Robert A. Gross, M.D., Ph.D.

Robert A. Gross, M.D., Ph.D.

Contact Information

919 Westfall Rd, Clinton Crossings Bldg C, Suite 220
Rochester, NY 14618

Fax: (585) 756-2311
Administrative: (585) 275-6412
Office: (585) 275-6412

Journal Articles

Showing all 79 journal articles available.

2016 Oct 18
Auerbach DS, McNitt S, Gross RA, Zareba W, Dirksen RT, Moss AJ. "Genetic biomarkers for the risk of seizures in long QT syndrome." Neurology. 2016 Oct 18; 87(16):1660-1668. Epub 2016 Jul 27.
2016 Sep 6
Gross RA. "Designing the reader's journal." Neurology. 2016 Sep 6; 87(10):962-9.
2016 Sep
Janelsins MC, Heckler CE, Thompson BD, Gross RA, Opanashuk LA, Cory-Slechta DA. "A clinically relevant dose of cyclophosphamide chemotherapy impairs memory performance on the delayed spatial alternation task that is sustained over time as mice age." Neurotoxicology. 2016 Sep; 56:287-293. Epub 2016 Jun 28.
2016 Jul 5
Baskin PK, Gross RA. "Contemplations on an unfolding future: Journal designs and standards." Neurology. 2016 Jul 5; 87(1):11-2.
2016 May 10
Gyang TV, Hamel J, Goodman AD, Gross RA, Samkoff L. "Fingolimod-associated PML in a patient with prior immunosuppression." Neurology. 2016 May 10; 86(19):1843-5. Epub 2016 Apr 13.
2016 Jan 5
Baskin PK, Gross RA. "Neurology mini-sites: New content and re-use of previously published Neurology content." Neurology. 2016 Jan 5; 86(1):11-2.
2015 Jul 7
Gross RA. "Style, spin, and science." Neurology. 2015 Jul 7; 85(1):10-1.
2015 Apr
Gewandter JS, Smith SM, McKeown A, Edwards K, Narula A, Pawlowski JR, Rothstein D, Desjardins PJ, Dworkin SF, Gross RA, Ohrbach R, Rappaport BA, Sessle BJ, Turk DC, Dworkin RH. "Reporting of adverse events and statistical details of efficacy estimates in randomized clinical trials of pain in temporomandibular disorders: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review." The Journal of the American Dental Association. 2015 Apr; 146(4):246-54.e6.
2015 Jan 6
Baskin PK, Gross RA. "Tools for readers: Getting the most from the Neurology electronic platforms." Neurology. 2015 Jan 6; 84(1):11-2.
2015 Jan
Gewandter JS, McKeown A, McDermott MP, Dworkin JD, Smith SM, Gross RA, Hunsinger M, Lin AH, Rappaport BA, Rice AS, Rowbotham MC, Williams MR, Turk DC, Dworkin RH. "Data interpretation in analgesic clinical trials with statistically nonsignificant primary analyses: an ACTTION systematic review." The journal of pain : official journal of the American Pain Society. 2015 Jan; 16(1):3-10. Epub 2014 Oct 23.
2014 Jul 11
Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS. "Molecular and functional identification of a mitochondrial ryanodine receptor in neurons." Neuroscience letters. 2014 Jul 11; 575:7-12. Epub 2014 May 23.
2014 Jun
Hunsinger M, Smith SM, McKeown A, Parkhurst M, Gross RA, Lin AH, McDermott MP, Rappaport BA, Turk DC, Dworkin RH. "Disclosure of authorship contributions in analgesic clinical trials and related publications: ACTTION systematic review and recommendations." Pain. 2014 Jun; 155(6):1059-63. Epub 2013 Dec 12.
2014 Jan 7
Knopman DK, Gross RA. "A call for "negative" outcome studies." Neurology. 2014 Jan 7; 82(1):11-2.
2013 Apr 30
Brenner SR, Calamante F, Gross RA. "Mouse brain kaleidoscope." Neurology. 2013 Apr 30; 80(18):1720.
2013 Mar
