Xinping Zhang, B.Med., Ph.D.

Xinping Zhang, B.Med., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Office: (585) 275-7928
Lab: (585) 273-4255

Journal Articles

Showing all 48 journal articles available.

2009 Oct
Tsutsumi, R; Xie, C; Wei, X; Zhang, X; Flick, LM; Schwarz, EM; O'Keefe, RJ. "PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis". J Bone Miner Res. 2009; 24(10): 1753-62.
Naik A; Xie, C; Kingsley, P; Zuscik, MJ; Schwarz, EM; Awad, H; Guldberg, R; Drissi, H; Puzas, E; Boyce, B; Zhang, X; O'Keefe, RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing". Journal of Bone & Mineral Research. 2009; 24(2): 251-64.
Xie, C; Liang, B; Xue, M; Lin, ASP; Loiselle, A; Schwarz, EM; Guldberg, RE; O'Keefe, RJ; Zhang, X. "Rescue of Impaired Fracture Healing in Cox-2-/- mice via Activation of Prostaglandin E2 Receptor Subtype 4". The American Journal of Pathology. 2009; 175(2): 772-85.
Clark, CA; Li, TF; Kim, KO; Drissi, H; Zuscik, MJ; Zhang, X; O'Keefe, RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation". J. Orthop. Res. 2009; 27(6): 785-92.
Xie, C., Liang, B., Xue, M., Lin, ASP., Loiselle, A. Schwarz, EM, Guildberg, RE., O'Keefe, RJ, Zhang, X. "Rescue of impaired fracture healing in COX-2 mice via activation of prostaglandin E2 receptor subtype 4." The American Journal of Pathology. 2009; 175(2): 772-85.
2008 Feb
Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. "Regulation of chondrogenesis and chondrocyte differentiation by stress." The Journal of clinical investigation. 2008 Feb; 118(2):429-38.
2008 Feb
Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. "Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation." The Journal of bone and joint surgery. American volume. 2008 Feb; 90 Suppl 1:9-13.
Zhang, X., Awad, A.H., O'Keefe, R.J., Guldberg, R.J., Schwarz, E.M. "Periosteum is essential for the initiation of structural bone graft healing: implication for tissue engineering." Clinical Orthopaedics and Related Research. 2008; .
Zhang, X; Awad, HA; O'Keefe, RJ; Guldberg, RE, Schwarz, EM;. "Perspective: Engineering Periosteum for Structural Bone Graft Healing". Clinical Orthopaedics & Related Research. 2008; 466(8): 1777-87.
Xie, C; Xue, M; Lin, A; Schwarz, E; Guldberg, R; O'Keefe, R, Zhang, X. "COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing". Bone. 2008; 43(6): 1075-83.
Yazici, C; Yanoso, L; Xie, C; Reynolds, DG; Samulski, RJ; Samulski, J; Yannariello-Brown, J; Gertzmann, AA; Zhang, X; Awad, HA; Schwarz, EM. "The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings". Biomaterials. 2008; 29(28): 3882-7.
2007 Sep 20
Zhang X, Sun B. "Organic crystal fibers aligned into oriented bundles with polarized emission." The journal of physical chemistry. B. 2007 Sep 20; 111(37):10881-5. Epub 2007 Aug 28.
2007 Aug
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. "Recent advances in gene delivery for structural bone allografts." Tissue engineering. 2007 Aug; 13(8):1973-85.
2007 Apr 6
Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. "Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2." The Journal of biological chemistry. 2007 Apr 6; 282(14):10742-8. Epub 2007 Jan 10.
2007 Mar
Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. "Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering." Tissue engineering. 2007 Mar; 13(3):435-45.
2007 Jan
Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D. "Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase." Genesis : the journal of genetics and development. 2007 Jan; 45(1):44-50.
Reynolds, D.G., Hock, C., Shaikh, S., Jacobson, J., Zhang, X., Rubery, P.T., Beck, C., O'Keefe, R.J., Lerner, A., Schwarz, E.M., Awad H. "Radiographic Prediction of Biomechanical Strength in Structural Bone Grafts." J. Biomech. 40(14):3178-86. 2007; : 3178-86.
Xie, C., Xue, M., Naik, A., Lin, A., Schwarz, E., Guldberg, R., O'Keefe R, J., and Zhang, X. "Cox-2 deficient bone healing environment impairs initiation of periosteum dependent endochondral bone repair. (under review in JBMR)". JBMR (under review). 2007; .
Ghen, M; Lichtler, AC; Sheu, TJ; Xie, C; Zhang X; O'Keefe, RJ; Chen D. "Targeted Gene Delivery for Femoral Allografts: A Novel Acellular Tissue Engineering Approach". Genesis. 2007; 45(1): 44-50.
Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. "Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts." Journal of biomechanics. 2007 40(14):3178-86. Epub 2007 May 23.
Bärnighausen T, Liu Y, Zhang X, Sauerborn R. "Willingness to pay for social health insurance among informal sector workers in Wuhan, China: a contingent valuation study." BMC health services research. 2007 7:114. Epub 2007 Jul 20.
2006 Apr
Zhang X, Sun B, Friend RH, Guo H, Nau D, Giessen H. "Metallic photonic crystals based on solution-processible gold nanoparticles." Nano letters. 2006 Apr; 6(4):651-5.
2006 Apr
O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. "COX-2 has a critical role during incorporation of structural bone allografts." Annals of the New York Academy of Sciences. 2006 Apr; 1068:532-42.
