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Michael C. Keefer, M.D.

Infectious Diseases

Clinical Interests

General Infectious Diseases

Contact Information

Phone Numbers

Fax: (585) 442-9328

Office: (585) 275-5871

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Research

Dr. Keefer has over 18 years of experience in the preventive HIV vaccine field, having served as Director of the University of Rochester's NIH-supported HIV Vaccine Trials Unit (HVTU) since 1991. Working initially as a laboratory investigator he was the first to demonstrate T-cell mediated immune responses to a candidate HIV vaccine. Subsequently he focused his attention on the design and conduct of clinical trials. When the HIV Vaccine Trials Network (HVTN) expanded to include international sites in 1999, he assumed the position of the HVTN's Associate Director of Scientific Administration. In that role his duties include leadership of scientific and administrative committees and visits to international sites. Dr Keefer is also PI of an NIH-funded Program Project entitled "HSV-1 amplicon vectors for HIV vaccine delivery", a collaboration with Drs. Dewhurst, Mosmann, Federoff and Bowers. Active Research U01 AI069511 2/1/2007 – 11/30/2014 PI: Richard C. Reichman, MD "Units for HIV/AIDS Clinical Trials Networks" The goals of the of the CTU are to develop a vaccine that will prevent HIV infection or delay the onset of symptomatic disease (HVTN) and to develop more effective treatments for established HIV infection in a variety of patient populations (ACTG). Role: Co-Investigator, Director of HIV Vaccine Trials Clinical Research Site U01 AI068614 6/29/2006 – 5/31/2013 PI: L Corey, M.D. NIH/NIAID Subcontract to University of Rochester (via Fred Hutchinson Cancer Research Center, Seattle, WA) Title: "HVTN Associate Director of Scientific Administration", The major goal is to establish a Vaccine Leadership Group to direct and coordinate the HIV Vaccine Trials Network's (HVTN) work in domestic and international settings. Dr. Keefer functions in a 40% FTE capacity as a key member of the network's Core Operations Center, focused primarily on the establishment and execution of the network's scientific agenda for Phase I/II studies. Role: PI of Subcontract at Rochester P01 AI056356, HIV Vaccine Research and Design NIH/NIAID Title: "HSV-1 Amplicon Vectors for HIV Vaccine Delivery" PI: MC Keefer, M.D. 1/1/2003 – 12/31/2008 The overall goal of this Program Project is to develop an HIV vaccine strategy based on the HSV-1 amplicon vector, and to test this approach in small and large animal models. The HSV amplicon vector will be tested alone and in combination with a DNA vaccine provided by the NIAID Vaccine Research Center. The proposal includes 3 projects (immunogenicity in mice/guinea pigs; immunogenicity/protection in macaques; enhancement of amplicon technology) and 3 cores (administrative; immunologic; vector production). P30 AI-078498, Center for AIDS Research (CFAR) program NIH Title: "University of Rochester Developmental Center for AIDS Research (D-CFAR)" PI: S Dewhurst, Ph.D. 5/1/2008 – 4/30/2013 The primary mission of the University of Rochester D-CFAR is to raise the overall quality and quantity of HIV/AIDS research at the UR. This objective will be achieved by the establishment of four interconnected core facilities (Administrative Core, Developmental Core, Clinical Science Core and Basic Science Core) that synergize with the UR Clinical and Translational Science Institute to provide new opportunities for collaboration among establish investigators and those who are new to the field. Major goals are to augment the availability of biostatistical and data management services, to increase the use of mathematical modeling in HIV/AIDS research and to establish new collaborations between UR investigators and colleagues at the University of Witwatersrand and University of Cape Town in South Africa. Role: Co-PI of D-CFAR, Director of 'Clinical Sciences Core', and Leader of 'International Collaboration Committee'.

Credentials

Faculty Appointments

Specialties

  • Infectious Disease - American Board of Internal Medicine
  • Internal Medicine - American Board of Internal Medicine

Education

1978
BA | Miami University
Zoology

1983
MD | Wright State Univ School Med
Medicine

Post-doctoral Training & Residency

09/01/1987 - 05/31/1990
Fellowship in Internal Medicine: Infectious Disease at Univ. of Rochester School of Medicine and Dentistry

01/01/1983 - 12/31/1983
Internship in Internal Medicine at Christ Hospital

01/01/1984 - 12/31/1987
Residency in Internal Medicine at Christ Hospital

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Publications

Journal Articles

2/12/2017
Janes HE, Cohen KW, Frahm N, De Rosa SC, Sanchez B, Hural J, Magaret CA, Karuna S, Bentley C, Gottardo R, Finak G, Grove D, Shen M, Graham BS, Koup RA, Mulligan MJ, Koblin B, Buchbinder SP, Keefer MC, Adams E, Anude C, Corey L, Sobieszczyk M, Hammer SM, Gilbert PB, McElrath MJ. "Higher T cell responses induced by DNA/rAd5 HIV-1 preventive vaccine are associated with lower HIV-1 infection risk in an efficacy trial." The Journal of infectious diseases.. 2017 Feb 12; Epub 2017 Feb 12.

2017
Jaworski JP, Bryk P, Brower Z, Zheng B, Hessell AJ, Rosenberg AF, Wu TT, Sanz I, Keefer MC, Haigwood NL, Kobie JJ. "Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques." PloS one. 2017 12(2):e0172524. Epub 2017 Feb 21.

2/15/2016
Walsh SR, Moodie Z, Fiore-Gartland AJ, Morgan C, Wilck MB, Hammer SM, Buchbinder SP, Kalams SA, Goepfert PA, Mulligan MJ, Keefer MC, Baden LR, Swann EM, Grant S, Ahmed H, Li F, Hertz T, Self SG, Friedrich D, Frahm N, Liao HX, Montefiori DC, Tomaras GD, McElrath MJ, Hural J, Graham BS, Jin X, . "Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083." The Journal of infectious diseases.. 2016 Feb 15; 213(4):541-50. Epub 2015 Oct 15.

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