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Sherry L. Spinelli, Ph.D.


Showing all 44 journal articles & 0 books available

Journal Articles

Lannan KL, Spinelli SL, Blumberg N, Phipps RP. "Maresin 1 induces a novel pro-resolving phenotype in human platelets." Journal of thrombosis and haemostasis : JTH.. 2017 Apr 0; 15(4):802-813. Epub 2017 Feb 25.

Spinelli SL, Lannan KL, Loelius SG, Phipps RP. "In Vitro and Ex Vivo Approaches to Evaluate Next-Generation Tobacco and Non-Tobacco Products on Human Blood Platelets." Applied in vitro toxicology.. 2017 Mar 1; 3(1):110-120.

Damien P, Cognasse F, Payrastre B, Spinelli SL, Blumberg N, Arthaud CA, Eyraud MA, Phipps RP, McNicol A, Pozzetto B, Garraud O, Hamzeh-Cognasse H. "NF-?B Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets." Frontiers in immunology. 2017 8:85. Epub 2017 Feb 06.

Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, Spinelli SL. "Resveratrol preserves the function of human platelets stored for transfusion." British journal of haematology.. 2016 Mar 0; 172(5):794-806. Epub 2015 Dec 18.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spineli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Blumberg N. "Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery." Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2015 Mar 0; 16(3):227-35.

Stolla M, Refaai MA, Heal JM, Spinelli SL, Garraud O, Phipps RP, Blumberg N. "Platelet transfusion - the new immunology of an old therapy." Frontiers in immunology. 2015 6:28. Epub 2015 Feb 02.

Lannan KL, Sahler J, Kim N, Spinelli SL, Maggirwar SB, Garraud O, Cognasse F, Blumberg N, Phipps RP. "Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles." Frontiers in immunology. 2015 6:48. Epub 2015 Feb 13.

Spinelli SL, Xi X, McMillan DH, Woeller CF, Richardson ME, Cavet ME, Zhang JZ, Feldon SE, Phipps RP. "Mapracorat, a selective glucocorticoid receptor agonist, upregulates RelB, an anti-inflammatory nuclear factor-kappaB protein, in human ocular cells." Experimental eye research.. 2014 Oct 0; 127:290-8.

Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N. "Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro." Transfusion.. 2014 Jun 0; 54(6):1569-79. Epub 2013 Nov 05.

McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP. "Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts." American journal of physiology. Lung cellular and molecular physiology.. 2013 Jun 1; 304(11):L774-81. Epub 2013 Apr 05.

Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N. "Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B." Transfusion.. 2013 Feb 0; 53(2):382-93. Epub 2012 May 25.

Lannan KL, Sahler J, Spinelli SL, Phipps RP, Blumberg N. "Transfusion immunomodulation--the case for leukoreduced and (perhaps) washed transfusions." Blood cells, molecules & diseases.. 2013 Jan 0; 50(1):61-8. Epub 2012 Sep 13.

Sahler J., Spinelli S., Phipps R., Blumberg N. "CD40 ligand (CD154) involvement in platelet transfusion reactions." Transfus Clin Biol. 2012; 19(3): 98-103.

Cholette JM, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Lerner NB, Blumberg N. "Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial." Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2012 May 0; 13(3):290-9.

Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N. "An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients." Vox sanguinis.. 2011 Jul 0; 101(1):55-60. Epub 2011 Mar 18.

Sahler J, Bernard JJ, Spinelli SL, Blumberg N, Phipps RP. "The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-?B inhibition." Thrombosis research.. 2011 May 0; 127(5):426-34. Epub 2011 Jan 26.

Refaai MA, Phipps RP, Spinelli SL, Blumberg N. "Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes." Thrombosis research.. 2011 Apr 0; 127(4):287-91. Epub 2010 Nov 19.

Grimshaw K, Sahler J, Spinelli SL, Phipps RP, Blumberg N. "New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells." Transfusion.. 2011 Apr 0; 51(4):874-80.

Davidson DC, Hirschman MP, Spinelli SL, Morrell CN, Schifitto G, Phipps RP, Maggirwar SB. "Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 Jan 1; 186(1):584-91. Epub 2010 Nov 29.

Refaai MA, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Francis CW, Blumberg N. "Platelet Activation Following Exposure to Anti-ABO Antibodies-An In Vitro Study." US oncology & hematology.. 2011 Jan 1; 7(1):72-74.

Sahler J, Grimshaw K, Spinelli SL, Refaai MA, Phipps RP, Blumberg N. "Platelet storage and transfusions: new concerns associated with an old therapy." Drug discovery today. Disease mechanisms. 2011 8(1-2):e9-e14. Epub 2011 Jul 20.

Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP. "A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis." Journal of biotechnology.. 2010 Nov 0; 150(3):417-27. Epub 2010 Oct 01.

Spinelli SL, Maggirwar SB, Blumberg N, Phipps RP. "Nuclear emancipation: a platelet tour de force." Science signaling. 2010 Oct 19; 3(144):pe37. Epub 2010 Oct 19.

Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RP. "Platelets and megakaryocytes contain functional nuclear factor-kappaB." Arteriosclerosis, thrombosis, and vascular biology.. 2010 Mar 0; 30(3):591-8. Epub 2009 Dec 30.

Sahler, J.S.; Spinelli, S.L.; Phipps, R.P.; Blumberg, N. "Thrombosis Research at the University of Rochester Medical Center." Int Rev Throm. 2010; 5: 40-48.

Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP. "The platelet as an immune cell-CD40 ligand and transfusion immunomodulation." Immunologic research.. 2009 Dec 0; 45(2-3):251-60. Epub 2009 Jan 29.

Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP. "Foxp3 regulates megakaryopoiesis and platelet function." Arteriosclerosis, thrombosis, and vascular biology.. 2009 Nov 0; 29(11):1874-82. Epub 2009 Aug 06.

Springer D, Miller J, Spinelli S, Pasa-Tolic L, Purvine S, Daly D, Zangar R, Jin S, Blumberg N, Francis C, Taubman M, Casey A, Wittlin S, Phipps R. "Platelet proteome changes associated with diabetes and during platelet storage for transfusion." Journal of proteome research.. 2009 May 0; 8(5):2261-72.

O'Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP. "15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes." Blood.. 2008 Nov 15; 112(10):4051-60. Epub 2008 Aug 28.

Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP. "Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles." Thrombosis and haemostasis.. 2008 Jan 0; 99(1):86-95.

Spinelli SL, O'Brien JJ, Bancos S, Lehmann GM, Springer DL, Blumberg N, Francis CW, Taubman MB, Phipps RP. "The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects." PPAR research. 2008 2008:328172.

Kaufman J, Spinelli SL, Schultz E, Blumberg N, Phipps RP. "Release of biologically active CD154 during collection and storage of platelet concentrates prepared for transfusion." Journal of thrombosis and haemostasis : JTH.. 2007 Apr 0; 5(4):788-96.

O'Brien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP. "The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands." Prostaglandins & other lipid mediators. 2007 Jan 0; 82(1-4):68-76. Epub 2006 Jul 10.

Jamie J. O'Brien; Denise M. Ray; Sherry L. Spinelli; Neil Blumberg; Mark B. Taubman; Charles W. Francis; Steven D. Wittlin; Richard P. Phipps. "The Platelet as a Therapeutic Target for Treating Vascular Diseases and the Role of Eicosanoid and Synthetic PPAR gamma Ligands". Prostaglandins and Other Lipid Mediators. Prostaglandins and Other Lipid Mediators. 2007; 82: 68-76.

Ray DM, Spinelli SL, O'Brien JJ, Blumberg N, Phipps RP. "Platelets as a novel target for PPARgamma ligands : implications for inflammation, diabetes, and cardiovascular disease." BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2006 20(4):231-41.

Shull NP, Spinelli SL, Phizicky EM. "A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae." Nucleic acids research.. 2005 33(2):650-60. Epub 2005 Jan 31.

Ruschak AM, Mathews DH, Bibillo A, Spinelli SL, Childs JL, Eickbush TH, Turner DH. "Secondary structure models of the 3' untranslated regions of diverse R2 RNAs." RNA.. 2004 Jun 0; 10(6):978-87.

Phizicky EM, Martzen MR, McCraith SM, Spinelli SL, Xing F, Shull NP, Van Slyke C, Montagne RK, Torres FM, Fields S, Grayhack EJ. "Biochemical genomics approach to map activities to genes." Methods in enzymology.. 2002 350:546-59.

Kierzek R, Steiger MA, Spinelli SL, Turner DH, Phizicky EM. "The chemical synthesis of oligoribonucleotides with selectively placed 2'-O-phosphates." Nucleosides, nucleotides & nucleic acids. 2000 19(5-6):917-33.

Martzen MR, McCraith SM, Spinelli SL, Torres FM, Fields S, Grayhack EJ, Phizicky EM. "A biochemical genomics approach for identifying genes by the activity of their products." Science.. 1999 Nov 5; 286(5442):1153-5.

Spinelli SL, Kierzek R, Turner DH, Phizicky EM. "Transient ADP-ribosylation of a 2'-phosphate implicated in its removal from ligated tRNA during splicing in yeast." The Journal of biological chemistry.. 1999 Jan 29; 274(5):2637-44.

Spinelli SL, Malik HS, Consaul SA, Phizicky EM. "A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli." Proceedings of the National Academy of Sciences of the United States of America.. 1998 Nov 24; 95(24):14136-41.

Spinelli SL, Consaul SA, Phizicky EM. "A conditional lethal yeast phosphotransferase (tpt1) mutant accumulates tRNAs with a 2'-phosphate and an undermodified base at the splice junction." RNA.. 1997 Dec 0; 3(12):1388-400.

Sowden M, Hamm JK, Spinelli S, Smith HC. "Determinants involved in regulating the proportion of edited apolipoprotein B RNAs." RNA.. 1996 Mar 0; 2(3):274-88.