Mark P. Sowden, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-3014

Fax: (585) 276-2272

Locations

Aab Cardiovascular Research Institute
601 Elmwood Avenue
Rochester, NY 14642

Faculty Appointments

Research Associate Professor - Department of Medicine , Aab Cardiovascular Research Institute (SMD) - Primary

Biography

Research

Dr. Sowden received the University of Rochester Deans Institutional Award in 2002-04 to study the role of activation induced deaminase as an RNA editing enzyme in human B-cell function. Since then, he has received support from the UR Environmental Health Sciences Center and the Philip Morris External Research Program for related studies of smoking-associated carcinogenesis and teh APOBEC family of deaminases.

He is currently working with Dr. Peter Sims and Dr. Therese Wiedmer in studies of phospholipid scramblases.

Credentials

Education

1987
BS | University of Warwick - Non-Medical School
Microbiology

1990
PhD | University of Oxford - Non-Medical School
Arts & Sciences

1992
Post-Doc | University of Rochester Medical Center
HPV Biology

1995
Post-Doc | University of Rochester Medical Center
RNA Editing

Publications

Journal Articles

3/2007
Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. "Functional characterization of APOBEC-1 complementation factor phosphorylation sites." Biochimica et biophysica acta.. 2007 Mar 0; 1773(3):408-18. Epub 2006 Dec 08.

11/10/2006
Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. "APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic." Biochemical and biophysical research communications.. 2006 Nov 10; 350(1):214-9. Epub 2006 Sep 18.

7/1/2006
Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A. "Structural phylogenetic analysis of activation-induced deaminase function." The Journal of immunology : official journal of the American Association of Immunologists.. 2006 Jul 1; 177(1):355-61.

Books & Chapters

2005
Chapter Title: In "Topics in Current Genetics"
Book Title: Mammalian C to U Editing
Author List: Smith, H.C.; Wedeking, J.E.; Xie, K. and Sowden, M.P.
Edited By: Grosjean, H:Editor
Published By: Springer-Verlag2005

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