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Charles A. Thornton, M.D.

Neurology

Clinical Interests

Neuromuscular Disease

Contact Information

Phone Numbers

Appointment: (585) 275-2559

Administrative: (585) 275-2542

Office: (585) 275-2542

Fax: (585) 276-1947

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groupAn Accountable Health Partner

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Research Labs

Lab: (585) 275-7108

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Faculty Appointments

Biography

Professional Background

Neurogenetic disorders, including myotonic dystrophy; therapeutics, including antisense approaches. Myotonia is a state of hyperexcitability in muscle fibers in which a voluntary contraction or electromechanical stimulation can provoke trains of repetitive action potentials. This causes delay in relaxation after a muscle contraction. The repetitive action potentials are generated by the muscle fibers, independent of any input from the motor neuron. Myotonia is caused by dysfunction of ion channels in the muscle membrane.

Myotonic dystrophy is the most common disease that causes myotonia. Recent studies in our laboratory indicate that the myotonia in myotonic dystrophy is caused, at least in part, by reduced expression of the ClC-1 chloride channel (Mankodi, et al, Molecular Cell, July 2002).

Several strains of mice with myotonia have been isolated. All spontaneous mutations that cause myotonia in mice are allelic. These strains are called "adr", for arrested development of righting response (i.e., the mice are slow to regain their upright posture after being tipped on their side). Adr strains have mutations in the murine Clcn1 gene, similar to the mutations that cause human generalized myotonia congenita.

Research

Neurogenetic disorders, including myotonic dystrophy; therapeutics, including antisense approaches. Myotonia is a state of hyperexcitability in muscle fibers in which a voluntary contraction or electromechanical stimulation can provoke trains of repetitive action potentials. This causes delay in relaxation after a muscle contraction. The repetitive action potentials are generated by the muscle fibers, independent of any input from the motor neuron. Myotonia is caused by dysfunction of ion channels in the muscle membrane.

Myotonic dystrophy is the most common disease that causes myotonia. Recent studies in our laboratory indicate that the myotonia in myotonic dystrophy is caused, at least in part, by reduced expression of the ClC-1 chloride channel (Mankodi, et al, Molecular Cell, July 2002).

Several strains of mice with myotonia have been isolated. All spontaneous mutations that cause myotonia in mice are allelic. These strains are called "adr", for arrested development of righting response (i.e., the mice are slow to regain their upright posture after being tipped on their side). Adr strains have mutations in the murine Clcn1 gene, similar to the mutations that cause human generalized myotonia congenita.

Credentials

Specialties

  • Neurology - American Board of Psychiatry and Neurology

Education

1977
BS | University of Iowa
Arts & Sciences

1981
MD | University Iowa Coll Medicine
Medicine

Post-doctoral Training & Residency

09/01/1990 - 06/30/1992
Fellowship in Experimental Therapeutics at University of Rochester School of Medicine & Dentistry

09/01/1989 - 06/30/1990
Fellowship in Neuromuscular Disease at University of Rochester School of Medicine & Dentistry

09/01/1982 - 06/30/1985
Residency in Neurology at Oregon Health Sciences University School of Med

09/01/1981 - 06/30/1982
Internship in Internal Medicine at UCLA School of Medicine

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Awards

2013
Carrell-Krusen Award
Sponsor: University of Texas Southwestern, Dallas, TX

2011
Hans Steinert Award for Myotonic Dystrophy Research

2010
Norman Saunders Jacob's Ladder International Research Prize

1997 - 2000
Paul B Beeson Physician Faculty Scholar Award
Sponsor: American Federation of Aging Research

