P Anthony DiSantagnese, M.D.

P Anthony DiSantagnese, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 275-0839
Fax: (585) 273-3637

Lab Information

The Genitourinary Pathology Section (GUPS) at the URMC Department of Pathology and Laboratory Medicine has a special interest in the neuroendocrine prostate.

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Research Bio

Research has included the investigation of the prostatic neuroendocrine cell and neuroendocrine differentiation in prostatic carcinoma. Past studies include seminal descriptive morphologic investigations as well as clinical-pathological correlative studies using such techniques as immunohistochemistry, in-situ hybridization, electron microscopy and immunoelectron microscopy. Our group was the first to describe several peptide hormone products of prostatic neuroendocrine cells as well as the ultrastructural morphology of neuroendocrine cell types. Other research has included tissue, tumor and serum quantitative and correlative studies of neuroendocrine products in both humans and animals.

More recently, we have begun to investigate, both in vitro and in vivo, the regulatory mechanisms involved in, and phenotypic effects of, prostatic neuroendocrine differentiation using prostatic cancer cell lines and transgenic/knockout mouse models. For further details see our Neuroendocrine Prostate web site, listed below.

Awards & Honors (Local)

Harold Lee Meierhof Memorial Prize for Excellence in Pathology (Columbia University P&S Graduation Award) 1975
B.A. Cum Laude, Amherst College 1971
High School Class Valedictorian, Landon School, Bethesda, MD 1967

Recent Journal Articles

Showing the 5 most recent journal articles. 127 available »

2012 Sep
Subik MK, Gordetsky J, Yao JL, di Sant'agnese PA, Miyamoto H. "Frozen section assessment in testicular and paratesticular lesions suspicious for malignancy: its role in preventing unnecessary orchiectomy." Human pathology. 2012 Sep; 43(9):1514-9. Epub 2012 Mar 08.
2012 May
Subik MK, Yao JL, di Sant'agnese PA, Miyamoto H. "The role of periprostatic and periseminal vesicle lymph node metastasis in the staging and prognosis of prostate cancer." Histopathology. 2012 May; 60(6):1009-10. Epub 2012 Feb 28.
2012 Apr
Messing E, Gee JR, Saltzstein DR, Kim K, Disant'agnese A, Kolesar J, Harris L, Faerber A, Havighurst T, Young JM, Efros M, Getzenberg RH, Wheeler MA, Tangrea J, Parnes H, House M, Busby JE, Hohl R, Bailey H. "A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients." Cancer prevention research. 2012 Apr; 5(4):621-30. Epub 2012 Jan 31.
2011 May
Arbini AA, Greco M, Yao JL, Bourne P, Marra E, Hsieh JT, di Sant'agnese PA, Moro L. "Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer." The American journal of pathology. 2011 May; 178(5):2367-76.
2009 Apr
Moro L, Arbini AA, Yao JL, di Sant'Agnese PA, Marra E, Greco M. "Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2." Cell death and differentiation. 2009 Apr; 16(4):571-83. Epub 2008 Dec 12.

Current Appointments

Professor Emeritus - Department of Pathology and Laboratory Medicine (SMD) - Primary


Anatomic Pathology - American Board of Pathology


MD | Medicine | Columbia Univ Coll P&s1975
BA | Biology | Amherst College1971

Post-Doctoral Training & Residency

Chief Resident in Pathology, Presbyterian Hospital, New York, New York 1979
Resident in Pathology, Presbyterian Hospital, New York, New York 1979
Visiting Clinical Fellow, Columbia University P&S 1979
Intern in Pathology, Presbyterian Hospital, New York, New York 1976