Pereira A, Gitlin MJ, Gross RA, Posner K, Dworkin RH. "Suicidality associated with antiepileptic drugs: implications for the treatment of neuropathic pain and fibromyalgia." Pain. 2013 Mar; 154(3):345-9. Epub 2013 Jan 11.
2012 Oct 11
Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. "A call for transparent reporting to optimize the predictive value of preclinical research." Nature. 2012 Oct 11; 490(7419):187-91.
2011 Oct 25
Baskin PK, Gross RA. "Honorary and ghost authorship." BMJ : British medical journal. 2011 Oct 25; 343:d6223. Epub 2011 Oct 25.
Digiovanni BF, Ward DS, O'Donnell SM, Fong CT, Gross RA, Grady-Weliky T, Lambert DR. "Process of discovery: a fourth-year translational science course." Medical education online. 2011 16Epub 2011 Dec 05.
2010 Jul 6
Gross RA. "Three flasks." Neurology. 2010 Jul 6; 75(1):92.
2010 Jun
Janelsins MC, Roscoe JA, Berg MJ, Thompson BD, Gallagher MJ, Morrow GR, Heckler CE, Jean-Pierre P, Opanashuk LA, Gross RA. "IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice." Cancer investigation. 2010 Jun; 28(5):544-53.
2010 Feb
Baskin PK, Knopman DS, Gross RA. "Conflicts of interest, authorship, and disclosures in industry-related scientific publications." Mayo Clinic proceedings. 2010 Feb; 85(2):196-7; author 201-4.
2010 Jan 5
Gross RA. "Mission: neurology(r)." Neurology. 2010 Jan 5; 74(1):10-2.
2009 Jan 6
Gross RA, Johnston KC. "Levels of evidence: Taking Neurology to the next level." Neurology. 2009 Jan 6; 72(1):8-10.
2008 Dec 2
Noseworthy JH, Gross RA. "Citation and readership metrics: how does Neurology measure up?" Neurology. 2008 Dec 2; 71(23):1846-7.
2008 Nov
Berg MJ, Gross RA, Haskins LS, Zingaro WM, Tomaszewski KJ. "Generic substitution in the treatment of epilepsy: patient and physician perceptions." Epilepsy & behavior : E&B. 2008 Nov; 13(4):693-9. Epub 2008 Sep 10.
2008 Jul 22
Noseworthy JH, Gross RA, Engel AG, Johnston KC, Knopman DS, Mink JW, Ransohoff RM, Uitti RJ. "Translating research into treatments." Neurology. 2008 Jul 22; 71(4):232-3. Epub 2008 Jun 04.
2007 Dec 15
Duan Y, Gross RA, Sheu SS. "Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity." The Journal of physiology. 2007 Dec 15; 585(Pt 3):741-58. Epub 2007 Oct 18.
2005 Aug 23
Gross RA. "The profusion of genotypes and phenotypes in "idiopathic" generalized epilepsies." Neurology. 2005 Aug 23; 65(4):503.
2005 Feb 8
Beydoun A, Uthman BM, Kugler AR, Greiner MJ, Knapp LE, Garofalo EA, . "Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy." Neurology. 2005 Feb 8; 64(3):475-80.
Schwid SR, Gross RA, Mink JW and Griggs RC. "(Editorial Comment on Cody C. Eiberg, Ilo E. Leppik, Reed Perron, Ilo E. Leppik, James C. Clyod III, Lower Phenytoin serum levels in persons switched from brand to generic pheytoin)." Neurology. 2005; 64: 1485-1486.
Schwid SR and Gross RA. "Bias, not conflict of interest, is the enemy. (Editorial)." Neurology. 2005; 64: 1830-1831.
2004 Jun 8
Gross RA, Gidal BE, Pack AM. "Patient page. Antiseizure drugs and reduced bone density." Neurology. 2004 Jun 8; 62(11):E24-5.
2003 Oct 14
Takahashi Y, Mori H, Mishina M, Watanabe M, Fujiwara T, Shimomura J, Aiba H, Miyajima T, Saito Y, Nezu A, Nishida H, Imai K, Sakaguchi N, Kondo N. "Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua." Neurology. 2003 Oct 14; 61(7):891-6.
2003 Apr 8
Lagerlund TD, Gross RA. "DC-EEG recording: a paradigm shift in seizure localization?" Neurology. 2003 Apr 8; 60(7):1062-3.
