Giovanni Schifitto, M.D., M.S.

Giovanni Schifitto, M.D., M.S.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 673
Rochester, NY 14642

Office: (585) 275-3052
Fax: (585) 276-1870

Journal Articles

Showing all 63 journal articles available.

2010 Feb 2
Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R, . "Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial." Neurology. 2010 Feb 2; 74(5):413-20.
2010 Feb
Cohen RA, Harezlak J, Schifitto G, Hana G, Clark U, Gongvatana A, Paul R, Taylor M, Thompson P, Alger J, Brown M, Zhong J, Campbell T, Singer E, Daar E, McMahon D, Tso Y, Yiannoutsos CT, Navia B. "Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era." Journal of neurovirology. 2010 Feb; 16(1):25-32.
2010 Jan 15
Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE. "Neuroprotective activities of CEP-1347 in models of neuroAIDS." The Journal of immunology : official journal of the American Association of Immunologists. 2010 Jan 15; 184(2):746-56. Epub 2009 Dec 04.
2009 Dec 8
Schifitto G, Yiannoutsos CT, Ernst T, Navia BA, Nath A, Sacktor N, Anderson C, Marra CM, Clifford DB, . "Selegiline and oxidative stress in HIV-associated cognitive impairment." Neurology. 2009 Dec 8; 73(23):1975-81. Epub 2009 Nov 04.
2009 Dec
Dicenzo R, Difrancesco R, Cruttenden K, Donnelly J, Schifitto G. "Lopinavir cerebrospinal fluid steady-state trough concentrations in HIV-infected adults." The Annals of pharmacotherapy. 2009 Dec; 43(12):1972-7. Epub 2009 Nov 24.
2009 Jul 17
Marra CM, Zhao Y, Clifford DB, Letendre S, Evans S, Henry K, Ellis RJ, Rodriguez B, Coombs RW, Schifitto G, McArthur JC, Robertson K, . "Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance." AIDS. 2009 Jul 17; 23(11):1359-66.
2009 Apr
Schifitto G, Zhong J, Gill D, Peterson DR, Gaugh MD, Zhu T, Tivarus M, Cruttenden K, Maggirwar SB, Gendelman HE, Dewhurst S, Gelbard HA. "Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment." Journal of neurovirology. 2009 Apr; 15(2):176-86.
2009 Feb
Zhu T, Liu X, Gaugh MD, Connelly PR, Ni H, Ekholm S, Schifitto G, Zhong J. "Evaluation of measurement uncertainties in human diffusion tensor imaging (DTI)-derived parameters and optimization of clinical DTI protocols with a wild bootstrap analysis." Journal of magnetic resonance imaging : JMRI. 2009 Feb; 29(2):422-35.
2008 Sep
DiCenzo R, Peterson DR, Cruttenden K, Mariuz P, Rezk NL, Hochreiter J, Gelbard H, Schifitto G. "Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir." Antimicrobial agents and chemotherapy. 2008 Sep; 52(9):3035-9. Epub 2008 Jun 23.
2008 Aug 12
Schifitto G, Friedman JH, Oakes D, Shulman L, Comella CL, Marek K, Fahn S, . "Fatigue in levodopa-naive subjects with Parkinson disease." Neurology. 2008 Aug 12; 71(7):481-5.
Evans,S.R.; Clifford,D.B.; Kitch,D.W.; Goodkin,K.; Schifitto,G.; McArthur,J.C.; Simpson,D.M.;. "Simplification of the Research Diagnosis of HIV-Associated Sensory Neuropathy". HIV Clin Trials. 2008; 9(6): 434-439. Link
2007 Sep 25
Schifitto G, Zhang J, Evans SR, Sacktor N, Simpson D, Millar LL, Hung VL, Miller EN, Smith E, Ellis RJ, Valcour V, Singer E, Marra CM, Kolson D, Weihe J, Remmel R, Katzenstein D, Clifford DB, . "A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment." Neurology. 2007 Sep 25; 69(13):1314-21. Epub 2007 Jul 25.
