenesis of P. carinii pneumonia. A major area of investigation relates to studying active and passive immunity to P. carinii. This work involves production of monoclonal antibodies, cloning of P. carinii genes (in collaboration with Dr. C.G. Haidaris and Dr. P.J. Haidaris, Departments of Microbiology and Immunology and of Medicine), and extensive use of animal models of P. carinii pneumonia.

The second major area of emphasis is the study of lung injury resulting from immune-mediated inflammation in response to infection with P. carinii. Together with Dr. Terry Wright, we are trying to develop means to manipulate this inflammatory process so as to decrease the morbidity and mortality associated with P. carinii pneumonia. It is hoped that these studies will lead to a better understanding of this organism and host-parasite interactions, which in turn will result in better means of prevention, diagnosis, and treatment of P. carinii pneumonia.

Awards & Honors (Local)

Best Doctor's in America 2008 - Present
American's Top Pediatricians 2007 - Present
Lindsey Distinguished Professorship for Pediatric Research | University of Rochester Medical Center-Department of Pediatrics 2007
Ruth A. Lawrence Faculty Service Award for Research 2006
Elected to American Society for Clinical Investigation 1995
Lowell Glasgow Dean's Teaching Scholar 1992 - 1995
House Staff Teaching Award 1989


Passive Intranasal Monoclonal Antibody Prophylaxis Against Murine Pneumocystis Carinii Pneumonia

United States Serial NO.: 10/584,871
Filed Date: December 31, 2004
Title: Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
Invented by: Francis Gigliotti, Terry Wright, Constantine Haidaris, Patricia Simpson-Haidaris
Polypeptides Capable of Inducing Antibodies against Pneumocystis Pathogens

United States Serial NO.: 14/237,133
Filed Date: August 6, 2012
Title: Optimized Antigens of Pneumocystis and Use Thereof
Invented by: Francis Gigliotti

Recent Journal Articles

Showing the 5 most recent journal articles. 109 available »

2015 Jun
Mischler M, Ryan MS, Leyenaar JK, Markowsky A, Seppa M, Wood K, Ren J, Asche C, Gigliotti F, Biondi E. "Epidemiology of Bacteremia in Previously Healthy Febrile Infants: A Follow-up Study." Hospital pediatrics. 2015 Jun; 5(6):293-300.
2014 Nov 3
Gigliotti F, Limper AH, Wright T. "Pneumocystis." Cold Spring Harbor perspectives in medicine. 2014 Nov 3; 4(12):a019828. Epub 2014 Nov 03.
2014 Sep
Kainth MK, Gigliotti F. "Simultaneous testing of erythrocyte sedimentation rate and C-reactive protein: increased expenditure without demonstrable benefit." The Journal of pediatrics. 2014 Sep; 165(3):625-7. Epub 2014 Jun 21.
2014 Jan 1
Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW. "MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Jan 1; 192(1):282-92. Epub 2013 Nov 29.
2013 Nov 1
Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW. "Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis." The Journal of immunology : official journal of the American Association of Immunologists. 2013 Nov 1; 191(9):4720-30. Epub 2013 Sep 27.

Current Appointments

Lindsey Distinguished Professorship for Pediatric Research - Department of Pediatrics (SMD)
Professor - Department of Pediatrics, Infectious Diseases (SMD) - Primary
Professor - Department of Microbiology and Immunology (SMD)


Infectious Disease - American Board of Pediatrics
Pediatrics - American Board of Pediatrics


MD | Medicine | University of Virginia School of Medicine1977
AB | Biology | West Virginia University1974

Post-Doctoral Training & Residency

Fellowship in Pediatric Infectious Disease at University of Rochester Medical Center07/01/1980 - 06/30/1983
Residency in Pediatrics at University of Virginia School of Medicine07/01/1978 - 06/30/1980
Internship in Pediatrics at University of Virginia School of Medicine07/01/1977 - 06/30/1978