Harold C. Smith, Ph.D.

Harold C. Smith, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-4267
Fax: (585) 275-6007
Lab: (585) 275-1882

Journal Articles

Showing all 99 journal articles available.

2016 Dec
Bennett RP, Stewart RA, Hogan PA, Ptak RG, Mankowski MK, Hartman TL, Buckheit RW, Snyder BA, Salter JD, Morales GA, Smith HC. "An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation." Antiviral research. 2016 Dec; 136:51-59. Epub 2016 Nov 05.
2016 Nov 21
Smith HC. "RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing." RNA biology. 2016 Nov 21; :1-13. Epub 2016 Nov 21.
2016 Sep 1
Polevoda B, McDougall WM, Bennett RP, Salter JD, Smith HC. "Structural and functional assessment of APOBEC3G macromolecular complexes." Methods : a companion to Methods in enzymology. 2016 Sep 1; 107:10-22. Epub 2016 Mar 14.
2016 Jul
Salter JD, Bennett RP, Smith HC. "The APOBEC Protein Family: United by Structure, Divergent in Function." Trends in biochemical sciences. 2016 Jul; 41(7):578-94. Epub 2016 Jun 06.
2016 Jan 15
Hilimire TA, Bennett RP, Stewart RA, Garcia-Miranda P, Blume A, Becker J, Sherer N, Helms ED, Butcher SE, Smith HC, Miller BL. "N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA." ACS chemical biology. 2016 Jan 15; 11(1):88-94. Epub 2015 Nov 03.
2015 Oct 30
Polevoda B, McDougall WM, Tun BN, Cheung M, Salter JD, Friedman AE, Smith HC. "RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates." Nucleic acids research. 2015 Oct 30; 43(19):9434-45. Epub 2015 Sep 30.
2014 Sep
Salter JD, Morales GA, Smith HC. "Structural insights for HIV-1 therapeutic strategies targeting Vif." Trends in biochemical sciences. 2014 Sep; 39(9):373-80. Epub 2014 Aug 12.
2014 Feb 13
Ofori LO, Hilimire TA, Bennett RP, Brown NW, Smith HC, Miller BL. "High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity." Journal of medicinal chemistry. 2014 Feb 13; 57(3):723-32. Epub 2014 Jan 15.
Prohaska KM, Bennett RP, Salter JD, Smith HC. "The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions." Wiley interdisciplinary reviews. RNA. 2014 5(4):493-508. Epub 2014 Mar 24.
2012 May
Smith HC, Bennett RP, Kizilyer A, McDougall WM, Prohaska KM. "Functions and regulation of the APOBEC family of proteins." Seminars in cell & developmental biology. 2012 May; 23(3):258-68. Epub 2011 Oct 06.
2011 Sep 9
McDougall WM, Smith HC. "Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity." Biochemical and biophysical research communications. 2011 Sep 9; 412(4):612-7. Epub 2011 Aug 11.
2011 Sep 2
McDougall WM, Okany C, Smith HC. "Deaminase activity on single-stranded DNA (ssDNA) occurs in vitro when APOBEC3G cytidine deaminase forms homotetramers and higher-order complexes." The Journal of biological chemistry. 2011 Sep 2; 286(35):30655-61. Epub 2011 Jul 07.
2011 May
Smith HC. "APOBEC3G: a double agent in defense." Trends in biochemical sciences. 2011 May; 36(5):239-44. Epub 2011 Jan 14.
2010 Nov
Galloway CA, Ashton J, Sparks JD, Mooney RA, Smith HC. "Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes." Biochimica et biophysica acta. 2010 Nov; 1802(11):976-85. Epub 2010 Jun 09.
2010 Jul 16
Galloway CA, Kumar A, Krucinska J, Smith HC. "APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers." Biochemical and biophysical research communications. 2010 Jul 16; 398(1):38-43. Epub 2010 Jun 10.
2010 Jan 1
Galloway CA, Smith HC. "The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells." Biochemical and biophysical research communications. 2010 Jan 1; 391(1):659-63. Epub 2009 Nov 20.
