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Trevor J. Shuttleworth, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-2076

Fax: (585) 273-2652

Biography

Research

The cellular actions of many neurotransmitters and hormones are dependent on receptor-activated increases in intracellular calcium concentrations in their target cells. In various secretory and other "non-excitable" cells, the physiologically relevant signals often take the form of a series of Ca2+ oscillations, and many critical cellular responses are tuned to respond to the specific frequency of such oscillations. A key factor in sustaining these signals and determining their frequency, is the receptor-activated entry of Ca2+ from the extracellular medium. Our research concerns the nature of the conductances responsible for this entry, and their specific roles in modulating the overall Ca2+ signal. Specifically, our recent research has focused on the ARC channel – a novel Ca2+ entry channel that is activated by the receptor-mediated generation of arachidonic acid, and which we first described a few years ago. Importantly, it is this channel that appears to play the major role in the entry of Ca2+ during the generation of the oscillatory Ca2+ signals in several cell types. We have recently characterized the key molecular components of this channel, revealing that it is a member of a new family of channels – the "Orai-based channels". This molecular characterization has opened up new opportunities for the analysis of its nature, mechanism of activation, and regulation. This, along with identifying how the Ca2+ entering via this channel acts to modulate the frequency of the agonist-induced Ca2+ oscillations, forms the major focus of our current research.

Techniques used include patch-clamp analysis of ion-channel activity, digital imaging, real-time confocal imaging, and photon-counting microfluorimetric measurements of intracellular Ca2+ concentrations in single cells, and biochemical and molecular studies of the proteins that form the channel and its regulators.

Credentials

Faculty Appointments

Education

1972
PhD | New Zealand-Univ of Otago
Zoology/Comp. Physiology

1968
BS | UK-Univ of London
Zoology

Awards

2012
Chair and Organizer, Satellite Symposium on "Orai Channels--New Insights, New Ideas"
Sponsor: 56th Annual Biophysical Society Meeting
Location: San Diego, California

2011 - 2011
Plenary Speaker, Ion Channel Signaling Mechanisms: from Basic Science to Clinical Applications
Location: Marrakesh, Morocco

2003
Session Chair - Professor Sir Michael Berridge Retirement Conference, Cambridge, England.

2003
Session Chair - 5th UK Calcium Signalling Conference, Liverpool, England.

2003
Session Chair - Salivary Glands and Saliva
Sponsor: Gordon Research Conference
Location: Ventura, California

2000
Session Chair - International Workshop on "Experimental and Theoretical Calcium Dynamics" Max-Planck institute for the Physics of Complex Systems, Dresden, Germany

1993
Session Chair - Experimental Biology 1993 (FASEB) meeting, New Orleans

1992
Session Chair - Joint Meeting of the APS, ASZ, CSZ and SEB, Cambridge, England

1990
Session Chair - International Symposium on "Mechanisms of Systemic Regulation in Lower Vertebrates", Göttingen, Germany

1987
Session Chair - Society for Experimental Biology Conference, York, U.K.

1986
Session Chair - IUPS International Congress, Vancouver, Canada

1986
Session Chair - IUPS Satellite Symposium on "Membrane Transport and Control: Comparative Mechanisms", Banff, Canada

1985
Session Chair - Society for Experimental Biology Conference, Bangor, U.K.

1984
Session Chair - Society for Experimental Biology Conference, Cardiff, U.K.

1981
Session Chair - Seminar Series Symposium of the Society for Experimental Biology, Durham, U.K.

1979
Session Chair - Society for Experimental Biology Conference, Lancaster, U.K.

1972 - 1974
Science Research Council Fellowship (U.K.), University of Lancaster, England

1969 - 1972
University of Otago Teaching Fellowship, University of Otago, New Zealand

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Publications

Journal Articles

5/2017
Shuttleworth TJ. "Selective activation of distinct Orai channels by STIM1." Cell calcium.. 2017 May 0; 63:40-42. Epub 2016 Nov 04.

2/1/2015
Thompson JL, Shuttleworth TJ. "Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel." The Journal of physiology.. 2015 Feb 1; 593(3):559-72. Epub 2015 Jan 07.

7/2014
Duquette M, Nadler M, Okuhara D, Thompson J, Shuttleworth T, Lawler J. "Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity." Matrix biology : journal of the International Society for Matrix Biology.. 2014 Jul 0; 37:15-24. Epub 2014 May 16.

Books & Chapters

2016
Chapter Title: Orai Channels
Book Title: Ion Channels and Transporters in of Epithelia in Health and Disease
Author List: Shuttleworth, TJ
Edited By: Hamilton, K.L; Devor, D.C.
Published By: Springer2016

2013
Chapter Title: ARC channels – an endogenous store-independent Orai channel
Book Title: Current Topics in Membranes
Author List: Thompson, JL; Mignen, O; Shuttleworth, TJ
Edited By: Prakriya, M
Published By: Elsevier Press2013

2009
Chapter Title: Arachidonic acid-regulated Ca2+ channel
Book Title: Handbook of Cell Signaling
Author List: Shuttleworth, TJ
Edited By: Bradshaw, R; Dennis, E
Published By: Academic Press2009

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