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Sherry L. Spinelli, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-3762

Biography

Research

Platelets are anucleate cells released from megakaryocytes that circulate in the vascular system. Their importance and function in hemostasis is well known. Our (Drs. Neil Blumberg, Richard Phipps and myself) research interests lie in the emerging concept that platelets have a significant role in the mediation of inflammation and immunoregulation. Of particular interest is the nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), part of a superfamily of ligand-activated receptors involved in transcriptional regulation of genes in energy metabolism and adipocyte differentiation. Several cell types including lymphocytes, fibroblasts, and endothelial cells express PPARgamma. Interestingly, our laboratory has recently demonstrated that human platelets also express PPARgamma and receptor binding of PPARgamma by PPARgamma agonists reduces platelet release of proinflammatory mediators. This is of major significance as platelet activation is linked to several diseases including atherosclerosis, insulin resistance in type II diabetes, and cancer. My goal is to understand the role of platelet PPARgamma in inflammation. This research is conducted in collaboration with the laboratory of Dr. Richard Phipps.

Platelet transfusion can cause a life-threatening inflammatory response. Upon activation, platelets undergo rapid morphological changes, and release bioactive mediators including chemokines, prostaglandins and growth factors that elicit a variety of responses. We will investigate the role of platelet-released proinflammatory mediators in transfusion-associated inflammation and multi-organ failure. Our goal is to develop a therapeutic strategy to reduce the risk of inflammatory responses in patients transfused with platelets.

Credentials

Faculty Appointments

Education

1999
PhD | Univ Rochester Sch Med/Dent
Biochemistry

1997
MS | Univ Rochester Sch Med/Dent
Biochemistry

1994
BS | SUNY Coll at Brockport
Biology

Awards

2004
Regional Trio Achiever Award

1999
Walter S. Bloor Award

1998 - 1999
Elon Huntington Hooker Graduate Research Fellowship

1994 - 1996
Stotz Fellowship

1994
Sigma Xi Award for Research

1994
EMSA Undergraduate Scholarship

1993 - 1994
Ronald E. McNair Program

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Publications

Journal Articles

4/2017
Lannan KL, Spinelli SL, Blumberg N, Phipps RP. "Maresin 1 induces a novel pro-resolving phenotype in human platelets." Journal of thrombosis and haemostasis : JTH.. 2017 Apr 0; 15(4):802-813. Epub 2017 Feb 25.

3/1/2017
Spinelli SL, Lannan KL, Loelius SG, Phipps RP. "In Vitro and Ex Vivo Approaches to Evaluate Next-Generation Tobacco and Non-Tobacco Products on Human Blood Platelets." Applied in vitro toxicology.. 2017 Mar 1; 3(1):110-120.

2017
Damien P, Cognasse F, Payrastre B, Spinelli SL, Blumberg N, Arthaud CA, Eyraud MA, Phipps RP, McNicol A, Pozzetto B, Garraud O, Hamzeh-Cognasse H. "NF-?B Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets." Frontiers in immunology. 2017 8:85. Epub 2017 Feb 06.

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