Trevor J. Shuttleworth, Ph.D.

Trevor J. Shuttleworth, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Fax: (585) 273-2652
Lab: (585) 275-3431
Office: (585) 275-2076

Research Bio

The cellular actions of many neurotransmitters and hormones are dependent on receptor-activated increases in intracellular calcium concentrations in their target cells. In various secretory and other "non-excitable" cells, the physiologically relevant signals often take the form of a series of Ca2+ oscillations, and many critical cellular responses are tuned to respond to the specific frequency of such oscillations. A key factor in sustaining these signals and determining their frequency, is the receptor-activated entry of Ca2+ from the extracellular medium. Our research concerns the nature of the conductances responsible for this entry, and their specific roles in modulating the overall Ca2+ signal. Specifically, our recent research has focused on the ARC channel – a novel Ca2+ entry channel that is activated by the receptor-mediated generation of arachidonic acid, and which we first described a few years ago. Importantly, it is this channel that appears to play the major role in the entry of Ca2+ during the generation of the oscillatory Ca2+ signals in several cell types. We have recently characterized the key molecular components of this channel, revealing that it is a member of a new family of channels – the "Orai-based channels". This molecular characterization has opened up new opportunities for the analysis of its nature, mechanism of activation, and regulation. This, along with identifying how the Ca2+ entering via this channel acts to modulate the frequency of the agonist-induced Ca2+ oscillations, forms the major focus of our current research.

Techniques used include patch-clamp analysis of ion-channel activity, digital imaging, real-time confocal imaging, and photon-counting microfluorimetric measurements of intracellular Ca2+ concentrations in single cells, and biochemical and molecular studies of the proteins that form the channel and its regulators.

Awards & Honors (Local)

Chair and Organizer, Satellite Symposium on "Orai Channels--New Insights, New Ideas" | 56th Annual Biophysical Society Meeting | San Diego, California 2012
Plenary Speaker, Ion Channel Signaling Mechanisms: from Basic Science to Clinical Applications | Marrakesh, Morocco 2011 - 2011
Session Chair - Salivary Glands and Saliva | Gordon Research Conference | Ventura, California 2003
Session Chair - 5th UK Calcium Signalling Conference, Liverpool, England. 2003
Session Chair - Professor Sir Michael Berridge Retirement Conference, Cambridge, England. 2003
Session Chair - International Workshop on "Experimental and Theoretical Calcium Dynamics" Max-Planck institute for the Physics of Complex Systems, Dresden, Germany 2000
Session Chair - Experimental Biology 1993 (FASEB) meeting, New Orleans 1993
Session Chair - Joint Meeting of the APS, ASZ, CSZ and SEB, Cambridge, England 1992
Session Chair - International Symposium on "Mechanisms of Systemic Regulation in Lower Vertebrates", Göttingen, Germany 1990
Session Chair - Society for Experimental Biology Conference, York, U.K. 1987
Session Chair - IUPS International Congress, Vancouver, Canada 1986
Session Chair - IUPS Satellite Symposium on "Membrane Transport and Control: Comparative Mechanisms", Banff, Canada 1986
Session Chair - Society for Experimental Biology Conference, Bangor, U.K. 1985
Session Chair - Society for Experimental Biology Conference, Cardiff, U.K. 1984
Session Chair - Seminar Series Symposium of the Society for Experimental Biology, Durham, U.K. 1981
Session Chair - Society for Experimental Biology Conference, Lancaster, U.K. 1979
Science Research Council Fellowship (U.K.), University of Lancaster, England 1972 - 1974
University of Otago Teaching Fellowship, University of Otago, New Zealand 1969 - 1972

Recent Journal Articles

Showing the 5 most recent journal articles. 104 available »

2015 Feb 1
Thompson JL, Shuttleworth TJ. "Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel." The Journal of physiology. 2015 Feb 1; 593(3):559-72. Epub 2015 Jan 07.
2014 Jul
Duquette M, Nadler M, Okuhara D, Thompson J, Shuttleworth T, Lawler J. "Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity." Matrix biology : journal of the International Society for Matrix Biology. 2014 Jul; 37:15-24. Epub 2014 May 16.
Thompson, JL; Shuttleworth, TJ. "How many Orai's does it take to make a CRAC channel?". Nature Scientific Reports. 2013; 3: 1961.
Thompson, JL; Shuttleworth, TJ. "Molecular basis of activation of the arachidonate-regulated ARC channel, a store-independent Orai channel, by plasma membrane STIM1". The Journal of Physiology. 2013; 591: 3507-3523.
Thompson, JL.; Shuttleworth, TJ. "Exploring the unique features of the ARC channel, a store-independent Orai channel". Channels. 2013; 7: 364-373.

Current Appointments

Professor - Department of Pharmacology and Physiology (SMD) - Primary


PhD | Zoology/Comp. Physiology | New Zealand-Univ of Otago1972
BS | Zoology | UK-Univ of London1968

Post-Doctoral Training & Residency

SRC Research Associate, Department of Biological Sciences, University of Lancaster, England 1974