2003 Jan
Ferland RJ, Williams JP, Gross RA, Applegate CD. "The effects of brain-irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J mice." Experimental neurology. 2003 Jan; 179(1):71-82.
Ferland RJ, William JP, Gross RA and Applegate CD. "The effects of brain irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J." Experimental Neurology. 2003; 64: 71-82.
2002 Oct 31
Ferland RJ, Gross RA, Applegate CD. "Differences in hippocampal mitotic activity within the dorsal and ventral hippocampus following flurothyl seizures in mice." Neuroscience letters. 2002 Oct 31; 332(2):131-5.
2002 Feb
Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. "Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation." Journal of neurochemistry. 2002 Feb; 80(3):531-8.
Ferland RJ, Gross RA, Applegate CD. "Increased mitotic activity in the dentate gyrus of the hippocampus of adult C57BL/6J mice exposed to the flurothyl kindling model of epileptogenesis." Neuroscience. 2002 115(3):669-83.
2001 Feb 15
Scott JK, Huang SF, Gangadhar BP, Samoriski GM, Clapp P, Gross RA, Taussig R, Smrcka AV. "Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors." The EMBO journal. 2001 Feb 15; 20(4):767-76.
Gross RA. "Advances in Neurology, vol. 84: Neocortical Epilepsies, by P. D. Williamson et al. (Book review)." Neurology. 2001; 56: 1251.
2000 Aug
Samoriski GM, Gross RA. "Functional compartmentalization of opioid desensitization in primary sensory neurons." The Journal of pharmacology and experimental therapeutics. 2000 Aug; 294(2):500-9.
Xie W., Samoriski G, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. "Genetic alteration of PLC B3 expression modulates behavioral and cellular Response to u opiods." Proceedings of the National academy of Sciences. 1999; 96: 10385-10390.
Gross RA and Theodore WH. ""The seat of the discharge" and the molecules that goven seizures> (Editorial)." Neruolgoy. 1999; 52: 441-443.
1998 May
Greene JG, Sheu SS, Gross RA, Greenamyre JT. "3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms." Neuroscience. 1998 May; 84(2):503-10.
Gross RA. "Epilepsy. A Comprehensive Testbook, by Engel & Pedley (book review)." Archives of Neurology. 1998; 55: 1373-1374.
Gross RA. "Epilepsy. A Comprehensive Textbook, by Engel & Pedley (book review)." Archives of Neurology. 1998; 55: 1373-1374.
1997 Mar
Wiley JW, Moises HC, Gross RA, MacDonald RL. "Dynorphin A-mediated reduction in multiple calcium currents involves a G(o) alpha-subtype G protein in rat primary afferent neurons." Journal of neurophysiology. 1997 Mar; 77(3):1338-48.
1997 Feb
Gross RA, Covey DF, Ferrendelli JA. "Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones." The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):686-94.
1994 Aug
Gross RA, Huggenvik J, Massa E, Allen RG, Uhler MD. "Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells." Molecular endocrinology. 1994 Aug; 8(8):970-82.
Gross RA. "Seized, by Eve LaPlante (book review)." Neurology. 1994; 44: 2220-2221.
1993 Jul
Wiley JW, Gross RA, MacDonald RL. "Agonists for neuropeptide Y receptor subtypes NPY-1 and NPY-2 have opposite actions on rat nodose neuron calcium currents." Journal of neurophysiology. 1993 Jul; 70(1):324-30.
1992 Jul
Gross RA. "A brief history of epilepsy and its therapy in the Western Hemisphere." Epilepsy research. 1992 Jul; 12(2):65-74.