2007 Sep 12
Schifitto G, Navia BA, Yiannoutsos CT, Marra CM, Chang L, Ernst T, Jarvik JG, Miller EN, Singer EJ, Ellis RJ, Kolson DL, Simpson D, Nath A, Berger J, Shriver SL, Millar LL, Colquhoun D, Lenkinski R, Gonzalez RG, Lipton SA, , , . "Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study." AIDS. 2007 Sep 12; 21(14):1877-86.
2007 Sep 3
DiFrancesco R, DiCenzo R, Vicente G, Donnelly J, Martin TM, Colon LA, Schifito G, Morse GD. "Determination of lopinavir cerebral spinal fluid and plasma ultrafiltrate concentrations by liquid chromatography coupled to tandem mass spectrometry." Journal of pharmaceutical and biomedical analysis. 2007 Sep 3; 44(5):1139-46. Epub 2007 May 25.
2007 Sep
Wachtman LM, Skolasky RL, Tarwater PM, Esposito D, Schifitto G, Marder K, McDermott MP, Cohen BA, Nath A, Sacktor N, Epstein LG, Mankowski JL, McArthur JC. "Platelet decline: an avenue for investigation into the pathogenesis of human immunodeficiency virus -associated dementia." Archives of neurology. 2007 Sep; 64(9):1264-72.
2007 Mar 1
Sui Z, Sniderhan LF, Schifitto G, Phipps RP, Gelbard HA, Dewhurst S, Maggirwar SB. "Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia." The Journal of immunology : official journal of the American Association of Immunologists. 2007 Mar 1; 178(5):3226-36.
2007 Mar
Dewhurst S, Maggirwar SB, Schifitto G, Gendelman HE, Gelbard HA. "Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2007 Mar; 2(1):93-6. Epub 2006 Dec 16.
2007 Jan 30
Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A, Tanner CM. "Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030." Neurology. 2007 Jan 30; 68(5):384-6. Epub 2006 Nov 02.
2007 Jan
Sevigny JJ, Albert SM, McDermott MP, Schifitto G, McArthur JC, Sacktor N, Conant K, Selnes OA, Stern Y, McClernon DR, Palumbo D, Kieburtz K, Riggs G, Cohen B, Marder K, Epstein LG. "An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection." Archives of neurology. 2007 Jan; 64(1):97-102.
Paul RH, Yiannoutsos CT, Miller EN, Chang L, Marra CM, Schifitto G, Ernst T, Singer E, Richards T, Jarvik GJ, Price R, Meyerhoff DJ, Kolson D, Ellis RJ, Gonzalez G, Lenkinski RE, Cohen RA, Navia BA. "Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity." The Journal of neuropsychiatry and clinical neurosciences. 2007 19(3):283-92.
Evans SR, Yeh TM, Sacktor N, Clifford DB, Simpson D, Miller EN, Ellis RJ, Valcour V, Marra CM, Millar L, Schifitto G, . "Selegiline transdermal system (STS) for HIV-associated cognitive impairment: open-label report of ACTG 5090." HIV clinical trials. 2007 8(6):437-46.
2006 Aug
Schifitto G, Yiannoutsos CT, Simpson DM, Marra CM, Singer EJ, Kolson DL, Nath A, Berger JR, Navia B, . "A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy." Journal of neurovirology. 2006 Aug; 12(4):328-31.
2006 Jul 1
Sui Z, Fan S, Sniderhan L, Reisinger E, Litzburg A, Schifitto G, Gelbard HA, Dewhurst S, Maggirwar SB. "Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Jul 1; 177(1):702-11.
2006 Jun 13
Simpson DM, Kitch D, Evans SR, McArthur JC, Asmuth DM, Cohen B, Goodkin K, Gerschenson M, So Y, Marra CM, Diaz-Arrastia R, Shriver S, Millar L, Clifford DB, . "HIV neuropathy natural history cohort study: assessment measures and risk factors." Neurology. 2006 Jun 13; 66(11):1679-87.
2006 Mar 28
Schifitto G, Peterson DR, Zhong J, Ni H, Cruttenden K, Gaugh M, Gendelman HE, Boska M, Gelbard H. "Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report." Neurology. 2006 Mar 28; 66(6):919-21. Epub 2006 Mar 01.