2009 Nov 17
Salter JD, Krucinska J, Raina J, Smith HC, Wedekind JE. "A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function." Biochemistry. 2009 Nov 17; 48(45):10685-7.
2008 Nov 28
Bennett RP, Salter JD, Liu X, Wedekind JE, Smith HC. "APOBEC3G subunits self-associate via the C-terminal deaminase domain." The Journal of biological chemistry. 2008 Nov 28; 283(48):33329-36. Epub 2008 Oct 08.
2008 Mar 21
Bennett RP, Presnyak V, Wedekind JE, Smith HC. "Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding." The Journal of biological chemistry. 2008 Mar 21; 283(12):7320-7. Epub 2007 Dec 28.
Smith, H. C.;. "RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems". (H.C. Smith, ed) 16 chapters, Wiley Press, NY, 2008. 2008; . Link
2007 Nov 24
Miller JH, Presnyak V, Smith HC. "The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G." Retrovirology. 2007 Nov 24; 4:81. Epub 2007 Nov 24.
2007 Mar
Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. "Functional characterization of APOBEC-1 complementation factor phosphorylation sites." Biochimica et biophysica acta. 2007 Mar; 1773(3):408-18. Epub 2006 Dec 08.
Jin, X.; Wu, H.; Smith, H.C.;. "APOBEC3G levels predict rates of progression to AIDS". Retrovirology. 2007; 4(3): 20-7. Link
Miller, H. J.; Presnyak, V.; Smith, H.C.;. "The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G". Retrovirology. 2007; 4(3): 81-91. Link
Smith HC. "Measuring editing activity and identifying cytidine-to-uridine mRNA editing factors in cells and biochemical isolates." Methods in enzymology. 2007 424:389-416.
2006 Dec 15
Wedekind JE, Gillilan R, Janda A, Krucinska J, Salter JD, Bennett RP, Raina J, Smith HC. "Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits." The Journal of biological chemistry. 2006 Dec 15; 281(50):38122-6. Epub 2006 Oct 31.
2006 Nov 10
Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. "APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic." Biochemical and biophysical research communications. 2006 Nov 10; 350(1):214-9. Epub 2006 Sep 18.
2006 Jul 1
Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A. "Structural phylogenetic analysis of activation-induced deaminase function." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Jul 1; 177(1):355-61.
Lehmann DM, Galloway CA, Sowden MP, Smith HC. "Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor." Nucleic acids research. 2006 34(11):3299-308. Epub 2006 Jul 04.
2005 Sep
Jin X, Brooks A, Chen H, Bennett R, Reichman R, Smith H. "APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremia." Journal of virology. 2005 Sep; 79(17):11513-6.
2004 Jun
Smith HC, Bottaro A, Sowden MP, Wedekind JE. "Activation induced deaminase: the importance of being specific." Trends in genetics : TIG. 2004 Jun; 20(6):224-7.
2004 May 25
Xie K, Sowden MP, Dance GS, Torelli AT, Smith HC, Wedekind JE. "The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1." Proceedings of the National Academy of Sciences of the United States of America. 2004 May 25; 101(21):8114-9. Epub 2004 May 17.
2004 Jan 2
Sowden MP, Lehmann DM, Lin X, Smith CO, Smith HC. "Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing." The Journal of biological chemistry. 2004 Jan 2; 279(1):197-206. Epub 2003 Oct 21.
2003 Apr
Wedekind JE, Dance GS, Sowden MP, Smith HC. "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." Trends in genetics : TIG. 2003 Apr; 19(4):207-16.
2003 Mar
Galloway CA, Sowden MP, Smith HC. "Increasing the yield of soluble recombinant protein expressed in E. coli by induction during late log phase." BioTechniques. 2003 Mar; 34(3):524-6, 528, 530.
2002 Dec
Smith HC. "A course director's perspectives on problem-based learning curricula in biochemistry." Academic medicine : journal of the Association of American Medical Colleges. 2002 Dec; 77(12 Pt 1):1189-98.
