J Scott Butler, Ph.D.

J Scott Butler, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Office: (585) 275-7921
Lab: (585) 275-5614
Fax: (585) 473-9573

Journal Articles

Showing all 38 journal articles available.

2015 Apr
Jin G, Pavelka MS, Butler JS. "Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module." Journal of bacteriology. 2015 Apr; 197(7):1197-207. Epub 2015 Jan 26.
Hamilton B, Manzella A, Schmidt K, DiMarco V, Butler JS. "Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site." PloS one. 2014 9(11):e112921. Epub 2014 Nov 12.
Schmidt K, Butler JS. "Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity." Wiley interdisciplinary reviews. RNA. 2013 4(2):217-31. Epub 2013 Feb 15.
2012 Oct
Schmidt K, Xu Z, Mathews DH, Butler JS. "Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance." RNA. 2012 Oct; 18(10):1934-45. Epub 2012 Aug 24.
2011 Apr
Alam A, Miller KA, Chaand M, Butler JS, Dziejman M. "Identification of Vibrio cholerae type III secretion system effector proteins." Infection and immunity. 2011 Apr; 79(4):1728-40. Epub 2011 Jan 31.
Butler JS, Mitchell P. "Rrp6, rrp47 and cofactors of the nuclear exosome." Advances in experimental medicine and biology. 2011 702:91-104.
2010 Feb 5
Callahan KP, Butler JS. "TRAMP complex enhances RNA degradation by the nuclear exosome component Rrp6." The Journal of biological chemistry. 2010 Feb 5; 285(6):3540-7. Epub 2009 Dec 02.
Butler JS, Mitchell P. "Rrp6, Rrp47 and cofactors of the nuclear exosome." Advances in experimental medicine and biology. 2010 702:91-104.
2009 Jun
Roth KM, Byam J, Fang F, Butler JS. "Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex." RNA. 2009 Jun; 15(6):1045-58. Epub 2009 Apr 15.
2008 May
Hoskins J, Butler JS. "RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p." Genetics. 2008 May; 179(1):323-30.
Callahan KP, Butler JS. "Lifting the veil on the transcriptome." Genome biology. 2008 9(4):218.
Callahan KP, Butler JS. "Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p." Nucleic acids research. 2008 36(21):6645-55. Epub 2008 Oct 21.
2005 Oct
Fang F, Phillips S, Butler JS. "Rat1p and Rai1p function with the nuclear exosome in the processing and degradation of rRNA precursors." RNA. 2005 Oct; 11(10):1571-8. Epub 2005 Aug 30.
2005 Mar
Roth KM, Wolf MK, Rossi M, Butler JS. "The nuclear exosome contributes to autogenous control of NAB2 mRNA levels." Molecular and cellular biology. 2005 Mar; 25(5):1577-85.
2004 Jun 8
Kuai L, Fang F, Butler JS, Sherman F. "Polyadenylation of rRNA in Saccharomyces cerevisiae." Proceedings of the National Academy of Sciences of the United States of America. 2004 Jun 8; 101(23):8581-6. Epub 2004 Jun 01.
2004 Jan 9
Lum PY, Armour CD, Stepaniants SB, Cavet G, Wolf MK, Butler JS, Hinshaw JC, Garnier P, Prestwich GD, Leonardson A, Garrett-Engele P, Rush CM, Bard M, Schimmack G, Phillips JW, Roberts CJ, Shoemaker DD. "Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes." Cell. 2004 Jan 9; 116(1):121-37.
Fang F, Hoskins J, Butler JS. "5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs." Molecular and cellular biology. 2004 24(24):10766-76.
2003 Sep
Phillips S, Butler JS. "Contribution of domain structure to the RNA 3' end processing and degradation functions of the nuclear exosome subunit Rrp6p." RNA. 2003 Sep; 9(9):1098-107.
2003 Aug
Das B, Butler JS, Sherman F. "Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae." Molecular and cellular biology. 2003 Aug; 23(16):5502-15.
2002 Feb
Butler JS. "The yin and yang of the exosome." Trends in cell biology. 2002 Feb; 12(2):90-6.
2000 Jan
Burkard KT, Butler JS. "A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p." Molecular and cellular biology. 2000 Jan; 20(2):604-16.