1992 - 1997
Awardee, Clinical Investigator Development
Sponsor: NIH/NINDS

1991 - 1992
Awardee, Experimental Therapeutics Fellowship
Sponsor: NRSA

1989 - 1991
Awardee, Research Fellowship
Sponsor: Muscular Dystrophy Association

1987 - 1989
Fulbright Senior Lecturing Award

1981
Merck Award for Medical Student Achievement

1980
Borts Student Research Award

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Patents

Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
U.S. Serial #: 14/297,137
Filed: Jun 05, 2014
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Physician Checklists for FSHD (Facioscapulohumeral Muscular Dystrophy) and DM (Myotonic Dystrophy)
U.S. Serial #: 1-686888271
Filed: Nov 16, 2011
Invented By: Michael McDermott, Richard Moxley, III, Al-Rabi Tawil, Charles Thornton

Title: Patient Information Forms for FSHD (Facioscapulohumeral Muscular Dystrophy), DM (Myotonic Dystrophy), and Unaffected Blood Relatives of Individuals with FSH
U.S. Serial #: 1-686948337
Filed: Nov 16, 2011
Invented By: Michael McDermott, Richard Moxley, III, Al-Rabi Tawil, Charles Thornton

Title: Compositions and Methods Related to Protein Displacement Therapy For Myotonic Dystrophy
U.S. Serial #: 12/442,354
Filed: Sep 21, 2007
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy
U.S. Serial #: 2007297535
Filed: Sep 21, 2007
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
U.S. Serial #: 2,664,189
Filed: Sep 21, 2007
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
U.S. Serial #: 2009-529258
Filed: Sep 21, 2007
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy
U.S. Serial #: 2014216025
Filed: Sep 21, 2007
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy
U.S. Serial #: GB12005320.2
Filed: Sep 21, 2007
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
U.S. Serial #: 2016-75837
Filed: Sep 21, 2007
Invented By: Jill Miller, Robert Osborne, Krzysztof Sobczak, Maurice Swanson, Charles Thornton, Thurman Wheeler

Title: Methods and Compositions for Treatment of Myotonia
U.S. Serial #: 10/591,883
Filed: Mar 10, 2005
Invented By: Rahul Kanadia, Maurice Swanson, Charles Thornton

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Publications

Journal Articles

4/24/2018
Hilbert JE, Thornton CA, Moxley RT. "Author response: High frequency of gastrointestinal manifestations in myotonic dystrophy type 1 and type 2." Neurology.. 2018 Apr 24; 90(17):814.

4/17/2018
Sznajder ?J, Thomas JD, Carrell EM, Reid T, McFarland KN, Cleary JD, Oliveira R, Nutter CA, Bhatt K, Sobczak K, Ashizawa T, Thornton CA, Ranum LPW, Swanson MS. "Intron retention induced by microsatellite expansions as a disease biomarker." Proceedings of the National Academy of Sciences of the United States of America.. 2018 Apr 17; 115(16):4234-4239. Epub 2018 Apr 02.

4/10/2018
Thadke S, Perera JDR, Hridya VM, Bhatt K, Shaikh AY, Hsieh WC, Chen MD, Gayathri C, Gil RR, Rule GS, Mukherjee A, Thornton CA, Ly DH. "Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington's Disease." Biochemistry.. 2018 Apr 10; 57(14):2094-2108. Epub 2018 Mar 27.

Books & Chapters

2011
Chapter Title: Myotonic Dystrophy
Book Title: Muscle: Fundamental Biology and Mechanisms and Disease
Author List: Thornton, CA
Edited By: Hill JA, Stull JT, Sweeney HL, Olson, EN
Published By: Elsevier 2011

2009
Chapter Title: Myotonic Dystrophy
Book Title: Disorders of Voluntary Muscle
Author List: Day J, Thornton C
Edited By: Karpati G, Hilton-Jones D, Bushbby K, Griggs RC
Published By: Cambridge University Press 2009 in Cambridge UK

2006
Chapter Title: The RNA-Mediated Disease Process in Myotonic Dystrophy
Book Title: Genetic Instabilities and Neurological Diseases
Author List: Thornton CA, Swanson MS, Cooper TA
Edited By: Wells R, Ashizawa T
Published By: Elsevier 2006 in San Diego, CA

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