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Gregory G. Tall, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 275-1681

Biography

Research

In canonical G protein signaling, G protein coupled receptors (GPCRs) activate heterotrimeric G proteins, which in turn regulate intracellular effector enzymes. Our lab studies G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. We found the biochemical function of one new G protein activator, Ric-8. Ric-8A activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. A major focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell. Observations made in genetic model systems suggest that Ric-8 proteins work with G proteins to regulate asymmetric cell division, the subcellular localization of G protein subunits, and as modulators of traditional GPCR signaling.

Credentials

Education

2000
PhD | University of Texas Southwestern Medical Center
Biomedical Sciences

1994
BS | Bucknell University
Biochemistry and Cell Biology

Publications

Journal Articles

8/20/2013
Tall GG, Patel BR, Chan P. "Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Aug 20; 110(34):E3148. Epub 2013 Jul 12.

6/2013
Tall GG. "Ric-8 regulation of heterotrimeric G proteins." Journal of receptor and signal transduction research.. 2013 Jun 0; 33(3):139-43. Epub 2013 Feb 06.

3/5/2013
Chan P, Thomas CJ, Sprang SR, Tall GG. "Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein ? subunits." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Mar 5; 110(10):3794-9. Epub 2013 Feb 19.

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