Keith Nehrke, Ph.D.

Keith Nehrke, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 675
Rochester, NY 14642

Office: (585) 275-7020
Administrative: (585) 275-1554
Fax: (585) 442-9201
Lab: (585) 275-1625

Journal Articles

Showing all 65 journal articles available.

2016 Dec 1
Nehrke K. "H(OH), H(OH), H(OH): a holiday perspective. Focus on "Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH- conductance pathway that is stimulated by rises in intracellular and extracellular pH"." American journal of physiology. Cell physiology. 2016 Dec 1; 311(6):C942-C944. Epub 2016 Oct 26.
2016 Sep 16
Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS. "Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling." The Journal of biological chemistry. 2016 Sep 16; 291(38):20188-97. Epub 2016 Aug 10.
2016 Jul 21
Wojtovich AP, Wei AY, Sherman TA, Foster TH, Nehrke K. "Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans." Scientific reports. 2016 Jul 21; 6:29695. Epub 2016 Jul 21.
2016 May
Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K. "Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning." Anesthesiology. 2016 May; 124(5):1065-76.
2016 Feb 1
Allman E, Wang Q, Walker RL, Austen M, Peters MA, Nehrke K. "Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans." American journal of physiology. Cell physiology. 2016 Feb 1; 310(3):C233-42. Epub 2015 Nov 11.
Peña S, Sherman T, Brookes PS, Nehrke K. "The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans." PloS one. 2016 11(7):e0159989. Epub 2016 Jul 26.
2015 Dec 4
Panitz D, Swamy H, Nehrke K. "A C. elegans model of electronic cigarette use: Physiological effects of e-liquids in nematodes." BMC pharmacology & toxicology. 2015 Dec 4; 16:32. Epub 2015 Dec 04.
2014 Dec 23
Nehrke K. "Membrane ion transport in non-excitable tissues." WormBook : the online review of C. elegans biology. 2014 Dec 23; :1-22. Epub 2014 Dec 23.
2014 Mar 11
Queliconi BB, Kowaltowski AJ, Nehrke K. "An anoxia-starvation model for ischemia/reperfusion in C. elegans." Journal of visualized experiments : JoVE. 2014 Mar 11; (85)Epub 2014 Mar 11.
2014 Jan 16
Matthews TA, Abel A, Demme C, Sherman T, Pan PW, Halterman MW, Parkkila S, Nehrke K. "Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia." Brain research. 2014 Jan 16; 1543:28-37. Epub 2013 Nov 23.
2013 Jul
Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D. "Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans." PLoS biology. 2013 Jul; 11(7):e1001613. Epub 2013 Jul 23.
2013 Jun 1
Wojtovich AP, Urciuoli WR, Chatterjee S, Fisher AB, Nehrke K, Brookes PS. "Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning." American journal of physiology. Heart and circulatory physiology. 2013 Jun 1; 304(11):H1439-45. Epub 2013 Apr 12.
2013 May
Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS. "Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel." Biochimica et biophysica acta. 2013 May; 1827(5):598-611. Epub 2013 Jan 02.
2013 Feb 22
Allman E, Waters K, Ackroyd S, Nehrke K. "Analysis of Ca2+ signaling motifs that regulate proton signaling through the Na+/H+ exchanger NHX-7 during a rhythmic behavior in Caenorhabditis elegans." The Journal of biological chemistry. 2013 Feb 22; 288(8):5886-95. Epub 2013 Jan 14.
2013 Feb
Portal-Celhay C, Nehrke K, Blaser MJ. "Effect of Caenorhabditis elegans age and genotype on horizontal gene transfer in intestinal bacteria." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 Feb; 27(2):760-8. Epub 2012 Oct 19.
2013 Feb
Queliconi BB, Marazzi TB, Vaz SM, Brookes PS, Nehrke K, Augusto O, Kowaltowski AJ. "Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion." Free radical biology & medicine. 2013 Feb; 55:46-53. Epub 2012 Nov 27.
Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS. "A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel." PeerJ. 2013 1:e48. Epub 2013 Mar 05.