2006 Mar 28
Herrmann DN, McDermott MP, Sowden JE, Henderson D, Messing S, Cruttenden K, Schifitto G. "Is skin biopsy a predictor of transition to symptomatic HIV neuropathy? A longitudinal study." Neurology. 2006 Mar 28; 66(6):857-61.
2005 Apr
Sacktor N, Skolasky RL, Ernst T, Mao X, Selnes O, Pomper MG, Chang L, Zhong K, Shungu DC, Marder K, Shibata D, Schifitto G, Bobo L, Barker PB. "A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia." Journal of magnetic resonance imaging : JMRI. 2005 Apr; 21(4):325-33.
2005 Mar 8
Schifitto G, McDermott MP, McArthur JC, Marder K, Sacktor N, McClernon DR, Conant K, Cohen B, Epstein LG, Kieburtz K, . "Markers of immune activation and viral load in HIV-associated sensory neuropathy." Neurology. 2005 Mar 8; 64(5):842-8.
2004 Dec 14
Sevigny JJ, Albert SM, McDermott MP, McArthur JC, Sacktor N, Conant K, Schifitto G, Selnes OA, Stern Y, McClernon DR, Palumbo D, Kieburtz K, Riggs G, Cohen B, Epstein LG, Marder K. "Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia." Neurology. 2004 Dec 14; 63(11):2084-90.
2004 Dec 9
Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, Olanow CW, Tanner C, Marek K, . "Levodopa and the progression of Parkinson's disease." The New England journal of medicine. 2004 Dec 9; 351(24):2498-508.
2004 Dec
Chang L, Lee PL, Yiannoutsos CT, Ernst T, Marra CM, Richards T, Kolson D, Schifitto G, Jarvik JG, Miller EN, Lenkinski R, Gonzalez G, Navia BA, . "A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age." NeuroImage. 2004 Dec; 23(4):1336-47.
2004 Nov
DiCenzo R, Peterson D, Cruttenden K, Morse G, Riggs G, Gelbard H, Schifitto G. "Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults." Antimicrobial agents and chemotherapy. 2004 Nov; 48(11):4328-31.
2004 Nov
Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra CM, Meyerhoff DJ, Jarvik JG, Kolson D, Schifitto G, Ellis RJ, Swindells S, Simpson DM, Miller EN, Gonzalez RG, Navia BA. "Regional patterns of brain metabolites in AIDS dementia complex." NeuroImage. 2004 Nov; 23(3):928-35.
2004 Nov
McArthur JC, McDermott MP, McClernon D, St Hillaire C, Conant K, Marder K, Schifitto G, Selnes OA, Sacktor N, Stern Y, Albert SM, Kieburtz K, deMarcaida JA, Cohen B, Epstein LG. "Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy." Archives of neurology. 2004 Nov; 61(11):1687-96.
2004 Mar
Herrmann DN, McDermott MP, Henderson D, Chen L, Akowuah K, Schifitto G, . "Epidermal nerve fiber density, axonal swellings and QST as predictors of HIV distal sensory neuropathy." Muscle & nerve. 2004 Mar; 29(3):420-7.
2003 Jun
Lee PL, Yiannoutsos CT, Ernst T, Chang L, Marra CM, Jarvik JG, Richards TL, Kwok EW, Kolson DL, Simpson D, Tang CY, Schifitto G, Ketonen LM, Meyerhoff DJ, Lenkinski RE, Gonzalez RG, Navia BA, . "A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis." Journal of magnetic resonance imaging : JMRI. 2003 Jun; 17(6):625-33.
2003 May 13
Marder K, Albert SM, McDermott MP, McArthur JC, Schifitto G, Selnes OA, Sacktor N, Stern Y, Palumbo D, Kieburtz K, Cohen B, Orme C, Epstein LG. "Inter-rater reliability of a clinical staging of HIV-associated cognitive impairment." Neurology. 2003 May 13; 60(9):1467-73.