2002 Apr 12
Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC. "Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing." The Journal of biological chemistry. 2002 Apr 12; 277(15):12703-9. Epub 2002 Jan 28.
2002 Mar 1
Sowden MP, Ballatori N, Jensen KL, Reed LH, Smith HC. "The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors." Journal of cell science. 2002 Mar 1; 115(Pt 5):1027-39.
2002 Feb
Yang Y, Ballatori N, Smith HC. "Apolipoprotein B mRNA editing and the reduction in synthesis and secretion of the atherogenic risk factor, apolipoprotein B100 can be effectively targeted through TAT-mediated protein transduction." Molecular pharmacology. 2002 Feb; 61(2):269-76.
2001 Dec 21
Giangreco A, Sowden MP, Mikityansky I, Smith HC. "Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis." Biochemical and biophysical research communications. 2001 Dec 21; 289(5):1162-7.
2001 Nov 1
Sowden MP, Smith HC. "Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization." The Biochemical journal. 2001 Nov 1; 359(Pt 3):697-705.
2001 Jul 15
Yang Y, Sowden MP, Yang Y, Smith HC. "Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA." Experimental cell research. 2001 Jul 15; 267(2):153-64.
2001 Apr 15
Dance GS, Beemiller P, Yang Y, Mater DV, Mian IS, Smith HC. "Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase." Nucleic acids research. 2001 Apr 15; 29(8):1772-80.
2000 Jul 28
Yang Y, Sowden MP, Smith HC. "Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1." The Journal of biological chemistry. 2000 Jul 28; 275(30):22663-9.
2000 Jan 15
Dance GS, Sowden MP, Yang Y, Smith HC. "APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast." Nucleic acids research. 2000 Jan 15; 28(2):424-9.
1999 Oct 10
Siddiqui JF, Van Mater D, Sowden MP, Smith HC. "Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity." Experimental cell research. 1999 Oct 10; 252(1):154-64.
1999 Sep 16
Steinburg MF, Schock D, Backus JW, Smith HC. "Tissue-specific differences in the role of RNA 3' of the apolipoprotein B mRNA mooring sequence in editosome assembly." Biochemical and biophysical research communications. 1999 Sep 16; 263(1):81-6.
1999 Aug 1
Sowden MP, Collins HL, Smith HC, Garrow TA, Sparks JD, Sparks CE. "Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase." The Biochemical journal. 1999 Aug 1; 341 ( Pt 3):639-45.
1998 Nov 18
Van Mater D, Sowden MP, Cianci J, Sparks JD, Sparks CE, Ballatori N, Smith HC. "Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells." Biochemical and biophysical research communications. 1998 Nov 18; 252(2):334-9.
1998 May
Smith HC. "Analysis of protein complexes assembled on apolipoprotein B mRNA for mooring sequence-dependent RNA editing." Methods : a companion to Methods in enzymology. 1998 May; 15(1):27-39.
1998 Apr 1
Sowden MP, Eagleton MJ, Smith HC. "Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing." Nucleic acids research. 1998 Apr 1; 26(7):1644-52.
1998 Feb 15
Stewart J, Kozlowski P, Sowden M, Messing E, Smith HC. "A quantitative assay for assessing allelic proportions by iterative gap ligation." Nucleic acids research. 1998 Feb 15; 26(4):961-6.
1997 Nov 25
Yang Y, Yang Y, Smith HC. "Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing." Proceedings of the National Academy of Sciences of the United States of America. 1997 Nov 25; 94(24):13075-80.
1997 Oct 31
Yang Y, Yang Y, Kovalski K, Smith HC. "Partial characterization of the auxiliary factors involved in apolipoprotein B mRNA editing through APOBEC-1 affinity chromatography." The Journal of biological chemistry. 1997 Oct 31; 272(44):27700-6.
1997 Oct
Smith HC, Gott JM, Hanson MR. "A guide to RNA editing." RNA. 1997 Oct; 3(10):1105-23.