2012 Dec 4
Kemp BJ, Allman E, Immerman L, Mohnen M, Peters MA, Nehrke K, Abbott AL. "miR-786 regulation of a fatty-acid elongase contributes to rhythmic calcium-wave initiation in C. elegans." Current biology : CB. 2012 Dec 4; 22(23):2213-20. Epub 2012 Nov 06.
2012 Jul
Perry GM, Nehrke KW, Bushinsky DA, Reid R, Lewandowski KL, Hueber P, Scheinman SJ. "Sex modifies genetic effects on residual variance in urinary calcium excretion in rat (Rattus norvegicus)." Genetics. 2012 Jul; 191(3):1003-13. Epub 2012 May 02.
2012 Apr 1
Johnson D, Allman E, Nehrke K. "Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation." American journal of physiology. Cell physiology. 2012 Apr 1; 302(7):C1045-54. Epub 2012 Jan 11.
2012 Apr
Sherman TA, Rongali S, Matthews TA, Pfeiffer J, Nehrke K. "Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans." Biochimica et biophysica acta. 2012 Apr; 1823(4):808-17. Epub 2012 Jan 05.
2012 Feb 17
Wojtovich AP, Distefano P, Sherman T, Brookes PS, Nehrke K. "Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans." FEBS letters. 2012 Feb 17; 586(4):428-34. Epub 2012 Jan 21.
2012 Jan
Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K. "Ischemic preconditioning: the role of mitochondria and aging." Experimental gerontology. 2012 Jan; 47(1):1-7. Epub 2011 Nov 10.
Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K. "SLO-2 is cytoprotective and contributes to mitochondrial potassium transport." PloS one. 2011 6(12):e28287. Epub 2011 Dec 01.
2010 Jul 1
Johnson D, Nehrke K. "Mitochondrial fragmentation leads to intracellular acidification in Caenorhabditis elegans and mammalian cells." Molecular biology of the cell. 2010 Jul 1; 21(13):2191-201. Epub 2010 May 05.
2010 Apr 16
Wojtovich AP, Williams DM, Karcz MK, Lopes CM, Gray DA, Nehrke KW, Brookes PS. "A novel mitochondrial K(ATP) channel assay." Circulation research. 2010 Apr 16; 106(7):1190-6. Epub 2010 Feb 25.
Wojtovich AP, Nehrke KW, Brookes PS. "The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria." Acta biochimica Polonica. 2010 57(4):431-4. Epub 2010 Nov 19.
2009 Nov
Allman E, Johnson D, Nehrke K. "Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans." American journal of physiology. Cell physiology. 2009 Nov; 297(5):C1071-81. Epub 2009 Sep 09.
2009 Feb
Frick KK, Krieger NS, Nehrke K, Bushinsky DA. "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2009 Feb; 24(2):305-13.
2008 Nov 21
Wojtovich AP, Burwell LS, Sherman TA, Nehrke KW, Brookes PS. "The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning." Biochemical and biophysical research communications. 2008 Nov 21; 376(3):625-8. Epub 2008 Sep 20.
2008 Feb 26
Pfeiffer J, Johnson D, Nehrke K. "Oscillatory transepithelial H(+) flux regulates a rhythmic behavior in C. elegans." Current biology : CB. 2008 Feb 26; 18(4):297-302.
2008 Jan
Nehrke K, Denton J, Mowrey W. "Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program." American journal of physiology. Cell physiology. 2008 Jan; 294(1):C333-44. Epub 2007 Oct 17.
2006 Oct
Yan X, Xing J, Lorin-Nebel C, Estevez AY, Nehrke K, Lamitina T, Strange K. "Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis." The Journal of general physiology. 2006 Oct; 128(4):443-59. Epub 2006 Sep 11.
2006 May 15
He L, Denton J, Nehrke K, Strange K. "Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity." Biophysical journal. 2006 May 15; 90(10):3570-81. Epub 2006 Feb 24.
2006 Apr
Denton J, Nehrke K, Yin X, Beld AM, Strange K. "Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte." American journal of physiology. Cell physiology. 2006 Apr; 290(4):C1109-18. Epub 2005 Nov 23.
