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Keith Nehrke, Ph.D.


Showing all 65 journal articles & 3 books available

Journal Articles

Nehrke K. "H(OH), H(OH), H(OH): a holiday perspective. Focus on "Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH- conductance pathway that is stimulated by rises in intracellular and extracellular pH"." American journal of physiology. Cell physiology.. 2016 Dec 1; 311(6):C942-C944. Epub 2016 Oct 26.

Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS. "Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling." The Journal of biological chemistry.. 2016 Sep 16; 291(38):20188-97. Epub 2016 Aug 10.

Wojtovich AP, Wei AY, Sherman TA, Foster TH, Nehrke K. "Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans." Scientific reports.. 2016 Jul 21; 6:29695. Epub 2016 Jul 21.

Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K. "Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning." Anesthesiology.. 2016 May 0; 124(5):1065-76.

Allman E, Wang Q, Walker RL, Austen M, Peters MA, Nehrke K. "Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans." American journal of physiology. Cell physiology.. 2016 Feb 1; 310(3):C233-42. Epub 2015 Nov 11.

Peña S, Sherman T, Brookes PS, Nehrke K. "The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans." PloS one. 2016 11(7):e0159989. Epub 2016 Jul 26.

Panitz D, Swamy H, Nehrke K. "A C. elegans model of electronic cigarette use: Physiological effects of e-liquids in nematodes." BMC pharmacology & toxicology. 2015 Dec 4; 16:32. Epub 2015 Dec 04.

Nehrke K. "Membrane ion transport in non-excitable tissues." WormBook : the online review of C. elegans biology.. 2014 Dec 23; :1-22. Epub 2014 Dec 23.

Queliconi BB, Kowaltowski AJ, Nehrke K. "An anoxia-starvation model for ischemia/reperfusion in C. elegans." Journal of visualized experiments : JoVE.. 2014 Mar 11; (85)Epub 2014 Mar 11.

Matthews TA, Abel A, Demme C, Sherman T, Pan PW, Halterman MW, Parkkila S, Nehrke K. "Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia." Brain research.. 2014 Jan 16; 1543:28-37. Epub 2013 Nov 23.

Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D. "Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans." PLoS biology.. 2013 Jul 0; 11(7):e1001613. Epub 2013 Jul 23.

Wojtovich AP, Urciuoli WR, Chatterjee S, Fisher AB, Nehrke K, Brookes PS. "Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning." American journal of physiology. Heart and circulatory physiology.. 2013 Jun 1; 304(11):H1439-45. Epub 2013 Apr 12.

Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS. "Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel." Biochimica et biophysica acta.. 2013 May 0; 1827(5):598-611. Epub 2013 Jan 02.

Allman E, Waters K, Ackroyd S, Nehrke K. "Analysis of Ca2+ signaling motifs that regulate proton signaling through the Na+/H+ exchanger NHX-7 during a rhythmic behavior in Caenorhabditis elegans." The Journal of biological chemistry.. 2013 Feb 22; 288(8):5886-95. Epub 2013 Jan 14.

Portal-Celhay C, Nehrke K, Blaser MJ. "Effect of Caenorhabditis elegans age and genotype on horizontal gene transfer in intestinal bacteria." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2013 Feb 0; 27(2):760-8. Epub 2012 Oct 19.

Queliconi BB, Marazzi TB, Vaz SM, Brookes PS, Nehrke K, Augusto O, Kowaltowski AJ. "Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion." Free radical biology & medicine.. 2013 Feb 0; 55:46-53. Epub 2012 Nov 27.

Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS. "A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel." PeerJ. 2013 1:e48. Epub 2013 Mar 05.

Kemp BJ, Allman E, Immerman L, Mohnen M, Peters MA, Nehrke K, Abbott AL. "miR-786 regulation of a fatty-acid elongase contributes to rhythmic calcium-wave initiation in C. elegans." Current biology : CB.. 2012 Dec 4; 22(23):2213-20. Epub 2012 Nov 06.

Perry GM, Nehrke KW, Bushinsky DA, Reid R, Lewandowski KL, Hueber P, Scheinman SJ. "Sex modifies genetic effects on residual variance in urinary calcium excretion in rat (Rattus norvegicus)." Genetics.. 2012 Jul 0; 191(3):1003-13. Epub 2012 May 02.

Johnson D, Allman E, Nehrke K. "Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation." American journal of physiology. Cell physiology.. 2012 Apr 1; 302(7):C1045-54. Epub 2012 Jan 11.

Sherman TA, Rongali S, Matthews TA, Pfeiffer J, Nehrke K. "Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans." Biochimica et biophysica acta.. 2012 Apr 0; 1823(4):808-17. Epub 2012 Jan 05.

Wojtovich AP, Distefano P, Sherman T, Brookes PS, Nehrke K. "Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans." FEBS letters.. 2012 Feb 17; 586(4):428-34. Epub 2012 Jan 21.

Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K. "Ischemic preconditioning: the role of mitochondria and aging." Experimental gerontology.. 2012 Jan 0; 47(1):1-7. Epub 2011 Nov 10.

Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K. "SLO-2 is cytoprotective and contributes to mitochondrial potassium transport." PloS one. 2011 6(12):e28287. Epub 2011 Dec 01.

Johnson D, Nehrke K. "Mitochondrial fragmentation leads to intracellular acidification in Caenorhabditis elegans and mammalian cells." Molecular biology of the cell.. 2010 Jul 1; 21(13):2191-201. Epub 2010 May 05.

Wojtovich AP, Williams DM, Karcz MK, Lopes CM, Gray DA, Nehrke KW, Brookes PS. "A novel mitochondrial K(ATP) channel assay." Circulation research.. 2010 Apr 16; 106(7):1190-6. Epub 2010 Feb 25.

Wojtovich AP, Nehrke KW, Brookes PS. "The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria." Acta biochimica Polonica. 2010 57(4):431-4. Epub 2010 Nov 19.

Allman E, Johnson D, Nehrke K. "Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans." American journal of physiology. Cell physiology.. 2009 Nov 0; 297(5):C1071-81. Epub 2009 Sep 09.

Frick KK, Krieger NS, Nehrke K, Bushinsky DA. "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Feb 0; 24(2):305-13.

Wojtovich AP, Burwell LS, Sherman TA, Nehrke KW, Brookes PS. "The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning." Biochemical and biophysical research communications.. 2008 Nov 21; 376(3):625-8. Epub 2008 Sep 20.

Pfeiffer J, Johnson D, Nehrke K. "Oscillatory transepithelial H(+) flux regulates a rhythmic behavior in C. elegans." Current biology : CB.. 2008 Feb 26; 18(4):297-302.

Nehrke K, Denton J, Mowrey W. "Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program." American journal of physiology. Cell physiology.. 2008 Jan 0; 294(1):C333-44. Epub 2007 Oct 17.

Yan X, Xing J, Lorin-Nebel C, Estevez AY, Nehrke K, Lamitina T, Strange K. "Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis." The Journal of general physiology.. 2006 Oct 0; 128(4):443-59. Epub 2006 Sep 11.

He L, Denton J, Nehrke K, Strange K. "Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity." Biophysical journal.. 2006 May 15; 90(10):3570-81. Epub 2006 Feb 24.

Denton J, Nehrke K, Yin X, Beld AM, Strange K. "Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte." American journal of physiology. Cell physiology.. 2006 Apr 0; 290(4):C1109-18. Epub 2005 Nov 23.

de Santiago JA, Nehrke K, Arreola J. "Quantitative analysis of the voltage-dependent gating of mouse parotid ClC-2 chloride channel." The Journal of general physiology.. 2005 Dec 0; 126(6):591-603. Epub 2005 Nov 14.

Sherman T, Chernova MN, Clark JS, Jiang L, Alper SL, Nehrke K. "The abts and sulp families of anion transporters from Caenorhabditis elegans." American journal of physiology. Cell physiology.. 2005 Aug 0; 289(2):C341-51. Epub 2005 Apr 06.

Denton J, Nehrke K, Yin X, Morrison R, Strange K. "GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel." The Journal of general physiology.. 2005 Feb 0; 125(2):113-25.

Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE. "Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4." The Journal of biological chemistry.. 2004 Nov 12; 279(46):47681-7. Epub 2004 Sep 03.

Denton J, Nehrke K, Rutledge E, Morrison R, Strange K. "Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+." The Journal of physiology.. 2004 Feb 15; 555(Pt 1):97-114. Epub 2003 Oct 17.

Chen Y, Zhao YH, Kalaslavadi TB, Hamati E, Nehrke K, Le AD, Ann DK, Wu R. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues." American journal of respiratory cell and molecular biology.. 2004 Feb 0; 30(2):155-65. Epub 2003 Jul 25.

Nehrke K. "A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span." The Journal of biological chemistry.. 2003 Nov 7; 278(45):44657-66. Epub 2003 Aug 25.

Joiner WJ, Basavappa S, Vidyasagar S, Nehrke K, Krishnan S, Binder HJ, Boulpaep EL, Rajendran VM. "Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon." American journal of physiology. Gastrointestinal and liver physiology.. 2003 Jul 0; 285(1):G185-96. Epub 2003 Feb 26.

Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. "The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells." Proceedings of the National Academy of Sciences of the United States of America.. 2003 Jun 10; 100(12):7366-71. Epub 2003 May 28.

Nehrke K, Quinn CC, Begenisich T. "Molecular identification of Ca2+-activated K+ channels in parotid acinar cells." American journal of physiology. Cell physiology.. 2003 Feb 0; 284(2):C535-46. Epub 2002 Oct 16.

Dickerson LW, Bonthius DJ, Schutte BC, Yang B, Barna TJ, Bailey MC, Nehrke K, Williamson RA, Lamb FS. "Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels." Brain research.. 2002 Dec 27; 958(2):227-50.

Arreola J, Begenisich T, Nehrke K, Nguyen HV, Park K, Richardson L, Yang B, Schutte BC, Lamb FS, Melvin JE. "Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene." The Journal of physiology.. 2002 Nov 15; 545(Pt 1):207-16.