1997 Jul 12
Sparks JD, Collins HL, Sabio I, Sowden MP, Smith HC, Cianci J, Sparks CE. "Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells." Biochimica et biophysica acta. 1997 Jul 12; 1347(1):51-61.
1996 Oct
Smith HC, Sowden MP. "Base-modification mRNA editing through deamination--the good, the bad and the unregulated." Trends in genetics : TIG. 1996 Oct; 12(10):418-24.
1996 Sep
Phung TL, Sowden MP, Sparks JD, Sparks CE, Smith HC. "Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat." Metabolism: clinical and experimental. 1996 Sep; 45(9):1056-8.
1996 Mar
Sowden M, Hamm JK, Spinelli S, Smith HC. "Determinants involved in regulating the proportion of edited apolipoprotein B RNAs." RNA. 1996 Mar; 2(3):274-88.
1996 Feb 9
Sowden M, Hamm JK, Smith HC. "Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing." The Journal of biological chemistry. 1996 Feb 9; 271(6):3011-7.
1996 Feb 6
Schock D, Kuo SR, Steinburg MF, Bolognino M, Sparks JD, Sparks CE, Smith HC. "An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing." Proceedings of the National Academy of Sciences of the United States of America. 1996 Feb 6; 93(3):1097-102.
1996 Feb 1
Skuse GR, Cappione AJ, Sowden M, Metheny LJ, Smith HC. "The neurofibromatosis type I messenger RNA undergoes base-modification RNA editing." Nucleic acids research. 1996 Feb 1; 24(3):478-85.
1996 Jan 26
Yang Y, Smith HC. "In vitro reconstitution of apolipoprotein B RNA editing activity from recombinant APOBEC-1 and McArdle cell extracts." Biochemical and biophysical research communications. 1996 Jan 26; 218(3):797-801.
1995 Mar
Davidson NO, Innerarity TL, Scott J, Smith H, Driscoll DM, Teng B, Chan L. "Proposed nomenclature for the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme: APOBEC-1." RNA. 1995 Mar; 1(1):3.
FOLPE, A.; LAPHAM, L.W.; SMITH, H.C.;. "Herpes simplex myelitis as a cause of the acute necrotizing myelitis syndrome". Neurology. 1995; 44(3): 1955-1957. Link
1994 Oct
Folpe A, Lapham LW, Smith HC. "Herpes simplex myelitis as a cause of acute necrotizing myelitis syndrome." Neurology. 1994 Oct; 44(10):1955-7.
1994 Sep 13
Backus JW, Schock D, Smith HC. "Only cytidines 5' of the apolipoprotein B mRNA mooring sequence are edited." Biochimica et biophysica acta. 1994 Sep 13; 1219(1):1-14.
1994 Jan 18
Backus JW, Smith HC. "Specific 3' sequences flanking a minimal apolipoprotein B (apoB) mRNA editing 'cassette' are critical for efficient editing in vitro." Biochimica et biophysica acta. 1994 Jan 18; 1217(1):65-73.
1993 Dec 30
Barnes C, Smith HC. "Apolipoprotein B mRNA editing in vitro is a zinc-dependent process." Biochemical and biophysical research communications. 1993 Dec 30; 197(3):1410-4.
1993 Aug
Smith HC. "Apolipoprotein B mRNA editing: the sequence to the event." Seminars in cell biology. 1993 Aug; 4(4):267-78.
1993 Apr 5
Harris SG, Sabio I, Mayer E, Steinberg MF, Backus JW, Sparks JD, Sparks CE, Smith HC. "Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins." The Journal of biological chemistry. 1993 Apr 5; 268(10):7382-92.
1993 Feb
Ludlow JW, Howell RL, Smith HC. "Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression." Oncogene. 1993 Feb; 8(2):331-9.
1992 Nov 25
Backus JW, Smith HC. "Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro." Nucleic acids research. 1992 Nov 25; 20(22):6007-14.
1992 May
Sparks JD, Zolfaghari R, Sparks CE, Smith HC, Fisher EA. "Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats." The Journal of clinical investigation. 1992 May; 89(5):1418-30.
