Charles Joseph Duffy, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 275-1200

Office: (585) 760-6221

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 673
Rochester, NY 14642

Biography

Professional Background

Functioning of cerebral neocortex, using neurophysiologic and psychophysical methods to examine mechanisms of spatial orientation. Our ongoing studies combine optic flow visual displays with real translational movement of the monkey using a room-sized, motorized sled. These studies are directed at characterizing the neuronal mechanisms of self-movement perception.

Our human psychophysical studies are directed at analyzing the cortical operations involved in optic flow field perception. We are focusing on studies of perceptual involvement in the syndrome of visuospatial disorientation in Alzheimer's disease and other neurodegenerative disorders.

Research

Functioning of cerebral neocortex, using neurophysiologic and psychophysical methods to examine mechanisms of spatial orientation.

Single neuron recordings from awake monkey cerebral cortex have demonstrated the existence of neurons which are specifically activated during the viewing of optic flow fields. Our ongoing studies combine optic flow visual displays with real translational movement of the monkey using a room-sized, motorized sled. These studies are directed at characterizing the neuronal mechanisms of self-movement perception.

Our human psychophysical studies are directed at analyzing the cortical operations involved in optic flow field perception. We are focusing on studies of perceptual involvement in the syndrome of visuospatial disorientation in Alzheimer's disease and other neurodegenerative disorders.

Credentials

Education

1973
BA | Harvard University
Psychology

1984
PhD | Johns Hopkins U Sch Medicine
Physiology

1984
MD | Johns Hopkins U Sch Medicine
Physiology

Post-doctoral Training & Residency

07/01/1988 - 11/30/1993
Fellowship in Clinical Neurophysiology at National Institutes of Health, NIH

07/01/1985 - 06/30/1988
Residency in Neurology at Massachusetts General Hospital

07/01/1984 - 06/30/1985
Internship in Internal Medicine at Johns Hopkins Bloomberg School of Public Health

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Awards

1995
Sloan Foundation Fellowship, Alfred P. Sloan Foundation.

1983
Roland P. MacKay Award, 22nd Essay Contest, American Academy of Neurology.

1974
William Martin Cabot Honorary Scholarship, Harvard College, Cambridge, MA.

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Publications

Journal Articles

1/1/2018
Page WK, Duffy CJ. "Path perturbation detection tasks reduce MSTd neuronal self-movement heading responses." Journal of neurophysiology.. 2018 Jan 1; 119(1):124-133. Epub 2017 Oct 18.

12/9/2015
Jacob MS, Duffy CJ. "Steering Transforms the Cortical Representation of Self-Movement from Direction to Destination." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 Dec 9; 35(49):16055-63.

3/15/2015
Page WK, Sato N, Froehler MT, Vaughn W, Duffy CJ. "Navigational path integration by cortical neurons: origins in higher-order direction selectivity." Journal of neurophysiology.. 2015 Mar 15; 113(6):1896-906. Epub 2015 Jan 14.

Books & Chapters

1984
Chapter Title: Looking and Seeing: The Visual Functions of the Parietal Lobe
Book Title: Dynamic Aspects of Neocortical
Author List: Mountcastle, V.B.; Motter, B.C.; Steinmetz, M.A.; Duffy, C.J.
Edited By: G.M. Edelman; W.E. Gall; W.M. Cowan
Published By: Wiley and Sons 1984

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