Michael E. Pichichero, M.D.

Michael E. Pichichero, M.D.

Contact Information

Legacy Pediatrics
1815 South Clinton Avenue
Rochester, NY 14618

Office: (585) 244-9720
Fax: (585) 244-9995

Research Bio

Dr. Pichichero and his colleagues' vaccine studies helped define the key variables that determine immunogenicity of the Haemophilus influenzae b (Hib) conjugate vaccines in the young infant. Encouraging findings have been made with Streptococcus pneumoniae capsular polysaccharide vaccines of several serotypes employing the conjugate vaccine technology. Continuation of these studies should further define structural factors governing immunogenicity of conjugate vaccines, analyze the role of epitopes of the carrier component, and pursue structure-immunogenicity relationships in conjugates of specific pneumococcal serotypes.

Combination vaccines are a necessity for the future of human vaccine development. The immunogenicity of acellular pertussis (DTaP) vaccines combined with various Hib conjugate vaccines, Hepatitis B vaccine, and inactivated poliovirus vaccine results in reduced immunogenicity for some of the included antigens. The mechanism(s) and biological relevance of this immunologic interference phenomena is an area of active research in Dr. Pichichero's lab.
Bacteria resistant to standard antibiotic therapy are causing acute otitis media with increasing frequency. New antibiotics are needed to cure these infections and to prevent long-term middle ear disease and associated hearing loss. Dr. Pichichero's group studies the epidemiology, etiology, and optimal treatment of otitis media. Sore throat caused by Group A beta hemolytic streptococci occur with concomitant colonization by organisms that may protect the streptococci through beta lactamase inactivation of penicillin at the site of infection. Dr. Pichichero's group evaluates alternative treatments to decrease the relapse rate of streptococcal infections.
Recent Publications
Pichichero ME "The Importance of Bacteriologic Eradication in the Treatment of Group A Streptococcal Tonsillopharyngitis." Clin Pediatr (Phila). 2007 May;46(4_suppl):3S-16S
Casey JR, Pichichero ME. "Symptomatic Relapse of Group A {beta}-Hemolytic Streptococcal Tonsillopharyngitis in Children." Clin Pediatr (Phila). 2007 May;46(4):307-10
Pichichero ME "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):S13-8
Pichichero ME. "Who should get the HPV vaccine?" J Fam Pract. 2007 Mar;56(3):197-202
Casey JR, Pichichero ME. "Safe use of selected cephalosporins in penicillin-allergic patients: A meta-analysis." Otolaryngol Head Neck Surg. 2007 Mar;136(3):340-7.
Casey JR, Pichichero ME. "The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis." Diagn Microbiol Infect Dis. 2007 Feb 8;
Zeng M, Xu Q, Pichichero ME. "Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine." Vaccine. 2007 Jan 26;

Publication list, as provided by PubMed.
PubMed is maintained by the National Library of Medicine and provides complete abstracts of all publications,
as well as links to the full text of many articles (at journal homepages).

Awards & Honors (Local)

Pediatric Infectious Disease Society of US, Breese Award for Outstanding Contribution to Clinical Research, Teaching and Practice, 2005 2005
Top Physicians in America-2004, 2005, 2006, 2007 2004 - 2007
Best Doctors in America, 2002, 2003, 2004, 2005, 2006, 2007 2002 - 2007
Best Pediatricians in America, 2002, 2003, 2004, 2005, 2006, 2007 2002 - 2007
Alpha Omega Alpha, 1976 1976
Phi Beta Kappa 1972

Recent Journal Articles

Showing the 5 most recent journal articles. 33 available »

Pichichero ME. "Preventing Cervical Cancer: Who should get the HPV vaccine? Latest recommendations from ACIP and others." J Fam Pract 2007; 56(3):197-202. 2007; .
Pichichero ME. "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift." Diagn Microbio Infect Dis 2007;57(3) Suppl 1:S13-S18. 2007; .
Zeng M., Pichichero ME. "Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine." Science Direct 2007;25:3588-3594. 2007; .
Nicolau DP, Sutherland CA, Arguedas A, Dagan R, Pichichero ME. "Pharmacokinetics of Cefprozil in Plasma and Middle Ear Fluid." Pediatr Drugs 2007; 9(2):119-123. 2007; .
Farrell DJ, Klugman KP, Pichichero ME. "Increased Antimicrobial Resistance Among Nonvaccine Serotypes of Streptococcus pneumoniae in the Pediatric Population after the Introduction of 7-Valent Pneumococcal Vaccine in the United States." Pediat Inf Dis J 2007; 26(2)123-128. 2007; .

Current Appointments

Clinical Professor - Department of Pediatrics (SMD) - Primary


Allergy and Immunology - American Board of Allergy and Immunology
Pediatric Infectious Diseases - American Board of Pediatrics
Pediatrics - American Board of Pediatrics


MD | Medicine | Univ Rochester Sch Med/Dent1976
BA | Biological Science | Rutgers State University1972

Post-Doctoral Training & Residency

Fellowship in Pediatric Infectious Disease at University of Colorado Health Sciences Center07/01/1979 - 06/30/1981
Residency in Pediatrics at University of Rochester Medical Center07/01/1977 - 06/30/1979
Internship in Pediatrics at University of Colorado Health Sciences Center07/01/1976 - 06/30/1977