Nicholas Jospe, M.D.

Nicholas Jospe, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester, NY 14642

Office: (585) 275-7744
Fax: (585) 244-6097

Research Bio

Dr. Jospe is engaged in clinical research aimed at preventing Type 1 diabetes and studying the underlying mechanisms causing Type 1 diabetes. He is an investigator in "TrialNet", an international study funded by the NIH and other organizations, investigating the natural history of Type 1 diabetes and possible interventions to prevent diabetes in individuals at high risk. He has partnered locally with the "Autoimmunity Center of Excellence" at the University of Rochester, as well as the Benaroya Research Institute, Virginia Mason Medical Center, Seattle WA, where he is currently on sabbatical. He is co-investigator in a multi-center industry sponsored study investigating the utility of continuous glucose sensor technology in the care of children with Type 1 diabetes.

Awards & Honors (Local)

Diabetes Award in Adolescent Health | Society for Adolescent Medicine and Carlotta Simons 2003
American Diabetes Association Certificate of Recognition | American Diabetes Association 2002
JDRF "Inspiration Award" | JDRF 2002

Recent Journal Articles

Showing the 5 most recent journal articles. 35 available »

2016 Jan 1
Kryvalap Y, Lo CW, Manuylova E, Baldzizhar R, Jospe N, Czyzyk J. "Antibody Response to Serpin B13 Induces Adaptive Changes in Mouse Pancreatic Islets and Slows Down the Decline in the Residual Beta Cell Function in Children with Recent Onset of Type 1 Diabetes Mellitus." The Journal of biological chemistry. 2016 Jan 1; 291(1):266-78. Epub 2015 Nov 17.
Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT. "Avidity-dependent programming of autoreactive T cells in T1D." PloS one. 2014 9(5):e98074. Epub 2014 May 20.
2011 Nov
Mallone R, Scotto M, Janicki CN, James EA, Fitzgerald-Miller L, Wagner R, Gottlieb P, Thorpe J, Jospe N, Durinovic-Bellò I, Boitard C, Lou O, Dayan CM, Wong FS, . "Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative." Diabetes/metabolism research and reviews. 2011 Nov; 27(8):720-6.
2011 Nov
James EA, Mallone R, Schloot NC, Gagnerault MC, Thorpe J, Fitzgerald-Miller L, Reichow J, Wagner R, Pham MN, Jospe N, Lou O, Gottlieb PA, Brooks-Worrell BM, Durinovic-Belló I, . "Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative." Diabetes/metabolism research and reviews. 2011 Nov; 27(8):727-36.
2011 Aug
Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell DJ. "Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes." Diabetes. 2011 Aug; 60(8):2125-33. Epub 2011 Jun 29.

Current Appointments

Professor - Department of Pediatrics, Endocrinology (SMD) - Primary


Pediatric Endocrinology - American Board of Pediatrics
Pediatrics - American Board of Pediatrics


MD | Medicine | Free University of Brussels Medical School1981
BA | Biology | Boston University1974

Post-Doctoral Training & Residency

Fellowship in Pediatric Endocrinology at Johns Hopkins Hospital - GME Office07/01/1984 - 06/30/1988
Residency in Pediatrics at Brookdale Hospital Medical Center07/01/1982 - 06/30/1984
Internship in Pediatrics at Brookdale Hospital Medical Center07/01/1981 - 06/30/1982