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Charles J. Duffy, M.D., Ph.D.

Neurology

Clinical Interests

Memory Care

Contact Information

Phone Numbers

Appointment: (585) 275-1200

Office: (585) 760-6221

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Professional Background

Functioning of cerebral neocortex, using neurophysiologic and psychophysical methods to examine mechanisms of spatial orientation. Our ongoing studies combine optic flow visual displays with real translational movement of the monkey using a room-sized, motorized sled. These studies are directed at characterizing the neuronal mechanisms of self-movement perception.

Our human psychophysical studies are directed at analyzing the cortical operations involved in optic flow field perception. We are focusing on studies of perceptual involvement in the syndrome of visuospatial disorientation in Alzheimer's disease and other neurodegenerative disorders.

Research

Functioning of cerebral neocortex, using neurophysiologic and psychophysical methods to examine mechanisms of spatial orientation.

Single neuron recordings from awake monkey cerebral cortex have demonstrated the existence of neurons which are specifically activated during the viewing of optic flow fields. Our ongoing studies combine optic flow visual displays with real translational movement of the monkey using a room-sized, motorized sled. These studies are directed at characterizing the neuronal mechanisms of self-movement perception.

Our human psychophysical studies are directed at analyzing the cortical operations involved in optic flow field perception. We are focusing on studies of perceptual involvement in the syndrome of visuospatial disorientation in Alzheimer's disease and other neurodegenerative disorders.

Credentials

Faculty Appointments

Specialties

  • Neurology - American Board of Psychiatry and Neurology

Education

1984
PhD | Johns Hopkins U Sch Medicine
Physiology

1984
MD | Johns Hopkins U Sch Medicine
Physiology

1973
BA | Harvard University
Psychology

Post-doctoral Training & Residency

07/01/1984 - 06/30/1985
Internship in Internal Medicine at John Hopkins Univeristy School of Hygiene and Public Health

07/01/1985 - 06/30/1988
Residency in Neurology at Massachusetts General Hospital

07/01/1988 - 11/30/1993
Fellowship in Neurology: Clinical Neurophysiology at National Institute of Health

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Awards

1995
Sloan Foundation Fellowship, Alfred P. Sloan Foundation.

1983
Roland P. MacKay Award, 22nd Essay Contest, American Academy of Neurology.

1974
William Martin Cabot Honorary Scholarship, Harvard College, Cambridge, MA.

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Publications

Journal Articles

12/9/2015
Jacob MS, Duffy CJ. "Steering Transforms the Cortical Representation of Self-Movement from Direction to Destination." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 Dec 9; 35(49):16055-63.

3/15/2015
Page WK, Sato N, Froehler MT, Vaughn W, Duffy CJ. "Navigational path integration by cortical neurons: origins in higher-order direction selectivity." Journal of neurophysiology.. 2015 Mar 15; 113(6):1896-906. Epub 2015 Jan 14.

1/2015
Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, Holtzer R, Hyman BT, Lin FR, McKee AC, Morris JC, Petersen RC, Silbert LC, Struble RG, Trojanowski JQ, Verghese J, Wilson DA, Xu S, Zhang LI. "At the interface of sensory and motor dysfunctions and Alzheimer's disease." Alzheimer's & dementia : the journal of the Alzheimer's Association.. 2015 Jan 0; 11(1):70-98. Epub 2014 Jul 09.

Books & Chapters

1984
Chapter Title: Looking and Seeing: The Visual Functions of the Parietal Lobe
Book Title: Dynamic Aspects of Neocortical
Author List: Mountcastle, V.B.; Motter, B.C.; Steinmetz, M.A.; Duffy, C.J.
Edited By: G.M. Edelman; W.E. Gall; W.M. Cowan
Published By: Wiley and Sons1984

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