Mark P. Sowden, Ph.D.

Mark P. Sowden, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
601 Elmwood Avenue
Rochester, NY 14642

Office: (585) 276-3014
Fax: (585) 276-2272

Journal Articles

Showing all 35 journal articles available.

2007 Mar
Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. "Functional characterization of APOBEC-1 complementation factor phosphorylation sites." Biochimica et biophysica acta. 2007 Mar; 1773(3):408-18. Epub 2006 Dec 08.
2006 Nov 10
Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. "APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic." Biochemical and biophysical research communications. 2006 Nov 10; 350(1):214-9. Epub 2006 Sep 18.
2006 Jul 1
Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A. "Structural phylogenetic analysis of activation-induced deaminase function." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Jul 1; 177(1):355-61.
2006 Apr 15
Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE. "Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase." The Biochemical journal. 2006 Apr 15; 395(2):363-71.
Lehmann DM, Galloway CA, Sowden MP, Smith HC. "Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor." Nucleic acids research. 2006 34(11):3299-308. Epub 2006 Jul 04.
2004 Jun
Smith HC, Bottaro A, Sowden MP, Wedekind JE. "Activation induced deaminase: the importance of being specific." Trends in genetics : TIG. 2004 Jun; 20(6):224-7.
2004 May 25
Xie K, Sowden MP, Dance GS, Torelli AT, Smith HC, Wedekind JE. "The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1." Proceedings of the National Academy of Sciences of the United States of America. 2004 May 25; 101(21):8114-9. Epub 2004 May 17.
2004 Jan 2
Sowden MP, Lehmann DM, Lin X, Smith CO, Smith HC. "Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing." The Journal of biological chemistry. 2004 Jan 2; 279(1):197-206. Epub 2003 Oct 21.
2003 Jul 23
Reeder JE, Sowden MP, Messing EM, Klover P, Villa-Moruzzi E, Ludlow JW. "Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line." Cancer cell international. 2003 Jul 23; 3(1):12. Epub 2003 Jul 23.
2003 Apr
Wedekind JE, Dance GS, Sowden MP, Smith HC. "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." Trends in genetics : TIG. 2003 Apr; 19(4):207-16.
2003 Mar
Galloway CA, Sowden MP, Smith HC. "Increasing the yield of soluble recombinant protein expressed in E. coli by induction during late log phase." BioTechniques. 2003 Mar; 34(3):524-6, 528, 530.
2002 Apr 12
Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC. "Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing." The Journal of biological chemistry. 2002 Apr 12; 277(15):12703-9. Epub 2002 Jan 28.
2002 Mar 1
Sowden MP, Ballatori N, Jensen KL, Reed LH, Smith HC. "The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors." Journal of cell science. 2002 Mar 1; 115(Pt 5):1027-39.
2001 Dec 21
Giangreco A, Sowden MP, Mikityansky I, Smith HC. "Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis." Biochemical and biophysical research communications. 2001 Dec 21; 289(5):1162-7.
2001 Jul 15
Yang Y, Sowden MP, Yang Y, Smith HC. "Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA." Experimental cell research. 2001 Jul 15; 267(2):153-64.
Sowden, M.P. and Smith, H.C. "Commitment of Apolipoprotein B PremRNA to the Splicing Pathway Regulates C to U Editing Site Utilization". Biochem Journal. 2001; 359(3): 697-705.
2000 Jan 15
Dance GS, Sowden MP, Yang Y, Smith HC. "APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast." Nucleic acids research. 2000 Jan 15; 28(2):424-9.
