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Alan V. Smrcka, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 275-1681

Research Labs

Biography

Research

G protein coupled receptors (GPCRs) form a large family of cell surface receptors responsible for triggering cellular responses to a variety of extracellular stimuli including drugs such as opiates, and hormones such as adrenaline, serotonin or acetylcholine. All GPCRs function through activation of trimeric G proteins located on the inner surface of the plasma membrane. Activated G proteins target ion channels or enzymes that produce second messengers with a variety of effects depending on the type of cell that is stimulated. Examples include regulation of synaptic transmission in the central nervous system, chemotaxis in the immune system, and vascular remodeling in the cardiovascular system. This family of receptors is an important target for pharmaceuticals and defects in GPCR systems are responsible for a number of diseases.

Our laboratory focuses on analysis of the interactions between the G proteins and their protein targets at a molecular and structural level with the goal of understanding how these interactions lead to alterations in protein and cellular activities. Another goal is to connect the biochemical information about protein interaction interfaces to specific cellular physiologies. To this end we are developing antagonists of specific G protein interactions and using these tools to probe the functions of those interactions in living cells. This approach will help to define the roles of specific G protein interactions in physiological processes and as potential targets for therapeutic intervention in cardiovascular disease or cancer.

Credentials

Education

1990
PhD | University of Arizona
Biochemistry

1984
MS | Arizona State University
Botany

1981
BS | University of Connecticut
Biology

Awards

2007
Davey Award
Sponsor: URMC Cancer Center

Publications

Journal Articles

9/2016
Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH. "Inhibition of G Protein ?? Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice." Arthritis & rheumatology.. 2016 Sep 0; 68(9):2244-56.

9/2016
Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. "Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist." Molecular pharmacology.. 2016 Sep 0; 90(3):214-24. Epub 2016 Jun 23.

2/23/2016
Surve CR, To JY, Malik S, Kim M, Smrcka AV. "Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits G?i-GTP and G??." Science signaling. 2016 Feb 23; 9(416):ra22. Epub 2016 Feb 23.

Books & Chapters

2004
Book Title: G Protein signaling: Methods and Protocols
Author List: Alan V. Smrcka editor
Edited By: Alan V. Smrcka
Published By: Humana Press2004 in Totowa, NJ

2004
Chapter Title: Assay for G Protein Dependent Activation of Phospholipase C beta Using Purified Protein Components
Book Title: G Protein signaling: Methods and Protocols
Author List: Ghosh, M. and Smrcka, A.V.
Edited By: Alan V. Smrcka
Published By: Humana Press2004 in Totowa, NJ

2004
Chapter Title: Purification of Phospholipase C beta and Phospholipase C epsilon from Sf9 cells
Book Title: G Protein signaling: Methods and Protocols
Author List: Ghosh, M., Wang, H., Kelley, G.G., and Smrcka, A.V.
Edited By: Alan V. Smrcka
Published By: Humana Press2004 in Totowa, NJ

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