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Gary D. Paige, M.D., Ph.D.

Neurology

Contact Information

Phone Numbers

Appointment: (585) 275-6395

Office: (585) 275-6395

Fax: (585) 442-8766

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients

Research Labs

Spatial Orientation Research

Visit Lab Website

Biography

Balance Disorders and Dizziness Clinic
http://www.urmc.rochester.edu/balance-clinic/

Research

Multisensory Interaction and Adaptive Plasticity in Spatial Localization and Orientation.

The sensori-neural processes underlying our abilities to localize, track, and interact with a cluttered environment are crucial attributes of daily life, and are among the most fundamental tasks of the nervous system. The integration of multiple sensory inputs are required to guide spatial behaviors, ranging from mundane tasks such as reaching for objects to complex ones such as navigating to and from the workplace. These functions are also among the first (and often most subtle) to register problems after head trauma, neurological disease, and aging. The goal of our research is to understand how the brain integrates sensory inputs from the outside world (location and motion of visual and auditory targets) with those of the internal senses (vestibular and somatosensory depictions of orientation and motion of the body and its parts,) to achieve meaningful spatial perceptions and behaviors (eye, head and postural movements and reflexes). An equally important interest is how plastic neural mechanisms register errors and adaptively adjust performance in order to maintain proper spatial calibration across sensory modalities, or analogously, recover normal function after suffering pathologic loss. Finally, an important translational concern is how the neural degeneration of natural aging affects spatial behavior and plasticity. Recent experiments have addressed two intriguing areas of interest. One is understanding how the brain utilizes auditory and visual information about target location and motion in order to maintain accurate and congruent spatial calibration across modalities, as assessed through different forms of orienting movements ("pointing"). These include visually-guided manual pointing by laser joystick, and more natural gaze (eye and head) pointing. Since gaze shifts activate vestibular reflexes (vestibulo-ocular and –collic reflexes: VOR and VCR) as well as somatosensory feedback from the neck, we have addressed how the senses interact with each other and with volitional and reflex motor control. We also investigated the important challenges of spatial memory when targets are transient, as occurs frequently in nature. Finally, we maintain interest in how spatial sensory modalities are plastically co-calibrated by cross-sensory experience--an essential feature normal spatial behavior over a lifetime.


A second focus has addressed vestibular inputs during both angular (from the semicircular canals) and linear (from the otoliths) head motion and how they interact with each other, despite an intriguing limitation in the physics of the linear form (Einstein's "equivalency principle"). As biological linear accelerometers, the otolith organs cannot readily distinguish accelerations due to head tilt (relative to gravity) from those arising during translational (as opposed to angular) motion, and yet relevant behaviors and perceptions associated with these two forms of motion differ greatly.


The lab has completed a set of studies related to the above topics, and witnessed several graduate students through completion of PhD requirements. I have returned to largely a clinical role related to disorders of balance and equilibrium--a cross between neuro-otology and neuro-ophthalmology--and serve in an advisory role for students and others at all levels.

Credentials

Faculty Appointments

Specialties

  • Ophthalmology - American Board of Ophthalmology

Education

1970
Secondary Education | Interlochen Arts Academy
Major in music, minor in broadcasting

1974
BS | University of California Irvine
Biological Sciences

1980
PhD | University of Chicago
Neurophysiology

1981
MD | Pritzker School of Medicine, University of Chicago
Medicine

Post-doctoral Training & Residency

07/01/1982 - 06/30/1985
Residency in Ophthalmology at University of California, San Francisco Medical Center

07/01/1981 - 06/30/1982
Internship in Anesthesiology at Michael Reese Hospital and Medical Center

Awards

2013
Commencement Address
Sponsor: Master's Ceremony
Location: Kilbourn Hall, University of Rochester

2010 - Present
President
Sponsor: Society for the Neural Control of Movement

2007 - 2010
Vice President and Program Director
Sponsor: Society for the Neural Control of Movement

2002 - 2004
President
Sponsor: Association of Medical School Neuroscience Department Chairs.

1999
Stadium Generale (keynote) Presentation
Location: Nijmegen Institute of Neuroscience

1997
Arthur Kornberg Research Award
Sponsor: University of Rochester

1995 - Present
Honory Life Member
Sponsor: Neuro-Otological Society of Australia

1991
Traveling Fellowship
Sponsor: Royal College of Surgeons Foundation
Location: Ossining, New York

1984
Michael J. Hogan Award
Sponsor: Dept. Opthalmology, University of California
Location: San Francisco, Calif.

1975 - 1981
Medical Scientist Training Program (MD, PhD)
Location: University of Chicago

1974 - 1975
J. Franks Fund Scholarship Award
Sponsor: University of Chicago Pritzker School of Medicine

1974
B.S. Cum Laude and With Honors
Sponsor: University of California - Irvine

1972
National Science Foundation Research Participation Award
Sponsor: Department of Psychobiology, University of California - Irvine

1970
Academic Honors Award
Sponsor: Interlochen Arts Academy

1966 - 1970
Dow Foundation Scholarship
Sponsor: Interlochen Arts Academy

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Publications

Journal Articles

2017
Bosen AK, Fleming JT, Allen PD, O'Neill WE, Paige GD. "Accumulation and decay of visual capture and the ventriloquism aftereffect caused by brief audio-visual disparities." Experimental brain research.. 2017 235(2):585-595. Epub 2016 Nov 11.

12/2016
Bosen AK, Fleming JT, Brown SE, Allen PD, O'Neill WE, Paige GD. "Comparison of congruence judgment and auditory localization tasks for assessing the spatial limits of visual capture." Biological cybernetics.. 2016 Dec 0; 110(6):455-471. Epub 2016 Nov 04.

12/2012
Dobreva MS, O'Neill WE, Paige GD. "Influence of age, spatial memory, and ocular fixation on localization of auditory, visual, and bimodal targets by human subjects." Experimental brain research.. 2012 Dec 0; 223(4):441-55. Epub 2012 Oct 14.

Books & Chapters

2008
Chapter Title: Eye Position and Cross-Sensory Learning both Contribute to Prism Adaptation of Auditory Space.
Book Title: Brain Res.
Author List: Cui, Q.N., O'Neill, Bachus, L, Knoth, E., W.E. and Paige, G.D.
Edited By: C. Kennard and R.J. Leigh
Published By: Elsevier2008

1997
Chapter Title: Torsional Eye Movements Evoked by Unilateral Galvanic Polarization in the Squirrel Monkey
Book Title: Three-Dimensional Kinematic Principles of Eye, Head, and Limb Movements
Author List: Minor, L.B., Tomko, D.L., Paige, G.D.
Edited By: Fetter M, Haslwanter T, Misslisch H, Tweed D
Published By: Harwood Academic Publishers GNBH, Chur, Switzerland1997

1997
Chapter Title: The VOR During Head Roll: Distinctive Properties Related to Visual Demands
Book Title: Three-Dimensional Kinematic Principles of Eye, Head, and Limb Movements
Author List: Seidman, S.H., Paige, G.D., Leigh, R.J.
Edited By: Fetter M, Haslwanter T, Misslisch H, Tweed D
Published By: Harwood Academic Publishing GNBH, Chur, Switzerland1997

VIEW ALL PUBLICATIONS

Videos

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SECOND OPINION | Dizziness | APT | Full Episode

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SECOND OPINION | Dizziness | APT | Webisode