Yang, Y.; Sowden, M.P. and Smith, H.C. "Induction of cytidine to uridine Editing on cytoplasmic Apolipoprotein B mRNA by overexpressing APOBEC-1". J. Biol. Chemistry. 2000; 275(30): 22663-22669.
1999 Oct 10
Siddiqui JF, Van Mater D, Sowden MP, Smith HC. "Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity." Experimental cell research. 1999 Oct 10; 252(1):154-64.
1999 Aug 1
Sowden MP, Collins HL, Smith HC, Garrow TA, Sparks JD, Sparks CE. "Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase." The Biochemical journal. 1999 Aug 1; 341 ( Pt 3):639-45.
Sowden, M.P. and Smith, H.C. "RNA Editing". In Encyclopedia of Life Sciences. 1999; .
1998 Nov 18
Van Mater D, Sowden MP, Cianci J, Sparks JD, Sparks CE, Ballatori N, Smith HC. "Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells." Biochemical and biophysical research communications. 1998 Nov 18; 252(2):334-9.
1998 Nov
Sparks JD, Phung TL, Bolognino M, Cianci J, Khurana R, Peterson RG, Sowden MP, Corsetti JP, Sparks CE. "Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: hyperinsulinemic versus insulinopenic hyperglycemia." Metabolism: clinical and experimental. 1998 Nov; 47(11):1315-24.
1998 Apr 1
Sowden MP, Eagleton MJ, Smith HC. "Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing." Nucleic acids research. 1998 Apr 1; 26(7):1644-52.
1998 Feb 15
Stewart J, Kozlowski P, Sowden M, Messing E, Smith HC. "A quantitative assay for assessing allelic proportions by iterative gap ligation." Nucleic acids research. 1998 Feb 15; 26(4):961-6.
1997 Jul 12
Sparks JD, Collins HL, Sabio I, Sowden MP, Smith HC, Cianci J, Sparks CE. "Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells." Biochimica et biophysica acta. 1997 Jul 12; 1347(1):51-61.
Collins, H.L.; Sowden, M.P.; Smith, H.C.; Sparks, J.D. & Sparks, C.E. "ApoB Secreation and mRNA levels are increased in McArdle cells expressing a novel protein factor". Circulation. 1997; 96(8): 3041. Suppl S.
1996 Oct
Smith HC, Sowden MP. "Base-modification mRNA editing through deamination--the good, the bad and the unregulated." Trends in genetics : TIG. 1996 Oct; 12(10):418-24.
1996 May
Marsh JB, Diffenderfer MR, Fisher EA, Sowden M, Dong M, Paterniti JR, Burkey BF. "Effect of experimental nephrosis on hepatic lipoprotein secretion and urinary lipoprotein excretion in rats expressing the human apolipoprotein A-I gene." Journal of lipid research. 1996 May; 37(5):1113-24.
1996 Mar
Sowden M, Hamm JK, Spinelli S, Smith HC. "Determinants involved in regulating the proportion of edited apolipoprotein B RNAs." RNA. 1996 Mar; 2(3):274-88.
1996 Feb 9
Sowden M, Hamm JK, Smith HC. "Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing." The Journal of biological chemistry. 1996 Feb 9; 271(6):3011-7.
1996 Feb 1
Skuse GR, Cappione AJ, Sowden M, Metheny LJ, Smith HC. "The neurofibromatosis type I messenger RNA undergoes base-modification RNA editing." Nucleic acids research. 1996 Feb 1; 24(3):478-85.
Phung, T.L.; Sowden, M.; Sparks, J.D.; Sparks, C.E. & Smith, H.C. "Regulation of Hepatic ApoB RNA Editing in the Genetically Obese Sucker Rat". Metabolism. 1996; 45(9): 1-4.
1989 Apr 25
Sowden M, Harrison S, Ashfield R, Kingsman AJ, Kingsman SM. "Multiple cooperative interactions constrain BPV-1 E2 dependent activation of transcription." Nucleic acids research. 1989 Apr 25; 17(8):2959-72.
1989 Mar 25
Stanway CA, Sowden MP, Wilson LE, Kingsman AJ, Kingsman SM. "Efficient activation of transcription in yeast by the BPV1 E2 protein." Nucleic acids research. 1989 Mar 25; 17(6):2187-96.


Smith, H.C.; Wedeking, J.E.; Xie, K. and Sowden, M.P.. "In "Topics in Current Genetics"". Mammalian C to U Editing. Grosjean, H:Editor. : Springer-Verlag, 2005. 365-400