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Carl J. Johnston, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5948

Biography

Research

Dr. Carl Johnston's work seeks to understand how the postnatal lung copes with external stress. A critical biological factor that plays a role in childhood pulmonary susceptibility is that a significant portion of lung development takes place postnatally. One of the environmental factors relevant to developmental lung disease is the recent increase in complexity and distribution, if not the levels, of airborne pollutants, including allergens and endotoxins, respirable particulate matter and irritant gases, exposure to which damages various cell types. Among the most important of these are the respiratory epithelium and critical immune effector cell populations. Furthermore; combined exposures to multiple pollutants may activate several unique signaling pathways which are age dependent and depending on the sequence of initiation may result in responses not predicted by evaluating exposures to an individual pollutant. His work depends heavily on mRNA analysis, microarray technology, immuno-histochemistry and in situ hybridization. This work is supported by participation in several NIH grants.

Credentials

Faculty Appointments

Education

1987
BA | Buffalo State College
Biology

1993
MS | University of Rochester
Toxicology

2006
PhD | SUNY at Buffalo
Pharmacology and Toxicology

Awards

2012
SOT Meeting, Outstanding Presentation – Mixtures Specialty Section

Publications

Journal Articles

4/2017
Beach TA, Johnston CJ, Groves AM, Williams JP, Finkelstein JN. "Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes." Experimental lung research.. 2017 Apr 0; 43(3):134-149. Epub 2017 May 23.

12/2016
Groves AM, Johnston CJ, Misra RS, Williams JP, Finkelstein JN. "Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation." International journal of radiation biology.. 2016 Dec 0; 92(12):754-765. Epub 2016 Sep 15.

2016
Williams JP, Johnston CJ, Misra R, Finkelstein JN, Groves A. "Thoracic Radiation Differentially Affects T Cells in Mediastinal Lymph Nodes of Fibrosis Sensitive and Resistant Mice." Int J Radiat Oncol Biol Phys. 2016; : 96(2S):S66-S67.

Books & Chapters

1998
Chapter Title: Ambient ultrafine particles: Inducers of acute injury?
Book Title: Relationships between respiratory disease and exposure to air pollution
Author List: Oberdörster G, Gelein R, Johnston C, Mercer P, Corson N, Finkelstein J.
Edited By: Dungworth et al, U Mohr
Published By: ILSI Monographs, ILSI press1998 in Washington, DC

1998
Chapter Title: Identification and characterization of a novel phosphatase with a role in the growth plate chondrocyte maturation
Book Title: Skeletal growth and development
Author List: Reynolds PR, Romano PR, Chi H, Wang J, Reynolds SD, Johnston C, Leboy PS, Tiller GE, Dasouk MJ, O'Keefe RJ, Puzas E, Rosier RN
Edited By: JA Buckwalter, MG Ehrlich, LJ Sandell, SB Tripped
Published By: American Academy of Orthopaedic Surgeons1998 in Rosemont, IL

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