Mark Edward Mapstone, Ph.D.

Mark Edward Mapstone, Ph.D.

Contact Information

University of California - Irvine
Sprague Hall, Room 318
839 Health Sciences Road
Irvine, CA 92697-3095

Office: (585) 273-4859
Fax: (585) 276-2207

Research Bio

Dr. Mapstone studies cognitive function in health and disease. His research addresses mechanisms of cognitive impairment in neurodegenerative diseases such as Alzheimer's and Parkinson's disease and ways to detect these cognitive changes as early in the course of the disease as possible.

His current work in this area focuses on blood based and electrophysiological biomarker discovery for Alzheimer's and Parkinson's diseases. His research also addresses cognitive effects of treatment for neurological diseases such as deep brain stimulation, stem cell therapy and cognitive training. Dr. Mapstone is a clinical neuropsychologist and his research is integrated into his clinical work.

Awards & Honors (Local)

Excellence in Research Incentive Program Award, University of Rochester 2006
Distinguished Delta Chi Award, The Delta Chi National Fraternity 2005
John Henry Hobart Fellow in Ethics and Social Justice, Hobart College 2004
Keynote Speaker, Charter Day Awards Ceremony, Hobart College 2004
NIH Fellowship, University of Rochester Medical Center 2001
George Yacorzinski Scholar, Northwestern University Medical School 2000
University Scholar, The Graduate School, Northwestern University 1996 - 1999
Merit Award, Department of Brain and Cognitive Sciences, MIT 1993
Psi Chi, National Honor Society in Psychology 1990
Dean's List Hobart College 1988 - 1989


Predicting Cognitive Decline in the Elderly Using Multimodal Neuropsychological Testing and Blood Plasma Lipidomic Profiling

United States Serial NO.: 15/134,976
Filed Date: April 21, 2016
Title: Biomarkers for Memory Loss
Invented by: Mark Mapstone, Howard Federoff, Amrita Cheema, Massimo Fiandaca

Recent Journal Articles

Showing the 5 most recent journal articles. 39 available »

2015 Apr 16
Chapman RM, Gardner MN, Mapstone M, Dupree HM, Antonsdottir IM. "Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage." Brain research. 2015 Apr 16; 1604:74-83. Epub 2015 Jan 30.
2014 Nov
Lin F, Heffner K, Mapstone M, Chen DG, Porsteisson A. "Frequency of mentally stimulating activities modifies the relationship between cardiovascular reactivity and executive function in old age." The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2014 Nov; 22(11):1210-21. Epub 2013 Jul 23.
2014 Jun
Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. "The critical need for defining preclinical biomarkers in Alzheimer's disease." Alzheimer's & dementia : the journal of the Alzheimer's Association. 2014 Jun; 10(3 Suppl):S196-212.
2014 May
Lin F, Lo RY, Cole D, Ducharme S, Chen DG, Mapstone M, Porsteinsson A, . "Longitudinal effects of metabolic syndrome on Alzheimer and vascular related brain pathology." Dementia and geriatric cognitive disorders extra. 2014 May; 4(2):184-94. Epub 2014 Jun 28.
2014 Apr
Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, Macarthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. "Plasma phospholipids identify antecedent memory impairment in older adults." Nature medicine. 2014 Apr; 20(4):415-8. Epub 2014 Mar 09.


PhD | Clinical Psychology | Northwestern University The Feinberg School of Medicine2000
MA | Psychology | Boston University1990
Louis Lowy Certificate | Gerontology | Boston University1990
BS | Psychology | Hobart and William Smith Colleges1989

Post-Doctoral Training & Residency

Fellowship in Clinical Neuropsychology and Experimental Therapeutics of Neurological Disease, Department of Neurology, University of Rochester Medical Center, Rochester, NY 2002
Internship in Clinical Psychology, Department of Psychology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 2000