1992 Mar 16
Harris SG, Smith HC. "In vitro apolipoprotein B mRNA editing activity can be modulated by fasting and refeeding rats with a high carbohydrate diet." Biochemical and biophysical research communications. 1992 Mar 16; 183(2):899-903.
Smith HC. "Organization of RNA splicing in the cell nucleus." Current topics in cellular regulation. 1992 33:145-66.
1991 Dec 25
Backus JW, Smith HC. "Apolipoprotein B mRNA sequences 3' of the editing site are necessary and sufficient for editing and editosome assembly." Nucleic acids research. 1991 Dec 25; 19(24):6781-6.
1991 Sep 25
Butler AJ, Eagleton MJ, Wang D, Howell RL, Strauch AR, Khasgiwala V, Smith HC. "Induction of the proliferative phenotype in differentiated myogenic cells by hypoxia." The Journal of biological chemistry. 1991 Sep 25; 266(27):18250-8.
1991 May 15
Roll DE, Murphy BJ, Laderoute KR, Sutherland RM, Smith HC. "Oxygen regulated 80 kDa protein and glucose regulated 78kDa protein are identical." Molecular and cellular biochemistry. 1991 May 15; 103(2):141-8.
1991 Feb 15
Smith HC, Kuo SR, Backus JW, Harris SG, Sparks CE, Sparks JD. "In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex." Proceedings of the National Academy of Sciences of the United States of America. 1991 Feb 15; 88(4):1489-93.
1990 Oct 15
Boix J, Habets WJ, van Venrooij WJ, Smith HC. "Analysis of U1snRNP-specific A protein cross-linked complexes." FEBS letters. 1990 Oct 15; 272(1-2):213-6.
1990 Jul 31
Backus JW, Eagleton MJ, Harris SG, Sparks CE, Sparks JD, Smith HC. "Quantitation of endogenous liver apolipoprotein B mRNA editing." Biochemical and biophysical research communications. 1990 Jul 31; 170(2):513-8.
1989 Jun
Smith HC, Harris SG, Zillmann M, Berget SM. "Evidence that a nuclear matrix protein participates in premessenger RNA splicing." Experimental cell research. 1989 Jun; 182(2):521-33.
1989 May 8
Liew CC, Smith HC. "Immunological evidence for the role of phosphoprotein p68/pI = 7.3 in premessenger RNA splicing." FEBS letters. 1989 May 8; 248(1-2):101-4.
1988 Nov
Harris SG, Martin TE, Smith HC. "Reversible chemical cross-linking and ribonuclease digestion analysis of the organization of proteins in ribonucleoprotein particles." Molecular and cellular biochemistry. 1988 Nov; 84(1):17-28.
1988 Jun 28
Harris SG, Hoch SO, Smith HC. "Chemical cross-linking of Sm and RNP antigenic proteins." Biochemistry. 1988 Jun 28; 27(13):4595-600.
1988 May 16
Harris SG, Smith HC. "SnRNP core protein enrichment in the nuclear matrix." Biochemical and biophysical research communications. 1988 May 16; 152(3):1383-7.
1987 Dec
Smith HC, Rothblum LI. "Ribosomal DNA sequences attached to the nuclear matrix." Biochemical genetics. 1987 Dec; 25(11-12):863-79.
1987 Sep
Smith HC, Ochs RL, Lin D, Chinault AC. "Ultrastructural and biochemical comparisons of nuclear matrices prepared by high salt or LIS extraction." Molecular and cellular biochemistry. 1987 Sep; 77(1):49-61.
1986 May
Smith HC, Ochs RL, Fernandez EA, Spector DL. "Macromolecular domains containing nuclear protein p107 and U-snRNP protein p28: further evidence for an in situ nuclear matrix." Molecular and cellular biochemistry. 1986 May; 70(2):151-68.
1986 Mar
Spector DL, Smith HC. "Redistribution of U-snRNPs during mitosis." Experimental cell research. 1986 Mar; 163(1):87-94.
