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Michael O'Banion, M.D., Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5185

Fax: (585) 756-5334

Research Labs

Biography

RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease. Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contribute to the pathogenesis of Alzheimer's and other brain diseases. Based on our pioneering work in the area of cyclooxygenase-2 and inflammation, we initiated a research program that focuses on understanding the role of neuroinflammation in Alzheimer's and other neurodegenerative diseases. Studies conducted in the laboratory with human brain tissue, neuronal cell culture models and mouse models of acute injury and neurodegeneration have pointed to a prominent role for specific proinflammatory cytokines and bioactive prostaglandins in promoting neuroinflammation. Interestingly, our current work in Alzheimer's disease has revealed a potential protective role for neuroinflammation and has led to a focus on the influence of glial expressed cytokines and infiltrating peripheral cells on brain pathology, utilizing genetic and pharmacological approaches in a variety of mouse models. In complementary work, we also have active preclinical projects in the area of brain radiation injury, a critical problem for individuals receiving radiotherapy for brain tumors or bone marrow transplantation. The main goal is to understand the role of neuroinflammation and oxidative stress in promoting injury and to determine whether therapeutic interventions targeting these processes can alleviate late radiation effects, including cognitive changes

Professional Background

EDUCATION: 1976 – 1980 University of Illinois, College of Liberal Arts and Sciences - B.S. with honors in Biology (summa cum laude). Research training with Dr. Sue Carter-Porges, Department of Neural and Behavioral Biology. 1980 – 1987 University of Illinois, College of Liberal Arts and Sciences - M.S., Ph.D. in Microbiology. 1980 – 1987 University of Illinois, School of Medicine, Urbana, Illinois - M.D. with honors. 1987 – 1990 Postdoctoral Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry. FACULTY APPOINTMENTS: 1990 – 1991 Instructor and Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry 1991 – 1997 Assistant Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry 1997 – 2000 Associate Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry 2000 – Present Associate Professor (Tenured in 2002), Departments of Neurobiology and Anatomy and of Neurology, University of Rochester School of Medicine & Dentistry HONORS, AWARDS AND FELLOWSHIPS: 1977 – 1980 Edmund J. James Scholar 1980 Phi Kappa Phi (Honorary Society) 1980 B.S. with honors (summa cum laude); Bronze Tablet Recipient 1980 University of Illinois Life Sciences Predoctoral Fellowship 1982 Excellence in Undergraduate Teaching Award 1984 Otto Saphir Memorial Award in Pathology 1984 Alpha Omega Alpha (Honorary Medical Society) 1986 University of Illinois College of Medicine Predoctoral Fellowship 1987 M.D. with honors; Valedictorian Address, Medical School Commencement 1987 Lange Book Award 1988 Proficiency in Pediatrics Book Award 1987 – 1989 NIH Postdoctoral Training Fellow in Endocrinology and Metabolism, University of Rochester 1988 – 1991 Wilmot Cancer Research Postdoctoral Fellowship, University of Rochester 1990 – 1991 New York State Health Research Council Postdoctoral Fellowship for Diabetes Research 1996 – 1999 George W. Corner Dean's Teaching Scholar 1998 Graduate Student Society Faculty Teaching Award

