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Regis J. O'Keefe, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 275-5321

Administrative: (585) 275-3100

Administrative: (585) 273-1261

Office: (585) 275-5167

Fax: (585) 756-4721

Research Labs

The Center for Musculoskeletal Research houses nearly 70 MD and PhD researchers and graduate and post-doctoral students. This team has been the top orthopaedics lab in the United States since 2006.

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Biography

Dr. O'Keefe is an orthopaedic oncologist, or a surgeon who focuses his practice on people with tumors of bone, joints, and soft tissue. He also cares for patients with fragility fractures from osteoporosis, osteopenia, osteogenesis imperfecta, and low vitamin D. Because many patients entering Dr. O'Keefe's practice are experiencing the most challenging time of their life, his treatment goal is to provide the best quality of life possible and instill confidence in his patients that they are getting the best care possible.

Dr. O'Keefe earned his medical degree from Harvard Medical School and completed a residency in orthopaedic surgery at URMC. He then completed the Massachusetts General Hospital fellowship in orthopaedic oncology. Soon, he realized he could help more people if the causes of diseases of the skeleton were better understood. He earned a PhD in biochemistry at URMC while conducting research.

Dr. O'Keefe, a national leader in the field of orthopaedics, is the Chair of URMC's Department of Orthopaedics and Rehabilitation. He also serves as the Director of the Center for Musculoskeletal Research at URMC, a team of nearly 70 physicians, biomedical scientists, and graduate and post-doctoral students. This team remains the top orthopaedics research lab in the United States since 2006.

Credentials

Faculty Appointments

Specialties

  • Orthopaedic Surgery - American Board of Orthopedic Surgery

Education

1981
BA | Yale University
Philosophy

1985
MD | Harvard Medical School
Medicine

2000
PhD | University of Rochester School of Medicine and Dentistry
Biochemistry

Post-doctoral Training & Residency

07/01/1988 - 06/01/1992
Residency in Orthopaedic Surgery at University of Rochester Medical Center

07/01/1992 - 06/01/1993
Fellowship in at Massachusetts General Hospital

09/01/1985 - 06/30/1986
Internship in at Deaconess Hospital

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Awards

2009
Best Doctors in America for Cancerous Tumor Surgery

2003
Fifth Annual Dr. Marvin J Hoffman Award in the Area of Faculty Mentoring to Medical Students, Awarded at the Annual Hoffman Awards Ceremony,

2000
Dean's Endowed Chair, Professor of Orthopaedics and Oncology, University of Rochester School of Medicine.

1999
American Orthopaedic Association ABC Traveling Fellowship,

1998
Dean's Endowed Chair, Associate Professor of Orthopaedics, University of Rochester School of Medicine.

1997
The Dane and Mary Louise Miller Endowed Research Grant, Orthopaedic Research and Educational Foundation,

1995
Kappa Delta Award, Orthopaedic Research & Education Foundation.

1988
AOA Resident Traveling Research Award, "Differential expression of transforming growth factor-ß receptors and biological effects in maturationally distinct subpopulations of growth plate chondrocytes.

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Patents

Title: Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues
U.S. Serial #: 13/971,366
Filed: Aug 20, 2013
Invented By: HaniAwad, SusanBukata, RegisO'Keefe, J. EdwardPuzas, RandyRosier, ErikSampson, MichaelZuscik

Title: Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues
U.S. Serial #: 13/124,002
Filed: Oct 13, 2009
Invented By: HaniAwad, SusanBukata, RegisO'Keefe, J. EdwardPuzas, RandyRosier, ErikSampson, MichaelZuscik

Publications

Journal Articles

2014
Shane E, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster DW, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Howe TS, van der Meulen MC, Weinstein RS, Whyte MP. "Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American society for bone and mineral research." Journal of Bone and Mineral Research. 2014; .

2013
Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. "PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis." Journal of Bone and Mineral Research. 2013; 28(3): 586-97.

2013
Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ. "RBP-J?-Dependent Notch Signaling Is Required for Murine Articular Cartilage and Joint Maintenance." Arthritis Rheumatology. 2013; 65(10): 2623-33.

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Videos

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(CC) Dr. Regis O'Keefe & the CTSI Mentoring Program (Don't click CC button; captions embedded)

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(CC) Dr. Regis O'Keefe & the CTSI Mentoring Program (Don't click CC button; captions embedded)