Gregory G. Tall, Ph.D.

Gregory G. Tall, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 273-2069
Lab: (585) 275-7490
Fax: (585) 273-2652

Research Bio

In canonical G protein signaling, G protein coupled receptors (GPCRs) activate heterotrimeric G proteins, which in turn regulate intracellular effector enzymes. Our lab studies G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. We found the biochemical function of one new G protein activator, Ric-8. Ric-8A activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. A major focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell. Observations made in genetic model systems suggest that Ric-8 proteins work with G proteins to regulate asymmetric cell division, the subcellular localization of G protein subunits, and as modulators of traditional GPCR signaling.

Recent Journal Articles

Showing the 5 most recent journal articles. 21 available »

2013 Aug 20
Tall GG, Patel BR, Chan P. "Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling." Proceedings of the National Academy of Sciences of the United States of America. 2013 Aug 20; 110(34):E3148. Epub 2013 Jul 12.
2013 Jun
Tall GG. "Ric-8 regulation of heterotrimeric G proteins." Journal of receptor and signal transduction research. 2013 Jun; 33(3):139-43. Epub 2013 Feb 06.
2013 Mar 5
Chan P, Thomas CJ, Sprang SR, Tall GG. "Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein ? subunits." Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 5; 110(10):3794-9. Epub 2013 Feb 19.
2013 Feb 1
Oner SS, Maher E, Gabay M, Tall GG, Blumer JB, Lanier SM. "Regulation of the G-protein regulatory-G?i signaling complex by nonreceptor guanine nucleotide exchange factors." The Journal of biological chemistry. 2013 Feb 1; 288(5):3003-15. Epub 2012 Dec 04.
2011 Nov 22
Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG. "Ric-8 proteins are molecular chaperones that direct nascent G protein ? subunit membrane association." Science signaling. 2011 Nov 22; 4(200):ra79. Epub 2011 Nov 22.


PhD | Biomedical Sciences | University of Texas Southwestern Medical Center2000
BS | Biochemistry and Cell Biology | Bucknell University1994