Research

RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease. Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contribute to the pathogenesis of Alzheimer's and other brain diseases. Based on our pioneering work in the area of cyclooxygenase-2 and inflammation, we initiated a research program that focuses on understanding the role of neuroinflammation in Alzheimer's and other neurodegenerative diseases. Studies conducted in the laboratory with human brain tissue, neuronal cell culture models and mouse models of acute injury and neurodegeneration have pointed to a prominent role for specific proinflammatory cytokines and bioactive prostaglandins in promoting neuroinflammation. Interestingly, our current work in Alzheimer's disease has revealed a potential protective role for neuroinflammation and has led to a focus on the influence of glial expressed cytokines and infiltrating peripheral cells on brain pathology, utilizing genetic and pharmacological approaches in a variety of mouse models. In complementary work, we also have active preclinical projects in the area of brain radiation injury, a critical problem for individuals receiving radiotherapy for brain tumors or bone marrow transplantation. The main goal is to understand the role of neuroinflammation and oxidative stress in promoting injury and to determine whether therapeutic interventions targeting these processes can alleviate late radiation effects, including cognitive changes RECENT PUBLICATIONS: Cherry, J.D., B. Liu, J.L. Frost, C.A. Lemere, J.P. Williams, J.A. Olschowka and M.K. O'Banion. 2012. Galactic cosmic radiation leads to cognitive impairment and increased Ab plaque accumulation in a mouse model of Alzheimer's disease. PLOS ONE 7:e53275. PMCID in process. Dilmanian, F.A., A.L. Jenkins, J. Olschowka, Z. Zhong, J.Y. Park, N.R. Desnoyers, S. Sobotka, G.R. Fois, C.R. Messina, M. Morales, S.D. Hurley, L.A. Trojanczyk, S. Ahmad, N. Shahrabi, P.K. Coyle, A.G. Meek and M.K. O'Banion. 2012. X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function. Rad. Res. Dec 5 [Epub ahead of print]. PMCID in process. Wu, M.D., A.M. Hein, M.J. Moravan, S.S. Shaftel, J.A. Olschowka and M.K. O'Banion. 2012. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1? and not rescued by voluntary running. Brain Behav. Immun. 26:292-300. PMCID: PMC3258353 Matousek, S.B., S. Ghosh, S.S. Shaftel, S. Kyrkanides, J.A. Olschowka and M.K. O'Banion. 2012. Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 7:156-164. PMCID: PMC3302720 Hein, A. M., T. J. Zarcone, D. B. Parfitt, S. B. Matousek, D. M. Carbonari, J. A. Olschowka and M. K. O'Banion. 2012. Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice. J. Neuroimmune Pharmacol. 7:145-155. PMCID: PMC3214690 Kyrkanides S., R.H. Tallents, J.N. Miller, M.E. Olschowka, R. Johnson, M. Yang, J.A. Olschowka, S.M. Brouxhon and M.K. O'Banion. 2011. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J. Neuroinflammation 8:112. PMCID: PMC3179730 Moravan, M.J., D.A. Olschowka, J.P. Williams and M.K. O'Banion. 2011. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat. Res. 176:459-473. PMCID: PMC3191189.

Credentials

Faculty Appointments

Education

1980
BS | Univ of Illinois-Urbana
Biology

1987
PhD | Univ of Illinois-Urbana
Microbiology

1987
MD | Univ of Illinois Coll Medicine
Medicine

Awards

1998
Graduate Student Society Faculty Teaching Award

1996 - 1999
George W. Corner Dean's Teaching Scholar

1988
Proficiency in Pediatrics Book Award

1987
M.D. with honors; Valedictorian Address

1987
Lange Book Award

1984
Otto Saphir Memorial Award in Pathology

1984
Alpha Omega Alpha (Honorary Medical Society)

1982
Excellence in Undergraduate Teaching Award

1980
Phi Kappa Phi (Honorary Society)

1980
B.S. with honors (summa cum laude); Bronze Tablet Recipient

1977 - 1980
Edmund J. James Scholar

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Publications

Journal Articles

9/2016
Heneka M, Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica MB, Takata K, Teeling J, Town T, Van Eldik LJ, Schulz JB. "Targeting innate immunity for neurodegenerative disorders of the central nervous system." Journal of neurochemistry.. 2016 Sep 0; 138(5):653-93.

2/3/2016
Moravan MJ, Olschowka JA, Williams JP, O'Banion MK. "Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling." Journal of neuroinflammation. 2016 Feb 3; 13:30. Epub 2016 Feb 03.

11/4/2015
Cherry JD, Olschowka JA, O'Banion MK. "Arginase 1+ microglia reduce A? plaque deposition during IL-1?-dependent neuroinflammation." Journal of neuroinflammation. 2015 Nov 4; 12:203. Epub 2015 Nov 04.

Books & Chapters

2001
Chapter Title: The cyclooxygenases in neuroinflammation and neurodegeneration: emerging perspectives.
Book Title: Inflammatory Events in Neurodegeneration
Author List: Maida, M. E.; M. K. O'Banion
Edited By: A. Cambell and S. C. Bondy
Published By: Prominent Press2001 in Scottsdale, AZ.

1999
Chapter Title: Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry.
Book Title: Eicosanoid Protocols
Author List: O'Banion, M. K.; J. A. Olschowka
Edited By: E. A. Lianos
Published By: Academic Press1999 in New York

1998
Chapter Title: Glial and neuronal expression of cyclooxygenase-2: relevance to Alzheimer's disease.
Book Title: Recent Advances in Prostaglandin, Thromboxane and Leukotriene Research
Author List: O'Banion, M. K.; A. Yermakova; J. W. Chang; M. D. Kaplan; P. D. Coleman
Edited By: H. Sinzinger, J. R. Vane, B. Samuelsson, PR. Paoletti, P.W. Ramwell, P. Y-K Wong
Published By: Plenum, New York1998

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