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Francis Gigliotti, M.D.

Pediatrics

Clinical Interests

Infectious Diseases

Contact Information

Phone Numbers

Appointment: (585) 275-5944

Fax: (585) 273-1104

Office: (585) 275-5944

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Pediatric infectious diseases, especially infections in the immunocompromised host.

Research

Dr. Gigliotti's research interests are: 1) Pneumocystis carinii pneumonia 2) Infections in the immunocompromised host 3) Inflammatory lung injury 4) Opportunistic infections. Pneumocystis carinii is a life-threatening cause of pneumonitis among patients who are immunocompromised because of malignancies, AIDS, or congenital immunodeficiency disorders. P. carinii pneumonia also occurs in children who are immunocompromised on the basis of malnutrition; thus the global significance of P. carinii pneumonia is potentially great. However, because this organism is difficult to work with and because it cannot be cultivated outside an animal host, almost nothing is known about its biology. The focus of Dr. Gigliotti's laboratory is elucidating the immunopathogenesis of P. carinii pneumonia. A major area of investigation relates to studying active and passive immunity to P. carinii. This work involves production of monoclonal antibodies, cloning of P. carinii genes (in collaboration with Dr. C.G. Haidaris and Dr. P.J. Haidaris, Departments of Microbiology and Immunology and of Medicine), and extensive use of animal models of P. carinii pneumonia. The second major area of emphasis is the study of lung injury resulting from immune-mediated inflammation in response to infection with P. carinii. Together with Dr. Terry Wright, we are trying to develop means to manipulate this inflammatory process so as to decrease the morbidity and mortality associated with P. carinii pneumonia. It is hoped that these studies will lead to a better understanding of this organism and host-parasite interactions, which in turn will result in better means of prevention, diagnosis, and treatment of P. carinii pneumonia.

Credentials

Faculty Appointments

Specialties

  • Infectious Disease - American Board of Pediatrics
  • Pediatrics - American Board of Pediatrics

Education

1974
AB | West Virginia University
Biology

1977
MD | University of Virginia School of Medicine
Medicine

Post-doctoral Training & Residency

07/01/1977 - 06/30/1978
Internship in Pediatrics at University of Virginia School of Medicine

07/01/1978 - 06/30/1980
Residency in Pediatrics at University of Virginia School of Medicine

07/01/1980 - 06/30/1983
Fellowship in Pediatrics: Pediatric Infectious Diseases at University of Rochester Medical Center

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Awards

2008 - Present
Best Doctor's in America

2007 - Present
American's Top Pediatricians

2007
Lindsey Distinguished Professorship for Pediatric Research
Sponsor: University of Rochester Medical Center-Department of Pediatrics

2006
Ruth A. Lawrence Faculty Service Award for Research

1995
Elected to American Society for Clinical Investigation

1992 - 1995
Lowell Glasgow Dean's Teaching Scholar

1989
House Staff Teaching Award

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Patents

Title: Optimized Antigens of Pneumocystis and Use Thereof
U.S. Serial #: 14/237,133
Filed: Aug 06, 2012
Invented By: FrancisGigliotti

Title: Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
U.S. Serial #: 10/584,871
Filed: Dec 31, 2004
Invented By: FrancisGigliotti, ConstantineHaidaris, PatriciaSimpson-Haidaris, TerryWright

Publications

Journal Articles

4/2017
Tesini BL, Wright TW, Malone JE, Haidaris CG, Harber M, Sant AJ, Nayak JL, Gigliotti F. "Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii." Infection and immunity.. 2017 Apr 0; 85(4)Epub 2017 Mar 23.

12/2016
Chemello G, Piccinetti C, Randazzo B, Carnevali O, Maradonna F, Magro M, Bonaiuto E, Vianello F, Radaelli G, Fifi AP, Gigliotti F, Olivotto I. "Oxytetracycline Delivery in Adult Female Zebrafish by Iron Oxide Nanoparticles." Zebrafish.. 2016 Dec 0; 13(6):495-503. Epub 2016 Aug 10.

12/2015
Zhang ZQ, Wang J, Hoy Z, Keegan A, Gigliotti F, Wright T. "Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome." Infection and immunity.. 2015 Dec 0; 83(12):4594-603. Epub 2015 Sep 14.

Books & Chapters

2015
Chapter Title: Pneumocystis and Other Less Common
Book Title: Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant
Author List: Gigliotti F, Wright TW, Krysan
Published By: Elsevier Saunders2015 in Phildelphia

2015
Chapter Title: Pneumocystis pneumonia
Book Title: Feigin and Cherry's Textbook of Pediatric Infectious Disases
Author List: Gigliotti F
Published By: Elsevier Saunders2015 in Philadelphia

2015
Chapter Title: Pneumocystis Jirovecii
Book Title: Principles and Practice of Pediatric Infectious Diseases
Author List: Gigliotti, F
Published By: Saunders2015 in Philadelphia

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