1998 May 22
Briggs MW, Burkard KT, Butler JS. "Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation." The Journal of biological chemistry. 1998 May 22; 273(21):13255-63.
1997 Jun
Liang S, Briggs MW, Butler JS. "Regulation of tRNA suppressor activity by an intron-encoded polyadenylation signal." RNA. 1997 Jun; 3(6):648-59.
1997 Feb 28
Proweller A, Butler JS. "Ribosome concentration contributes to discrimination against poly(A)- mRNA during translation initiation in Saccharomyces cerevisiae." The Journal of biological chemistry. 1997 Feb 28; 272(9):6004-10.
1996 Jul
Briggs MW, Butler JS. "RNA polymerase III defects suppress a conditional-lethal poly(A) polymerase mutation in Saccharomyces cerevisiae." Genetics. 1996 Jul; 143(3):1149-61.
1996 May 3
Proweller A, Butler JS. "Ribosomal association of poly(A)-binding protein in poly(A)-deficient Saccharomyces cerevisiae." The Journal of biological chemistry. 1996 May 3; 271(18):10859-65.
1995 May 9
Guo Z, Russo P, Yun DF, Butler JS, Sherman F. "Redundant 3' end-forming signals for the yeast CYC1 mRNA." Proceedings of the National Academy of Sciences of the United States of America. 1995 May 9; 92(10):4211-4.
1994 Nov 1
Proweller A, Butler S. "Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae." Genes & development. 1994 Nov 1; 8(21):2629-40.
1992 Jul
Patel D, Butler JS. "Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase." Molecular and cellular biology. 1992 Jul; 12(7):3297-304.
1991 Jul 11
Sadhale PP, Sapolsky R, Davis RW, Butler JS, Platt T. "Polymerase chain reaction mapping of yeast GAL7 mRNA polyadenylation sites demonstrates that 3' end processing in vitro faithfully reproduces the 3' ends observed in vivo." Nucleic acids research. 1991 Jul 11; 19(13):3683-8.
1990 Jun
Butler JS, Sadhale PP, Platt T. "RNA processing in vitro produces mature 3' ends of a variety of Saccharomyces cerevisiae mRNAs." Molecular and cellular biology. 1990 Jun; 10(6):2599-605.
Butler JS, Platt T. "RNA processing generates the mature 3' end of yeast CYC1 messenger RNA in vitro." Science. 1988 242(4883):1270-4.
1987 Jun
Butler JS, Springer M, Grunberg-Manago M. "AUU-to-AUG mutation in the initiator codon of the translation initiation factor IF3 abolishes translational autocontrol of its own gene (infC) in vivo." Proceedings of the National Academy of Sciences of the United States of America. 1987 Jun; 84(12):4022-5.
1986 Jun
Springer M, Graffe M, Butler JS, Grunberg-Manago M. "Genetic definition of the translational operator of the threonine-tRNA ligase gene in Escherichia coli." Proceedings of the National Academy of Sciences of the United States of America. 1986 Jun; 83(12):4384-8.
1986 Jan
Butler JS, Springer M, Dondon J, Grunberg-Manago M. "Posttranscriptional autoregulation of Escherichia coli threonyl tRNA synthetase expression in vivo." Journal of bacteriology. 1986 Jan; 165(1):198-203.
Butler JS, Springer M, Dondon J, Graffe M, Grunberg-Manago M. "Escherichia coli protein synthesis initiation factor IF3 controls its own gene expression at the translational level in vivo." Journal of molecular biology. 1986 192(4):767-80.
1985 Sep 5
Springer M, Plumbridge JA, Butler JS, Graffe M, Dondon J, Mayaux JF, Fayat G, Lestienne P, Blanquet S, Grunberg-Manago M. "Autogenous control of Escherichia coli threonyl-tRNA synthetase expression in vivo." Journal of molecular biology. 1985 Sep 5; 185(1):93-104.
1984 Feb 28
Butler JS, Clark JM. "Eucaryotic initiation factor 4B of wheat germ binds to the translation initiation region of a messenger ribonucleic acid." Biochemistry. 1984 Feb 28; 23(5):809-15.