William J. Bowers, Ph.D.

William J. Bowers, Ph.D.

Contact Information

SUNY Oswego
Office of Research and Sponsored Programs
7060 State Route 104
Oswego, NY 13126

Office: (315) 312-5631

Research Bio

The Bowers laboratory is interested in assessing the contribution of inflammation in the context of Alzheimer's disease (AD) pathophysiology. Novel transgenic modeling and gene transfer-based methodologies are being employed to experimentally control the expression and/or activity of potent inflammatory cytokines/chemokines due to their purported role(s) in brain inflammation and neurodegeneration. Elucidating the role of inflammation in the AD pathogenic cascade will undoubtedly result in the development of novel diagnostic methodologies and stage-specific therapeutics. The laboratory's line of research addresses both the role of inflammation temporally and spatially in pathogenesis as well as examines the interplay between disease-modifying therapies and inflammation to either slow or exacerbate neurodegeneration.

The laboratory also develops novel vaccines and therapeutics based upon the Herpes simplex virus (HSV) amplicon vector platform for future clinical implementation. Amplicon vectors are attractive because they may be manipulated to express virtually any combination of genes and possess the largest transgene capacity of any virus vector in current use. The laboratory continues to refine amplicon-based therapeutics in preclinical disease models and is currently engaged in translation of amplicon-based therapies for Phase I clinical trial evaluation. The laboratory has recently adapted the amplicon vector platform for efficient and long-term molecular manipulation of neural stem cells during embryogenesis in situ, thus providing a novel and robust means for gene replacement/repair in neurodegenerative diseases arising during early mammalian development.

Awards & Honors (Local)

Development of Improved HSV Amplicon Vectors NIH Individual NRSA Postdoctoral Fellowship: #1-F2-NS10299-01 1997 - 1998
Murine Cardiac Neural Crest Derivatives: Examining the Developmental Role for NGF American Heart Association-NYS Affiliate Postdoctoral Fellowship:" #960102 1996 - 1997
Pathogenesis of Bacteria and Viruses NIH Predoctoral Training Grant: #5-T32-AI07362 1992 - 1995


Novel Gene Therapy for Cell Death and Dysfunction

United States Serial NO.: 14/131,947
Filed Date: July 12, 2012
Title: Treating Neurological Disease or Injury with a Dynamin-Related Protein 1 (DRP1) Encoding Nucleic Acid
Invented by: Kim Tieu, William Bowers, Phillip Rappold

Recent Journal Articles

Showing the 5 most recent journal articles. 98 available »

2016 Jun
Chepelev NL, Long AS, Bowers WJ, Gagné R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL. "Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene." Environmental and molecular mutagenesis. 2016 Jun; 57(5):350-63. Epub 2016 May 19.
2015 Jun
Evans EE, Jonason AS, Bussler H, Torno S, Veeraraghavan J, Reilly C, Doherty MA, Seils J, Winter LA, Mallow C, Kirk R, Howell A, Giralico S, Scrivens M, Klimatcheva K, Fisher TL, Bowers WJ, Paris M, Smith ES, Zauderer M. "Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies." Cancer immunology research. 2015 Jun; 3(6):689-701. Epub 2015 Jan 22.
2015 Apr
Southwell AL, Franciosi S, Villanueva EB, Xie Y, Winter LA, Veeraraghavan J, Jonason A, Felczak B, Zhang W, Kovalik V, Waltl S, Hall G, Pouladi MA, Smith ES, Bowers WJ, Zauderer M, Hayden MR. "Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease." Neurobiology of disease. 2015 Apr; 76:46-56. Epub 2015 Feb 03.
2015 Jan
Smith ES, Jonason A, Reilly C, Veeraraghavan J, Fisher T, Doherty M, Klimatcheva E, Mallow C, Cornelius C, Leonard JE, Marchi N, Janigro D, Argaw AT, Pham T, Seils J, Bussler H, Torno S, Kirk R, Howell A, Evans EE, Paris M, Bowers WJ, John G, Zauderer M. "SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease." Neurobiology of disease. 2015 Jan; 73:254-68. Epub 2014 Oct 18.
2014 Nov 5
Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ, Tieu K. "Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo." Nature communications. 2014 Nov 5; 5:5244. Epub 2014 Nov 05.

Current Appointments

Adjunct Associate Professor - Department of Microbiology and Immunology (SMD)


PhD | Microbiology | University of Rochester1995
MS | Microbiology | University of Rochester1992
BS | Biotechnology | Rochester Inst Technology1990

Post-Doctoral Training & Residency

Improvement of herpes simplex virus amplicon vectors for therapeutic gene delivery to the CNS 1998