2003 May 13
Simpson DM, McArthur JC, Olney R, Clifford D, So Y, Ross D, Baird BJ, Barrett P, Hammer AE, . "Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial." Neurology. 2003 May 13; 60(9):1508-14.
2003 Jan 28
Turchan J, Pocernich CB, Gairola C, Chauhan A, Schifitto G, Butterfield DA, Buch S, Narayan O, Sinai A, Geiger J, Berger JR, Elford H, Nath A. "Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants." Neurology. 2003 Jan 28; 60(2):307-14.
2002 Oct
Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M, . "Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline." Archives of neurology. 2002 Oct; 59(10):1541-50.
2002 Apr
Sacktor N, McDermott MP, Marder K, Schifitto G, Selnes OA, McArthur JC, Stern Y, Albert S, Palumbo D, Kieburtz K, De Marcaida JA, Cohen B, Epstein L. "HIV-associated cognitive impairment before and after the advent of combination therapy." Journal of neurovirology. 2002 Apr; 8(2):136-42.
2002 Feb 15
Simpson DM, Haidich AB, Schifitto G, Yiannoutsos CT, Geraci AP, McArthur JC, Katzenstein DA, . "Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levels." AIDS. 2002 Feb 15; 16(3):407-12.
Clifford,D.B.; McArthur,J.C.; Schifitto,G.; Kieburtz,K.; McDermott,M.P.; Letendre,S.; Cohen,B.A.; Marder,K.; Ellis,R.J.; Marra,C.M.; Neurological AIDS Research Consortium;. "A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment". Neurol. 2002; 59: 1568-1573.
Polydefkis,M.; Yiannoutsos,C.; Cohen,B.; Hollander,H.; Schifitto,G.; Clifford,D.B.; Simpson,D.M.; Katzenstein,D.; Shriver,S.; Hauer,P.; Brown,A.; Haidich,A.-B.; Moo,L.R.; McArthur,J.C.;. "Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy". Neurol. 2002; 58: 115-119.
Schifitto,G.; McDermott,M.P.; McArthur,J.C.; Marder,K.; Sacktor,N.; Epstein,L.; Kieburtz,K.; The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders;. "Incidence of and risk factors for HIV-associated distal sensory polyneuropathy". Neurol. 2002; 58: 1764-1768.
Vedhara,K.; McDermott,M.P.; Evans,T.; Treanor,J.; Plummer,S.; Tallon,D.; Chen,D.; Cruttenden,K.; Schifitto,G.;. "Chronic stress in non-elderly caregivers: Psychological, endocrine and immune implications". J Psychosomatic Research. 2002; 53: 1153-1161.
2001 Nov 9
Simpson DM, Katzenstein D, Haidich B, Millington D, Yiannoutsos C, Schifitto G, McArthur J, . "Plasma carnitine in HIV-associated neuropathy." AIDS. 2001 Nov 9; 15(16):2207-8.
2001 Aug
Huntington Study Group. "A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease". Neurology. 2001; 57(3): 397-404.
2001 Mar
Stern Y, McDermott MP, Albert S, Palumbo D, Selnes OA, McArthur J, Sacktor N, Schifitto G, Kieburtz K, Epstein L, Marder KS, . "Factors associated with incident human immunodeficiency virus-dementia." Archives of neurology. 2001 Mar; 58(3):473-9.
Schifitto,G.; Kieburtz,K.; McDermott,M.P.; McArthur,J.; Marder,K.; Sacktor,N.; Palumbo,D.; Selnes,O.; Stern,Y.; Epstein,L.; Albert,S.;. "Clinical trials in HIV-associated cognitive impairment: Cognitive and functional outcomes". Neurol. 2001; 56: 415-418.
Schifitto,G.; Yiannoutsos,C.; Simpson,D.M.; Adornato,B.T.; Singer,E.J.; Hollander,H.; Marra,C.M.; Rubin,M.; Cohen,B.A.; Tucker,T.; Koralnik,I.J.; Katzenstein,D.; Haidich,B.; Smith,M.E.; Shriver,S.; Millar,L.; Clifford,D.B.; McArthur,J.C.; the AIDS Clinical Trials Group Team 291;. "Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy". Neurol. 2001; 57: 1313-1316.