2006 Mar
Murugan R, Ramakrishna S. "Nano-featured scaffolds for tissue engineering: a review of spinning methodologies." Tissue engineering. 2006 Mar; 12(3):435-47.
Robertson, G., Xie, C., Chen, D., Awad, H., Schwarz, E.M., O'Keefe, R.J., Guldberg R.E., Zhang, X. "Alteration of femoral bone morphology and density in cox-2-/- mice." Bone Oct. 2006; : 767-72.
2005 Aug
Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. "Biological effects of rAAV-caAlk2 coating on structural allograft healing." Molecular therapy : the journal of the American Society of Gene Therapy. 2005 Aug; 12(2):212-8.
2005 Jul
Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. "Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2005 Jul; 20(7):1136-48. Epub 2005 Feb 14.
2005 Jun
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. "Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency." Environmental health perspectives. 2005 Jun; 113(6):749-55.
2005 Mar 18
Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ. "Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation." Biochemical and biophysical research communications. 2005 Mar 18; 328(3):764-76.
2005 Mar
Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. "Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy." Nature medicine. 2005 Mar; 11(3):291-7. Epub 2005 Feb 13.
Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. "Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2005 20(12):2124-37. Epub 2005 Aug 08.
Zhang X, Naik A, Xie C, Reynolds D, Palmer J, Lin A, Awad H, Guldberg R, Schwarz E, O'Keefe R. "Periosteal stem cells are essential for bone revitalization and repair." Journal of musculoskeletal & neuronal interactions. 2005 5(4):360-2.
Gu X, Feng Y, Shi C, Li M, Fu Z, Zhang X. "Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats." Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2005 25(6):632-5.
2004 Oct 15
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. "PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling." Experimental cell research. 2004 Oct 15; 300(1):159-69.
2004 May
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. "Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation." Bone. 2004 May; 34(5):809-17.
Bukata, S., Gelinas, J., Wei, X., Rosier, R. N., Puzas, J. E., Zhang, X., Schwarz, E. M., Song, X. R., Griswold, D. E., O'Keefe, R. J. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a COX-2 dependent pathway. ." J. of Orthopaedic Research. 2004; : 6-12.
Tiyapatanaputi, P., Rubery, P. T, Carmouche, J, Schwarz, E. M., O'Keefe, R. J. and Zhang, X. "A Novel Murine Segmental Femoral Graft Model. J. of Othopaedic Research." J. of Othopaedic Research. 2004; : 1254-60.
Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X. "Functional integration of tissue-engineered bone constructs." Journal of musculoskeletal & neuronal interactions. 2004 4(4):399-400.
2003 Sep
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. "Smad6 is induced by BMP-2 and modulates chondrocyte differentiation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2003 Sep; 21(5):908-13.
Flick, L. M., Weaver, J. M., Ulrich-Vinther, M., Abuzzahab, F., Zhang, X., Dougal, W.C., Anderson, D., O'Keefe, R. J., Schwarz, E. M. "Effects of receptor activator of NFkB (RANK) signaling blockade on fracture healing." J. of Orthopaedic Research. 2003; : 676-84.
Zhang, X., Schwarz, E. M., Young, D. A., R., Puzas, J. E., Rosier, R. N., O'Keefe, R.J. "COX-2 Regulates Mesenchymal Cell Differentiation into Osteoblast Lineage and is Critically Involved in Bone Repair. Journal of Clinical Investigation". 2002; : 1405-15.
Zhang, X., Morham, S. G., Langenback, R., Young, D. A., Xing, L., Boyce, B. F., Puzas, J. E., Rosier, R. N., O'Keefe, R. J., and Schwarz, E. M. "Evidence for a 4 Direct Role of COX-2 in Implant Wear Debris Induced Osteolysis". J. Bone. Min. Res. 2001; 16 (4): 660-669.
Zhang, X., Zhang, Y, Schwarz, E., O'Keefe, R. J. "The role of COX-2 in bone repair." Current opinion in Orthopaedics. 2001; : 397-402,.
2000 Feb 1
Zhang X, Morham SG, Langenbach R, Baggs RB, Young DA. "Lack of cyclooxygenase-2 inhibits growth of teratocarcinomas in mice." Experimental cell research. 2000 Feb 1; 254(2):232-40.
1999 Aug 16
Zhang X, Morham SG, Langenbach R, Young DA. "Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts." The Journal of experimental medicine. 1999 Aug 16; 190(4):451-59.
Mungo, D. V., Zhang, X., O'Keefe, R.J., Rosier, R.N., Puzas, J.E., Schwarz, E.M. "2001. COX-1 and COX-2 expression in osteoid osteomas. J. Ortho. Res.,". 20(1): 159-62.
Puzas, J.E., O'Keefe, R.J., Schwarz, E.M., and Zhang, X. "2003. Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition." J Musculoskelet Neuronal Interact. : 308-312; Discussion 320-301.
Clark, CA, Li, RF., Kim, KO., Drissi, H., Zuscik, MJ., Zhang, X., O'Keefe, RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation." Journal of Orthopaedic Research. 6: 785-92.