2005 Dec
de Santiago JA, Nehrke K, Arreola J. "Quantitative analysis of the voltage-dependent gating of mouse parotid ClC-2 chloride channel." The Journal of general physiology. 2005 Dec; 126(6):591-603. Epub 2005 Nov 14.
2005 Aug
Sherman T, Chernova MN, Clark JS, Jiang L, Alper SL, Nehrke K. "The abts and sulp families of anion transporters from Caenorhabditis elegans." American journal of physiology. Cell physiology. 2005 Aug; 289(2):C341-51. Epub 2005 Apr 06.
2005 Feb
Denton J, Nehrke K, Yin X, Morrison R, Strange K. "GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel." The Journal of general physiology. 2005 Feb; 125(2):113-25.
2004 Nov 12
Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE. "Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4." The Journal of biological chemistry. 2004 Nov 12; 279(46):47681-7. Epub 2004 Sep 03.
2004 Feb 15
Denton J, Nehrke K, Rutledge E, Morrison R, Strange K. "Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+." The Journal of physiology. 2004 Feb 15; 555(Pt 1):97-114. Epub 2003 Oct 17.
2004 Feb
Chen Y, Zhao YH, Kalaslavadi TB, Hamati E, Nehrke K, Le AD, Ann DK, Wu R. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues." American journal of respiratory cell and molecular biology. 2004 Feb; 30(2):155-65. Epub 2003 Jul 25.
2003 Nov 7
Nehrke K. "A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span." The Journal of biological chemistry. 2003 Nov 7; 278(45):44657-66. Epub 2003 Aug 25.
2003 Jul
Joiner WJ, Basavappa S, Vidyasagar S, Nehrke K, Krishnan S, Binder HJ, Boulpaep EL, Rajendran VM. "Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon." American journal of physiology. Gastrointestinal and liver physiology. 2003 Jul; 285(1):G185-96. Epub 2003 Feb 26.
2003 Jun 10
Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. "The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells." Proceedings of the National Academy of Sciences of the United States of America. 2003 Jun 10; 100(12):7366-71. Epub 2003 May 28.
2003 Feb
Nehrke K, Quinn CC, Begenisich T. "Molecular identification of Ca2+-activated K+ channels in parotid acinar cells." American journal of physiology. Cell physiology. 2003 Feb; 284(2):C535-46. Epub 2002 Oct 16.
2002 Dec 27
Dickerson LW, Bonthius DJ, Schutte BC, Yang B, Barna TJ, Bailey MC, Nehrke K, Williamson RA, Lamb FS. "Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels." Brain research. 2002 Dec 27; 958(2):227-50.
2002 Nov 15
Arreola J, Begenisich T, Nehrke K, Nguyen HV, Park K, Richardson L, Yang B, Schutte BC, Lamb FS, Melvin JE. "Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene." The Journal of physiology. 2002 Nov 15; 545(Pt 1):207-16.
2002 Aug 9
Nehrke K, Melvin JE. "The NHX family of Na+-H+ exchangers in Caenorhabditis elegans." The Journal of biological chemistry. 2002 Aug 9; 277(32):29036-44. Epub 2002 May 20.
2002 Jun 28
Nehrke K, Arreola J, Nguyen HV, Pilato J, Richardson L, Okunade G, Baggs R, Shull GE, Melvin JE. "Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice." The Journal of biological chemistry. 2002 Jun 28; 277(26):23604-11. Epub 2002 Apr 25.
2002 May 24
Elble RC, Ji G, Nehrke K, DeBiasio J, Kingsley PD, Kotlikoff MI, Pauli BU. "Molecular and functional characterization of a murine calcium-activated chloride channel expressed in smooth muscle." The Journal of biological chemistry. 2002 May 24; 277(21):18586-91. Epub 2002 Mar 14.
2001 Oct
Attaphitaya S, Nehrke K, Melvin JE. "Acute inhibition of brain-specific Na(+)/H(+) exchanger isoform 5 by protein kinases A and C and cell shrinkage." American journal of physiology. Cell physiology. 2001 Oct; 281(4):C1146-57.
