Alan V. Smrcka, Ph.D.

Alan V. Smrcka, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-0892
Lab: (585) 275-0859
Fax: (585) 273-2652

Research Bio

G protein coupled receptors (GPCRs) form a large family of cell surface receptors responsible for triggering cellular responses to a variety of extracellular stimuli including drugs such as opiates, and hormones such as adrenaline, serotonin or acetylcholine. All GPCRs function through activation of trimeric G proteins located on the inner surface of the plasma membrane. Activated G proteins target ion channels or enzymes that produce second messengers with a variety of effects depending on the type of cell that is stimulated. Examples include regulation of synaptic transmission in the central nervous system, chemotaxis in the immune system, and vascular remodeling in the cardiovascular system. This family of receptors is an important target for pharmaceuticals and defects in GPCR systems are responsible for a number of diseases.

Our laboratory focuses on analysis of the interactions between the G proteins and their protein targets at a molecular and structural level with the goal of understanding how these interactions lead to alterations in protein and cellular activities. Another goal is to connect the biochemical information about protein interaction interfaces to specific cellular physiologies. To this end we are developing antagonists of specific G protein interactions and using these tools to probe the functions of those interactions in living cells. This approach will help to define the roles of specific G protein interactions in physiological processes and as potential targets for therapeutic intervention in cardiovascular disease or cancer.

Awards & Honors (Local)

Davey Award | URMC Cancer Center 2007


Pharmacological Manipulation of G Protein [Beta gamma] Subunit Signaling

United States Serial NO.: 11/885,981
Filed Date: March 7, 2006
Title: Compositions and Methods for Inhibiting G Protein Signaling
Invented by: Alan Smrcka, Jose Font, Tabetha Bonacci
Pharmacological Manipulation of G Protein [Beta gamma] Subunit Signaling

United States Serial NO.: 13/630,995
Filed Date: September 28, 2012
Title: Methods for Treating Opioid Tolerance
Invented by: Alan Smrcka, Jose Font, Tabetha Bonacci
Small Molecule Targeting of G-Protein Beta Gamma in Cardiovascular Disease, Including Hypertension, Vascular Injury/Restenosis, and Atherosclerosis

United States Serial NO.: 12/597,509
Filed Date: April 28, 2008
Title: Compositions and Methods for Inhibiting G Protein Signaling
Invented by: Burns Blaxall, Alan Smrcka, Jean Bidlack

Recent Journal Articles

Showing the 5 most recent journal articles. 100 available »

2016 Sep
Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH. "Inhibition of G Protein ?? Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice." Arthritis & rheumatology. 2016 Sep; 68(9):2244-56.
2016 Sep
Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. "Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist." Molecular pharmacology. 2016 Sep; 90(3):214-24. Epub 2016 Jun 23.
2016 Feb 23
Surve CR, To JY, Malik S, Kim M, Smrcka AV. "Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits G?i-GTP and G??." Science signaling. 2016 Feb 23; 9(416):ra22. Epub 2016 Feb 23.
2015 Dec 1
Smrcka AV. "Fingerprinting G protein-coupled receptor signaling." Science signaling. 2015 Dec 1; 8(405):fs20. Epub 2015 Dec 01.
2015 Oct
Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW. "Adenylyl Cyclase 5 Regulation by G?? Involves Isoform-Specific Use of Multiple Interaction Sites." Molecular pharmacology. 2015 Oct; 88(4):758-67. Epub 2015 Jul 23.


PhD | Biochemistry | University of Arizona1990
MS | Botany | Arizona State University1984
BS | Biology | University of Connecticut1981

Post-Doctoral Training & Residency

Postdoctoral Fellow, Pharmacology Department, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, laboratory of Dr. Paul C. Sternweis 1994