Charles J. Duffy, M.D., Ph.D.

Charles J. Duffy, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 673
Rochester, NY 14642

Office: (585) 760-6221

Professional Bio

Functioning of cerebral neocortex, using neurophysiologic and psychophysical methods to examine mechanisms of spatial orientation. Our ongoing studies combine optic flow visual displays with real translational movement of the monkey using a room-sized, motorized sled. These studies are directed at characterizing the neuronal mechanisms of self-movement perception.



Our human psychophysical studies are directed at analyzing the cortical operations involved in optic flow field perception. We are focusing on studies of perceptual involvement in the syndrome of visuospatial disorientation in Alzheimer's disease and other neurodegenerative disorders.

Research Bio

Functioning of cerebral neocortex, using neurophysiologic and psychophysical methods to examine mechanisms of spatial orientation.



Single neuron recordings from awake monkey cerebral cortex have demonstrated the existence of neurons which are specifically activated during the viewing of optic flow fields. Our ongoing studies combine optic flow visual displays with real translational movement of the monkey using a room-sized, motorized sled. These studies are directed at characterizing the neuronal mechanisms of self-movement perception.

Our human psychophysical studies are directed at analyzing the cortical operations involved in optic flow field perception. We are focusing on studies of perceptual involvement in the syndrome of visuospatial disorientation in Alzheimer's disease and other neurodegenerative disorders.

Awards & Honors (Local)

Sloan Foundation Fellowship, Alfred P. Sloan Foundation. 1995
Roland P. MacKay Award, 22nd Essay Contest, American Academy of Neurology. 1983
William Martin Cabot Honorary Scholarship, Harvard College, Cambridge, MA. 1974

Recent Journal Articles

Showing the 5 most recent journal articles. 70 available »

2015 Mar 15
Page WK, Sato N, Froehler MT, Vaughn W, Duffy CJ. "Navigational path integration by cortical neurons: origins in higher-order direction selectivity." Journal of neurophysiology. 2015 Mar 15; 113(6):1896-906. Epub 2015 Jan 14.
2015 Jan
Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, Holtzer R, Hyman BT, Lin FR, McKee AC, Morris JC, Petersen RC, Silbert LC, Struble RG, Trojanowski JQ, Verghese J, Wilson DA, Xu S, Zhang LI. "At the interface of sensory and motor dysfunctions and Alzheimer's disease." Alzheimer's & dementia : the journal of the Alzheimer's Association. 2015 Jan; 11(1):70-98. Epub 2014 Jul 09.
2015
Jacob MS, Duffy CJ. "Steering Transforms the Cortical Representation of Self-Movement from Direction to Destination." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 35(49):16055-63.
2014
Jacob MS, Duffy CJ. "Might cortical hyper-responsiveness in aging contribute to Alzheimer's disease?" PloS one. 2014 9(9):e105962. Epub 2014 Sep 10.
2013 Jan
Sato N, Page WK, Duffy CJ. "Task contingencies and perceptual strategies shape behavioral effects on neuronal response profiles." Journal of neurophysiology. 2013 Jan; 109(2):546-56. Epub 2012 Oct 24.

Current Appointments

Professor - Department of Neurology, Cognitive Behavioral Neurology (SMD) - Primary
Professor - Department of Neuroscience (SMD)
Professor - Center for Visual Science A&S (RC)

Specialties

Neurology - American Board of Psychiatry and Neurology

Education

PhD | Physiology | Johns Hopkins U Sch Medicine1984
MD | Physiology | Johns Hopkins U Sch Medicine1984
BA | Psychology | Harvard University1973

Post-Doctoral Training & Residency

Fellowship in Neurophysiology at National Institute of Health07/01/1988 - 11/30/1993
Residency in Neurology at Massachusetts General Hospital07/01/1985 - 06/30/1988
Internship in Internal Medicine at John Hopkins Univeristy School of Hygiene and Public Health07/01/1984 - 06/30/1985