2001 Aug 17
Yan W, Nehrke K, Choi J, Barber DL. "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor." The Journal of biological chemistry. 2001 Aug 17; 276(33):31349-56. Epub 2001 May 21.
2001 Jul 20
Park K, Evans RL, Watson GE, Nehrke K, Richardson L, Bell SM, Schultheis PJ, Hand AR, Shull GE, Melvin JE. "Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient mice." The Journal of biological chemistry. 2001 Jul 20; 276(29):27042-50. Epub 2001 May 17.
2001 Apr
Melvin JE, Nguyen HV, Nehrke K, Schreiner CM, Ten Hagen KG, Scott W. "Targeted disruption of the Nhe1 gene fails to inhibit beta(1)-adrenergic receptor-induced parotid gland hypertrophy." American journal of physiology. Gastrointestinal and liver physiology. 2001 Apr; 280(4):G694-700.
2000 Dec
Nehrke K, Begenisich T, Pilato J, Melvin JE. "Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression." American journal of physiology. Cell physiology. 2000 Dec; 279(6):C2052-66.
1998 Apr 3
Hagen FK, Nehrke K. "cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans." The Journal of biological chemistry. 1998 Apr 3; 273(14):8268-77.
1998 Apr
Nehrke K, Hagen FK, Tabak LA. "Isoform-specific O-glycosylation by murine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, in vivo." Glycobiology. 1998 Apr; 8(4):367-71.
1997 Dec
Nehrke K, Ten Hagen KG, Hagen FK, Tabak LA. "Charge distribution of flanking amino acids inhibits O-glycosylation of several single-site acceptors in vivo." Glycobiology. 1997 Dec; 7(8):1053-60.
1997 Apr 15
Nehrke K, Tabak LA. "Biosynthesis of a low-molecular-mass rat submandibular gland mucin glycoprotein in COS7 cells." The Biochemical journal. 1997 Apr 15; 323 ( Pt 2):497-502.
1996 Mar 22
Nehrke K, Hagen FK, Tabak LA. "Charge distribution of flanking amino acids influences O-glycan acquisition in vivo." The Journal of biological chemistry. 1996 Mar 22; 271(12):7061-5.
1995 Mar
Russnak R, Nehrke KW, Platt T. "REF2 encodes an RNA-binding protein directly involved in yeast mRNA 3'-end formation." Molecular and cellular biology. 1995 Mar; 15(3):1689-97.
1994 Nov 11
Nehrke KW, Platt T. "A quaternary transcription termination complex. Reciprocal stabilization by Rho factor and NusG protein." Journal of molecular biology. 1994 Nov 11; 243(5):830-9.
Nehrke KW, Zalatan F, Platt T. "NusG alters rho-dependent termination of transcription in vitro independent of kinetic coupling." Gene expression. 1993 3(2):119-33.
1992 Nov 25
Nehrke KW, Seifried SE, Platt T. "Overproduced rho factor from p39AS has lysine replacing glutamic acid at residue 155 in the linker region between its RNA and ATP binding domains." Nucleic acids research. 1992 Nov 25; 20(22):6107.
1992 Mar 5
Phizicky EM, Consaul SA, Nehrke KW, Abelson J. "Yeast tRNA ligase mutants are nonviable and accumulate tRNA splicing intermediates." The Journal of biological chemistry. 1992 Mar 5; 267(7):4577-82.


Nehrke K.. Intracellular pH measurements in vivo using green fluorescent protein variants.. K. Strange. : Methods Mol Biol., 2006. 223-39
Melvin J.E., Arreola J., Nehrke K., and Begenisich, T.. "Ca2+-Activated Cl- Currents in Salivary and Lacrimal Glands.". Current Topics in Membranes. C.;M. Fuller. San Diego: Academic Press, 2002.
Nehrke K., Hagen F.H., and Tabak, L.A.. "Experimental Approaches to Studying O-Glycosylation In Vivo.". Techniques in Glycobiology. R. Townsend and A. Hotchkiss. New York: Marcel Dekker, 1997.