Nehrke K, Melvin JE. "The NHX family of Na+-H+ exchangers in Caenorhabditis elegans." The Journal of biological chemistry.. 2002 Aug 9; 277(32):29036-44. Epub 2002 May 20.

Nehrke K, Arreola J, Nguyen HV, Pilato J, Richardson L, Okunade G, Baggs R, Shull GE, Melvin JE. "Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice." The Journal of biological chemistry.. 2002 Jun 28; 277(26):23604-11. Epub 2002 Apr 25.

Elble RC, Ji G, Nehrke K, DeBiasio J, Kingsley PD, Kotlikoff MI, Pauli BU. "Molecular and functional characterization of a murine calcium-activated chloride channel expressed in smooth muscle." The Journal of biological chemistry.. 2002 May 24; 277(21):18586-91. Epub 2002 Mar 14.

Attaphitaya S, Nehrke K, Melvin JE. "Acute inhibition of brain-specific Na(+)/H(+) exchanger isoform 5 by protein kinases A and C and cell shrinkage." American journal of physiology. Cell physiology.. 2001 Oct 0; 281(4):C1146-57.

Yan W, Nehrke K, Choi J, Barber DL. "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor." The Journal of biological chemistry.. 2001 Aug 17; 276(33):31349-56. Epub 2001 May 21.

Park K, Evans RL, Watson GE, Nehrke K, Richardson L, Bell SM, Schultheis PJ, Hand AR, Shull GE, Melvin JE. "Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient mice." The Journal of biological chemistry.. 2001 Jul 20; 276(29):27042-50. Epub 2001 May 17.

Melvin JE, Nguyen HV, Nehrke K, Schreiner CM, Ten Hagen KG, Scott W. "Targeted disruption of the Nhe1 gene fails to inhibit beta(1)-adrenergic receptor-induced parotid gland hypertrophy." American journal of physiology. Gastrointestinal and liver physiology.. 2001 Apr 0; 280(4):G694-700.

Nehrke K, Begenisich T, Pilato J, Melvin JE. "Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression." American journal of physiology. Cell physiology.. 2000 Dec 0; 279(6):C2052-66.

Hagen FK, Nehrke K. "cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans." The Journal of biological chemistry.. 1998 Apr 3; 273(14):8268-77.

Nehrke K, Hagen FK, Tabak LA. "Isoform-specific O-glycosylation by murine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, in vivo." Glycobiology.. 1998 Apr 0; 8(4):367-71.

Nehrke K, Ten Hagen KG, Hagen FK, Tabak LA. "Charge distribution of flanking amino acids inhibits O-glycosylation of several single-site acceptors in vivo." Glycobiology.. 1997 Dec 0; 7(8):1053-60.

Nehrke K, Tabak LA. "Biosynthesis of a low-molecular-mass rat submandibular gland mucin glycoprotein in COS7 cells." The Biochemical journal.. 1997 Apr 15; 323 ( Pt 2):497-502.

Nehrke K, Hagen FK, Tabak LA. "Charge distribution of flanking amino acids influences O-glycan acquisition in vivo." The Journal of biological chemistry.. 1996 Mar 22; 271(12):7061-5.

Russnak R, Nehrke KW, Platt T. "REF2 encodes an RNA-binding protein directly involved in yeast mRNA 3'-end formation." Molecular and cellular biology.. 1995 Mar 0; 15(3):1689-97.

Nehrke KW, Platt T. "A quaternary transcription termination complex. Reciprocal stabilization by Rho factor and NusG protein." Journal of molecular biology.. 1994 Nov 11; 243(5):830-9.

Nehrke KW, Zalatan F, Platt T. "NusG alters rho-dependent termination of transcription in vitro independent of kinetic coupling." Gene expression. 1993 3(2):119-33.

Nehrke KW, Seifried SE, Platt T. "Overproduced rho factor from p39AS has lysine replacing glutamic acid at residue 155 in the linker region between its RNA and ATP binding domains." Nucleic acids research.. 1992 Nov 25; 20(22):6107.

Phizicky EM, Consaul SA, Nehrke KW, Abelson J. "Yeast tRNA ligase mutants are nonviable and accumulate tRNA splicing intermediates." The Journal of biological chemistry.. 1992 Mar 5; 267(7):4577-82.

Books & Chapters

Book Title: Intracellular pH measurements in vivo using green fluorescent protein variants.
Author List: Nehrke K.
Edited By: K. Strange
Published By: Methods Mol Biol.2006

Chapter Title: Ca2+-Activated Cl- Currents in Salivary and Lacrimal Glands.
Book Title: Current Topics in Membranes
Author List: Melvin J.E., Arreola J., Nehrke K., and Begenisich, T.
Edited By: C.;M. Fuller
Published By: Academic Press2002 in San Diego

Chapter Title: Experimental Approaches to Studying O-Glycosylation In Vivo.
Book Title: Techniques in Glycobiology
Author List: Nehrke K., Hagen F.H., and Tabak, L.A.
Edited By: R. Townsend and A. Hotchkiss
Published By: Marcel Dekker1997 in New York