SMITH, H.C.; SPECTOR, D.L.; WOODCOCK, C.L.F.; OCHS, R.L.; BHORJEE, J.;. "Alterations in chromatin Condensation sate are accompanied by reorganization of nonchromatin domains that contain U-snRNP proteins and nuclear protein p107". J. Cell Biol. 1986; 101(3): 560-567. Link
1985 Oct
Gupta RC, Dighe NR, Randerath K, Smith HC. "Distribution of initial and persistent 2-acetylaminofluorene-induced DNA adducts within DNA loops." Proceedings of the National Academy of Sciences of the United States of America. 1985 Oct; 82(19):6605-8.
1985 Jul 24
Tubo RA, Smith HC, Berezney R. "The nuclear matrix continues DNA synthesis at in vivo replicational forks." Biochimica et biophysica acta. 1985 Jul 24; 825(3):326-34.
1985 Feb 26
Smith HC, Berezney R, Brewster JM, Rekosh D. "Properties of adenoviral DNA bound to the nuclear matrix." Biochemistry. 1985 Feb 26; 24(5):1197-202.
1984 Nov
Smith HC, Puvion E, Buchholtz LA, Berezney R. "Spatial distribution of DNA loop attachment and replicational sites in the nuclear matrix." The Journal of cell biology. 1984 Nov; 99(5):1794-802.
1983 Jun 21
Smith HC, Berezney R. "Dynamic domains of DNA polymerase alpha in regenerating rat liver." Biochemistry. 1983 Jun 21; 22(13):3042-6.
1982 Dec 21
Smith HC, Berezney R. "Nuclear matrix-bound deoxyribonucleic acid synthesis: an in vitro system." Biochemistry. 1982 Dec 21; 21(26):6751-61.
1980 Dec 31
Smith HC, Berezney R. "DNA polymerase alpha is tightly bound to the nuclear matrix of actively replicating liver." Biochemical and biophysical research communications. 1980 Dec 31; 97(4):1541-7.


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Smtih, Harold, C.. "Determination of C to U Editing Activity in Cells and Biochemical Isolates". methods in Enzymology. Gott, J. : Academic Press, 2007.
Smith, Harold, C.. "Editing Informational Content of Expressed DNA Sequences and Their Transcripts". The Implicit Genome. Caporale, L.. : Oxford University Press, 2006. 248-265
Smith, H.C. Sowden, M.P. Xie, K. & Wedekend, J.E.. "Structure and Function of Mammalian Cytidine Deaminases that Mediate Expressed Sequence Diversification". Topics in Current Genetics. Grosjean, H.. : Springer-Verlag, 2005. 1610-2096
Smith, Harold C.. "RNA Editing". Encyclopedia of Life Sciences. : Macmillan Reference Ltd, Stockton Press, 2000.
Smith, Harold C.. "Macromolecular complexes involved in apolipoprotein B mRNA editing". Methods in Enzymology, RNA Editing. Chan, L.. : Academic Press, 1998. 27-39
Smith, H.C., Howell, R.L. & Ludlow, J.W.. "Alterations in cell cycle control factors and the induction of oxygen-regulated stress proteins by hypoxic stress". Cell Biology of Trauma. Lemasters, J.J. and Oliver, C.,. : CRC Press, Inc, 1994. 213-225
Smith, Harold, C.. "Organization of nuclear mRNA splicing domains". Current Topics in Cell Regulation. : Academic Press, 1992. 145-166
Smith, Harold C.. "Ribonucleoprotein organization: from cell nucleus to RNP". Structural Aspects of Metabolic. Regulation. Srere, P., Jones, M.E. and Mathews, C. : UCLA Symp. Molec. Cell. Biol, 1989. 43-56
Berezney, R., Basler, J., Buchholtz, L.A., Smith, H.C. & Siegel,. "Nuclear organization and DNA replication.". The Nuclear Envelope and Nuclear Matrix. Maul, G.G.. : A.R. Liss Pub. Co, 1982. 183-197