Mark P. Sowden, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-3014

Fax: (585) 276-2272

Locations

Aab Cardiovascular Research Institute
601 Elmwood Avenue
Rochester, NY

Biography

Research

Dr. Sowden received the University of Rochester Deans Institutional Award in 2002-04 to study the role of activation induced deaminase as an RNA editing enzyme in human B-cell function. Since then, he has received support from the UR Environmental Health Sciences Center and the Philip Morris External Research Program for related studies of smoking-associated carcinogenesis and teh APOBEC family of deaminases.

He is currently working with Dr. Peter Sims and Dr. Therese Wiedmer in studies of phospholipid scramblases.

Credentials

Faculty Appointments

Research Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary

Education

1987
BS | University of Warwick - Non-Medical School
Microbiology

1990
PhD | University of Oxford - Non-Medical School
Arts & Sciences

1992
Post-Doc | University of Rochester Medical Center
HPV Biology

1995
Post-Doc | University of Rochester Medical Center
RNA Editing

Publications

Journal Articles

3/2007
Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. "Functional characterization of APOBEC-1 complementation factor phosphorylation sites." Biochimica et biophysica acta.. 2007 Mar 0; 1773(3):408-18. Epub 2006 Dec 08.

11/10/2006
Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. "APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic." Biochemical and biophysical research communications.. 2006 Nov 10; 350(1):214-9. Epub 2006 Sep 18.

7/1/2006
Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A. "Structural phylogenetic analysis of activation-induced deaminase function." The Journal of immunology : official journal of the American Association of Immunologists.. 2006 Jul 1; 177(1):355-61.

Books & Chapters

2005
Chapter Title: In "Topics in Current Genetics"
Book Title: Mammalian C to U Editing
Author List: Smith, H.C.; Wedeking, J.E.; Xie, K. and Sowden, M.P.
Edited By: Grosjean, H:Editor
Published By: Springer-Verlag2005

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