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William J. Bowers, Ph.D.


Showing all 98 journal articles & 5 books available

Journal Articles

Chepelev NL, Long AS, Bowers WJ, Gagné R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL. "Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene." Environmental and molecular mutagenesis.. 2016 Jun 0; 57(5):350-63. Epub 2016 May 19.

Evans EE, Jonason AS, Bussler H, Torno S, Veeraraghavan J, Reilly C, Doherty MA, Seils J, Winter LA, Mallow C, Kirk R, Howell A, Giralico S, Scrivens M, Klimatcheva K, Fisher TL, Bowers WJ, Paris M, Smith ES, Zauderer M. "Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies." Cancer immunology research.. 2015 Jun 0; 3(6):689-701. Epub 2015 Jan 22.

Southwell AL, Franciosi S, Villanueva EB, Xie Y, Winter LA, Veeraraghavan J, Jonason A, Felczak B, Zhang W, Kovalik V, Waltl S, Hall G, Pouladi MA, Smith ES, Bowers WJ, Zauderer M, Hayden MR. "Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease." Neurobiology of disease.. 2015 Apr 0; 76:46-56. Epub 2015 Feb 03.

Smith ES, Jonason A, Reilly C, Veeraraghavan J, Fisher T, Doherty M, Klimatcheva E, Mallow C, Cornelius C, Leonard JE, Marchi N, Janigro D, Argaw AT, Pham T, Seils J, Bussler H, Torno S, Kirk R, Howell A, Evans EE, Paris M, Bowers WJ, John G, Zauderer M. "SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease." Neurobiology of disease.. 2015 Jan 0; 73:254-68. Epub 2014 Oct 18.

Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ, Tieu K. "Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo." Nature communications. 2014 Nov 5; 5:5244. Epub 2014 Nov 05.

Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ. "Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies." The American journal of pathology.. 2013 Jun 0; 182(6):2285-97. Epub 2013 Apr 06.

Montgomery SL, Bowers WJ. "Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012 Mar 0; 7(1):42-59. Epub 2011 Jul 05.

García-Alías G, Petrosyan HA, Schnell L, Horner PJ, Bowers WJ, Mendell LM, Fawcett JW, Arvanian VL. "Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2011 Dec 7; 31(49):17788-99.

de Silva S, Bowers WJ. "Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors." Current gene therapy.. 2011 Oct 0; 11(5):332-40.

Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Burrell SA, Wright TW, Bowers WJ. "Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-? suppressive therapeutic strategies in the brain." The American journal of pathology.. 2011 Oct 0; 179(4):2053-70. Epub 2011 Aug 09.

Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. "Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord." The European journal of neuroscience.. 2011 Oct 0; 34(8):1256-67. Epub 2011 Oct 13.

Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S. "Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier." Vaccine.. 2011 Sep 16; 29(40):7080-9. Epub 2011 Jul 27.

Bowers WJ, Breakefield XO, Sena-Esteves M. "Genetic therapy for the nervous system." Human molecular genetics.. 2011 Apr 15; 20(R1):R28-41. Epub 2011 Mar 23.

Desai MK, Guercio BJ, Narrow WC, Bowers WJ. "An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction." Glia.. 2011 Apr 0; 59(4):627-40. Epub 2011 Feb 03.

Azadniv M, Bowers WJ, Topham DJ, Crispe IN. "CD4+ T cell effects on CD8+ T cell location defined using bioluminescence." PloS one. 2011 Jan 20; 6(1):e16222. Epub 2011 Jan 20.

Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. "Trk retrograde signaling requires persistent, Pincher-directed endosomes." Proceedings of the National Academy of Sciences of the United States of America.. 2011 Jan 11; 108(2):852-7. Epub 2010 Dec 27.

Hunter JM, Bowers WJ, Maarouf CL, Mastrangelo MA, Daugs ID, Kokjohn TA, Kalback WM, Luehrs DC, Valla J, Beach TG, Roher AE. "Biochemical and morphological characterization of the A?PP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease." Journal of Alzheimer's disease : JAD.. 2011 27(2):361-76.

de Silva S, Mastrangelo MA, Lotta Jr LT, Burris CA, Izsvák Z, Ivics Z, Bowers WJ. "Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo." Human gene therapy.. 2010 Nov 0; 21(11):1603-13. Epub 2010 Oct 22.

de Silva S, Lotta Jr LT, Burris CA, Bowers WJ. "Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform." Human gene therapy.. 2010 Nov 0; 21(11):1615-22. Epub 2010 Oct 07.

Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ. "Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target." The American journal of pathology.. 2010 Sep 0; 177(3):1422-35. Epub 2010 Aug 09.

Lee BD, Shin JH, Vankampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. "Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease." Nature medicine.. 2010 Sep 0; 16(9):998-1000. Epub 2010 Aug 22.

Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. "Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice." Molecular therapy : the journal of the American Society of Gene Therapy.. 2010 Aug 0; 18(8):1471-81. Epub 2010 Jun 15.

Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. "An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies." Journal of neuroscience methods.. 2010 Jul 15; 190(2):171-9. Epub 2010 May 07.

Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. "Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010 Jul 14; 30(28):9567-77.

Park KM, Bowers WJ. "Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction." Cellular signalling.. 2010 Jul 0; 22(7):977-83. Epub 2010 Jan 21.

Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. "GTPase activity plays a key role in the pathobiology of LRRK2." PLoS genetics.. 2010 Apr 8; 6(4):e1000902. Epub 2010 Apr 08.

de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. "Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform." Gene therapy.. 2010 Mar 0; 17(3):424-31. Epub 2009 Oct 29.

Park KM, Yule DI, Bowers WJ. "Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons." Cellular signalling.. 2010 Mar 0; 22(3):519-26.

Fong S, Chan MK, Fong A, Bowers WJ, Kelly KJ. "Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells." Cancer gene therapy.. 2010 Feb 0; 17(2):80-5. Epub 2009 Oct 16.

Olson DA, Driver RG, Bowers WJ. "A Gas Pressure Scale Based on Primary Standard Piston Gauges." Journal of research of the National Institute of Standards and Technology.. 2010 115(6):393-412. Epub 2010 Dec 01.

de Silva S, Bowers WJ. "Herpes Virus Amplicon Vectors." Viruses. 2009 Dec 1; 1(3):594-629.

Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. "Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease." Molecular therapy : the journal of the American Society of Gene Therapy.. 2009 Dec 0; 17(12):2031-40. Epub 2009 Jul 28.

Mastrangelo MA, Sudol KL, Narrow WC, Bowers WJ. "Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice." The American journal of pathology.. 2009 Nov 0; 175(5):2076-88. Epub 2009 Oct 01.

Park KM, Yule DI, Bowers WJ. "Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter." The Journal of biological chemistry.. 2009 Oct 2; 284(40):27557-66. Epub 2009 Aug 07.

Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. "Real-time MR imaging of adeno-associated viral vector delivery to the primate brain." NeuroImage.. 2009 Aug 0; 47 Suppl 2:T27-35. Epub 2008 Nov 27.

Federoff HJ, Chiu YG, Bowers WJ, Lim ST, Ryan DA. "Effects of herpes simplex virus amplicon transduction on murine dendritic cells." Human gene therapy.. 2009 May 0; 20(5):442-52.

Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response." Blood.. 2009 Apr 2; 113(14):3264-75. Epub 2008 Oct 24.

Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ. "Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology." Glia.. 2009 Jan 1; 57(1):54-65.

Bancos S, Cao Q, Bowers WJ, Crispe IN. "Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4." Cellular immunology.. 2009 257(1-2):44-54.

Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. "Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice." The American journal of pathology.. 2008 Dec 0; 173(6):1768-82. Epub 2008 Oct 30.

Park KM, Yule DI, Bowers WJ. "Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor." The Journal of biological chemistry.. 2008 Nov 28; 283(48):33069-79. Epub 2008 Oct 06.

Mastrangelo MA, Bowers WJ. "Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice." BMC neuroscience. 2008 Aug 12; 9:81. Epub 2008 Aug 12.

Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. "Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction." Cancer immunology, immunotherapy : CII.. 2008 May 0; 57(5):663-75. Epub 2007 Oct 19.

Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. "Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4." Molecular therapy : the journal of the American Society of Gene Therapy.. 2008 May 0; 16(5):845-53. Epub 2008 Mar 11.

Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. "Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0." The journal of gene medicine.. 2008 Feb 0; 10(2):152-64.

Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. "HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime." Vaccine.. 2007 Oct 16; 25(42):7410-21. Epub 2007 Aug 30.

Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. "Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo." Cancer research.. 2007 Oct 15; 67(20):10027-37.

Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. "Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition." Molecular therapy : the journal of the American Society of Gene Therapy.. 2007 Oct 0; 15(10):1848-55. Epub 2007 Jul 24.

Azadniv M, Dugger K, Bowers WJ, Weaver C, Crispe IN. "Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter." International immunology.. 2007 Oct 0; 19(10):1165-73. Epub 2007 Aug 14.

Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. "Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival." Brain research.. 2007 Feb 23; 1134(1):33-44. Epub 2006 Dec 28.

Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. "Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag." Vaccine.. 2007 Feb 19; 25(9):1634-46. Epub 2006 Nov 15.

Santos, K.; Sanfilippo, C.M.; Narrow, W.C.; Casey, A.E.; McDermott, M.; Federoff, H.J.; Bowers, W.J.; Dewhurst, S. "Infectivity of Herpes Simplex Virus Type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging". J Virol Meth. 2007; 145: 37-46.

Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. "Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity." The journal of gene medicine.. 2006 Nov 0; 8(11):1320-8.

Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. "HSV amplicons: neuro applications." Current gene therapy.. 2006 Jun 0; 6(3):337-50.

Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. "Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector." Molecular therapy : the journal of the American Society of Gene Therapy.. 2006 Mar 0; 13(3):580-8. Epub 2006 Jan 18.

Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. "Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat." Experimental neurology.. 2006 Feb 0; 197(2):347-52. Epub 2005 Nov 11.

Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. "Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma." Annals of surgical oncology.. 2005 Dec 0; 12(12):1025-36. Epub 2005 Oct 25.

Federoff HJ, Bowers WJ. "Immune shaping and the development of Alzheimer's disease vaccines." Science of aging knowledge environment : SAGE KE. 2005 Nov 16; 2005(46):pe35. Epub 2005 Nov 16.

Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. "Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice." Journal of neuroinflammation. 2005 Oct 18; 2:23. Epub 2005 Oct 18.

Corso TD, Torres G, Goulah C, Roy I, Gambino AS, Nayda J, Buckley T, Stachowiak EK, Bergey EJ, Pudavar H, Dutta P, Bloom DC, Bowers WJ, Stachowiak MK. "Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods." Folia morphologica.. 2005 Aug 0; 64(3):130-44.

Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. "HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses." Neurobiology of aging.. 2005 Apr 0; 26(4):393-407.

Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. "Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge." Journal of virology.. 2005 Feb 0; 79(4):2124-32.

Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. "Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2004 Dec 1; 24(48):10963-73.

Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. "Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2004 Nov 0; 8(7):812-22; discussion 822-3.

Arvanian, V.L.; Bowers, W.J.; Petruska, J.C.; Motin, V.; Manuzon, H.; Narrow, W.C.; Federoff, H.J.; Mendell, L.M. "Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons." J. Neurophys. 2004; 92: 2394-2404.

Kyrkanides S, Miller JH, Bowers WJ, Federoff HJ. "Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system." Molecular therapy : the journal of the American Society of Gene Therapy.. 2003 Nov 0; 8(5):790-5.

Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. "HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury." Experimental neurology.. 2003 Sep 0; 183(1):47-55.

Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. "p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 Aug 13; 23(19):7385-94.

Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. "Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming." Vaccine.. 2003 Jun 2; 21(19-20):2288-97.

Bowers WJ, Olschowka JA, Federoff HJ. "Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy." Gene therapy.. 2003 Jun 0; 10(11):941-5.

Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. "Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing." Nature medicine.. 2003 Feb 0; 9(2):231-5. Epub 2003 Jan 21.

Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. "Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS." Molecular therapy : the journal of the American Society of Gene Therapy.. 2003 Feb 0; 7(2):218-27.

Wang SW, Mu X, Bowers WJ, Klein WH. "Retinal ganglion cell differentiation in cultured mouse retinal explants." Methods : a companion to Methods in enzymology.. 2002 Dec 0; 28(4):448-56.

Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. "Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity." Cancer research.. 2002 Nov 15; 62(22):6545-51.

Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. "HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 Oct 0; 6(4):455-63.

Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. "Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor." Science.. 2002 Jul 12; 297(5579):259-63.

Mankodi A, Takahashi MP, Jiang H, Beck CL, Bowers WJ, Moxley RT, Cannon SC, Thornton CA. "Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy." Molecular cell.. 2002 Jul 0; 10(1):35-44.

Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. "Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses." Journal of virology.. 2002 Jun 0; 76(11):5565-80.

Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. "Reporter gene transfer induces apoptosis in primary cortical neurons." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 Jun 0; 5(6):723-30.

Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. "Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 Mar 0; 5(3):300-6.

Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. "Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth." Development.. 2002 Jan 0; 129(2):467-77.

Bowers, W.J.; Chen, X.; Guo, H.; Frisina, D.R.; Federoff, H.J.; Frisina, R.D.;. "Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea". Mol Ther. 2002; 6(1): Ganglion/drug effects/*physiopathology.

Bowers WJ, Federoff HJ. "Amyloid immunotherapy-engendered CNS inflammation." Neurobiology of aging.. 2002 23(5):675-6; discussion 683-4.

Maguire-Zeiss KA, Bowers WJ, Federoff HJ. "Somatic mosaic approaches and the aging brain." Neurobiology of aging.. 2002 23(5):977-84.

Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. "Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice." Human gene therapy.. 2001 Oct 10; 12(15):1867-79.

Maguire-Zeiss KA, Bowers WJ, Federoff HJ. "HSV vector-mediated gene delivery to the central nervous system." Current opinion in molecular therapeutics. 2001 Oct 0; 3(5):482-90.

Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. "Regulation of neuronal traits by a novel transcriptional complex." Neuron.. 2001 Aug 16; 31(3):353-65.

Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. "Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia." Blood.. 2001 Jul 15; 98(2):287-95.

Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. "HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage." Molecular therapy : the journal of the American Society of Gene Therapy.. 2001 Jun 0; 3(6):958-63.

Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins." Nature.. 2001 Mar 1; 410(6824):89-93.

Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. "Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers." Gene therapy.. 2001 Jan 0; 8(2):111-20.

Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. "Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus." Human gene therapy.. 2000 Nov 20; 11(17):2341-52.

Bowers WJ, Howard DF, Federoff HJ. "Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration." Molecular therapy : the journal of the American Society of Gene Therapy.. 2000 Mar 0; 1(3):294-9.

Baglia LA, Bowers WJ, Ruddell A. "The avian C/EBPgamma gene encodes a highly conserved leucine zipper transcription factor." Gene.. 1997 May 6; 190(2):297-302.

Bowers WJ, Howard DF, Federoff HJ. "Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease." Experimental neurology.. 1997 Mar 0; 144(1):58-68.

Bowers WJ, Baglia LA, Ruddel A. "Regulation of avian leukosis virus long terminal repeat-enhanced transcription by C/EBP-Rel interactions." Journal of virology.. 1996 May 0; 70(5):3051-9.

Bowers WJ, Petrosino JF, Smith CD, Ruddell A. "Transcriptional regulation of ALV bursal lymphomagenesis." Leukemia.. 1994 Apr 0; 8 Suppl 1:S211-3.

Bowers WJ, Ruddell A. "a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer." Journal of virology.. 1992 Nov 0; 66(11):6578-86.

Books & Chapters

Chapter Title: Application to gene therapy and vaccination.
Book Title: Neuroimmune Pharmacology
Author List: Bowers, W.J.; Janelsins, M.C.; Federoff, H.J.
Edited By: Ikezu, T.; Gendelman, H.
Published By: Springer2007 in New York, NY

Chapter Title: Immunotherapeutic approaches for Alzheimer's disease
Book Title: Gene Therapy for Neurological Disorders
Author List: Bowers, W.J.; Federoff, H.J.
Edited By: Lowenstein, P.; Castro, M.
Published By: Taylor and Francis2006 in New York, NY

Chapter Title: Herpes Simplex Virus Type-1-derived Amplicon Vectors
Book Title: Gene Transfer: Delivery and Expression of DNA and RNA
Author List: Bowers, W.J.; Federoff, H.J.
Edited By: Friedmann, T.; Rossi, J.
Published By: Cold Spring Harbor Laboratory Press2006 in Cold Spring Harbor, NY

Chapter Title: Gene therapy for neurological diseases.
Book Title: Gene Therapy: Therapeutic Mechanisms and Strategies
Author List: Bowers, W.J.; Federoff, H.J.
Edited By: Templeton, N.S.
Published By: Marcel Dekker2004 in New York, NY

Chapter Title: HSV amplicon vectors in neuronal apoptosis studies.
Book Title: Neuromethods
Author List: Maguire-Zeiss, K.A.; Bowers, W.J.; Federoff, H.J.
Edited By: LeBlanc, A.
Published By: Humana Press2002 in Totowa, NJ