2000 Jul
Schifitto G, McDermott MP, Evans T, Fitzgerald T, Schwimmer J, Demeter L, Kieburtz K. "Autonomic performance and dehydroepiandrosterone sulfate levels in HIV-1-infected individuals: relationship to TH1 and TH2 cytokine profile." Archives of neurology. 2000 Jul; 57(7):1027-32.
2000 Mar 14
McArthur JC, Yiannoutsos C, Simpson DM, Adornato BT, Singer EJ, Hollander H, Marra C, Rubin M, Cohen BA, Tucker T, Navia BA, Schifitto G, Katzenstein D, Rask C, Zaborski L, Smith ME, Shriver S, Millar L, Clifford DB, Karalnik IJ. "A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291." Neurology. 2000 Mar 14; 54(5):1080-8.
Sacktor,N.; Schifitto,G.; McDermott,M.P.; Marder,K.; McArthur,J.C.; Kieburtz,K.;. "Transdermal selegiline in HIV-associated cognitive impairment: pilot placebo-controlled study". Neurol. 2000; 54: 233-235.
1999 Jul 22
Schifitto G, Sacktor N, Marder K, McDermott MP, McArthur JC, Kieburtz K, Small S, Epstein LG. "Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium." Neurology. 1999 Jul 22; 53(2):391-6.
Vedhara K, Schifitto G, McDermott M. "Disease progression in HIV-positive women with moderate to severe immunosuppression: the role of depression. Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders." Behavioral medicine (Washington, D.C.). 1999 25(1):43-7.
Schifitto G, Holloway R. "Cerebrovascular disease in patients with HIV-1 associated pulmonary hypertension." Journal of neuro-AIDS. 1999 2(2):57-64.
1998 Dec
Kieburtz K, Simpson D, Yiannoutsos C, Max MB, Hall CD, Ellis RJ, Marra CM, McKendall R, Singer E, Dal Pan GJ, Clifford DB, Tucker T, Cohen B. "A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team." Neurology. 1998 Dec; 51(6):1682-8.
1998 Mar
Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. "A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment". Neurology. 1998; 50(3): 645-51.
Berg,M.J.; Schifitto,G.; Powers,J.M.; Martinez-Capolino,C.; Fong,C.-T.; Myers,G.J.; Epstein,L.G.; Walsh,C.A.;. "X-linked female band heterotopia-male lissencephaly syndrome". Neurol. 1998; 50: 1143-1146.
1997 Aug
Schifitto G, Barbano RL, Kieburtz KD, Cohn SE, Zwillich SH. "HIV related vasculitic mononeuropathy multiplex: a role for IVIg?" Journal of neurology, neurosurgery, and psychiatry. 1997 Aug; 63(2):255-6.
1997 Jul
The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. "Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment". Neurology. 1997; 49(1): 142-6.
1996 Nov
The Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders. "Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder". Neurology. 1996; 47(5): 1247-53.


Schifitto G, Gaugh MD. "Human Immunodeficiency Virus-Associated Cognitive Impairment". Handbook of Neurologic Rating Scales. R. M. Herndon. : Demos Medical Publishing, 2006.
Schifitto G, Mariuz P.. "HIV-1-Associated Dementia (HAD)". Handbook of Secondary Dementias. R. Kurlan, MD. : Taylor & Francis, 2006.
Herrmann D, Schifitto G.. "HIV-Associated Neuropathy and Myelopathy". Principles of Neurologic Infectious Diseases. K. Roos, MD. : McGraw-Hill, 2005.
Schifitto G, Holloway R, Mariuz P, Kieburtz K.. "Neurological Complications Associated with HIV-1 Infection". Baker's Clinical Neurology. RJ Joynt MD, PhD and RC Griggs MD. : Lippincott-Raven, 2003.
Holloway R, Kieburtz K, and Schifitto G. "HIV-1 Infection and the Nervous System". Clinical Neurology. RJ Joynt, MD, PhD and RC Griggs, MD. : Lippincott-Raven, 1996. 1-45