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P Anthony DiSantagnese, M.D.

Contact Information

Phone Numbers

Office: (585) 275-0839

Fax: (585) 273-3637

Research Labs

The Genitourinary Pathology Section (GUPS) at the URMC Department of Pathology and Laboratory Medicine has a special interest in the neuroendocrine prostate.

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Faculty Appointments


Dr. di Sant'Agnese's clinical and research expertise is in the field of prostate cancer. His clinical interests include general surgical pathology with special expertise in genitourinary pathology; the application of immunohistochemistry to diagnostic surgical pathology; and standardization of reporting for surgical specimens.


Research has included the investigation of the prostatic neuroendocrine cell and neuroendocrine differentiation in prostatic carcinoma. Past studies include seminal descriptive morphologic investigations as well as clinical-pathological correlative studies using such techniques as immunohistochemistry, in-situ hybridization, electron microscopy and immunoelectron microscopy. Our group was the first to describe several peptide hormone products of prostatic neuroendocrine cells as well as the ultrastructural morphology of neuroendocrine cell types. Other research has included tissue, tumor and serum quantitative and correlative studies of neuroendocrine products in both humans and animals. More recently, we have begun to investigate, both in vitro and in vivo, the regulatory mechanisms involved in, and phenotypic effects of, prostatic neuroendocrine differentiation using prostatic cancer cell lines and transgenic/knockout mouse models. For further details see our Neuroendocrine Prostate web site, listed below.



BA | Amherst College

MD | Columbia Univ Coll P&s

Post-doctoral Training & Residency

07/01/1975 - 06/30/1979
Internship in Pathology & Laboratory Medicine at Columbia Presbyterian Medical Center

07/01/1975 - 06/30/1979
Residency in Pathology & Laboratory Medicine at Columbia Presbyterian Medical Center


Harold Lee Meierhof Memorial Prize for Excellence in Pathology (Columbia University P&S Graduation Award)

B.A. Cum Laude, Amherst College

High School Class Valedictorian, Landon School, Bethesda, MD

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Journal Articles

Subik MK, Gordetsky J, Yao JL, di Sant'agnese PA, Miyamoto H. "Frozen section assessment in testicular and paratesticular lesions suspicious for malignancy: its role in preventing unnecessary orchiectomy." Human pathology.. 2012 Sep 0; 43(9):1514-9. Epub 2012 Mar 08.

Subik MK, Yao JL, di Sant'agnese PA, Miyamoto H. "The role of periprostatic and periseminal vesicle lymph node metastasis in the staging and prognosis of prostate cancer." Histopathology.. 2012 May 0; 60(6):1009-10. Epub 2012 Feb 28.

Messing E, Gee JR, Saltzstein DR, Kim K, Disant'agnese A, Kolesar J, Harris L, Faerber A, Havighurst T, Young JM, Efros M, Getzenberg RH, Wheeler MA, Tangrea J, Parnes H, House M, Busby JE, Hohl R, Bailey H. "A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients." Cancer prevention research.. 2012 Apr 0; 5(4):621-30. Epub 2012 Jan 31.

Books & Chapters

Chapter Title: Neuroendocrine tumors in Tumors of the Urinary System and Male Genital Organs.
Book Title: World Health Organization Classification of Tumors
Author List: di Sant'Agnese, PA; Egevad, L; Epstein, JI; Helpap, B; Humphrey, PA; et al.
Published By: IARC Press 2004

Chapter Title: Neuroendocrine Differentiation in Prostate Cancer: An overview. In Advances in Oncology: The Expanding Role of Octreotide.
Book Title: . In Advances in Oncology: The Expanding Role of Octreotide.
Author List: Huang, J; di Sant'Agnese, PA.
Edited By: SWJ Lamberts
Published By: BioScientifica Ltd, Bristol 2002

Chapter Title: Neuroendocrine differentiation in Prostate Carcinoma: An update on Recent Developments.
Book Title: Annals of Oncology
Author List: di Sant'Agnese, PA.
Published By: Annals of Oncology 2001