Wiley JW, Gross RA and Macdonald RL. "The peptide calcitonin gene-related peptide increase a high threshold Ca2+ current in rat nodose neurons via a pertussis toxin-sensitive pathway." Journal of Physiology (London). 1992; 455.
Gross RA. "Een korte geschiendenis van epilepsie en haar therapeutische benadering in het Westelijk Halfron (translation of number 26 above)." Acta Antwerpiensia. 1992; 9: 10-23.
Kelly KM, Gross RA and Macdonald RL. "Tetrahydroaminoacridine reduces voltage-dependent calcium currents in rat sensory neurons." Neuroscience Letters. 1991; 132: 367-381.
Gross, RA. "Vertigo: Its Multisensory Syndromes." The New England Journal of Medicine. 1991; 325: 1258.
1990 Dec 10
Gross RA, Uhler MD, Macdonald RL. "The reduction of neuronal calcium currents by ATP-gamma-S is mediated by a G protein and occurs independently of cyclic AMP-dependent protein kinase." Brain research. 1990 Dec 10; 535(2):214-20.
1990 Jun
Wiley JW, Gross RA, Lu YX, Macdonald RL. "Neuropeptide Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism." Journal of neurophysiology. 1990 Jun; 63(6):1499-507.
1990 Apr
Gross RA, Wiley JW, Ryan-Jastrow T, Macdonald RL. "Regulation by GTP and its stable thiol derivatives of calcium current components in rat nodose ganglion neurons." Molecular pharmacology. 1990 Apr; 37(4):546-53.
Gross RA, Moises HC, Uhler MD and Macdonald RL. "Valproic acid selectively reudces the low-threshold (T) calcium current in rat nodose neurons." Proceedings of the National academy of Sciences USA. 1990; 87: 7025-7029.
Gross RA, Uhler MD and Macdonald RL. "The cyclic AMP-dependent protein kinase catalytic subunit selectively enhances calcium currents in rat nodose neurones." Journal of Physiology (London). 1990; 429: 483-496.
1989 Jun
Gross RA, MacDonald RL. "Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner." Journal of neurophysiology. 1989 Jun; 61(6):1259-69.
1989 Jan
Gross RA, Macdonald RL. "Cyclic AMP selectively reduces the N-type calcium current component of mouse sensory neurons in culture by enhancing inactivation." Journal of neurophysiology. 1989 Jan; 61(1):97-105.
Gross RA, Macdonald RL and Ryan-Jastrow T. "2-chloroadenosine selectively reduces the N-type calcium current of mouse dorsal root ganglion neurones in a pertussis toxin sensitive manner." Journal of Physiology (London). 1989; 411: 585-595.
1988 May 16
Gross RA, Macdonald RL. "Reduction of the same calcium current component by A and C kinases: differential pertussis toxin sensitivity." Neuroscience letters. 1988 May 16; 88(1):50-6.
1988 Mar
Gross RA, Macdonald RL. "Barbiturates and nifedipine have different and selective effects on calcium currents of mouse DRG neurons in culture: a possible basis for differing clinical actions. The 1987 S. Weir Mitchell award." Neurology. 1988 Mar; 38(3):443-51.
1988 Mar
Gross RA, Herridge P. "A maniclike illness associated with right frontal arteriovenous malformation." The Journal of clinical psychiatry. 1988 Mar; 49(3):119-20.
Gross RA and Macdonald RL. "Differential actions of pentobarbitone on calcium current components of mouse sensory neurones in culture." Journal of Physiology (London). 1988; : 187-203.
Schwartz WJ, Gross RA and Morton MT. "The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker." Proceedings of the National Academy of Sciences USA. 1987; 84: 1694-1698.
Gross RA and Macdonald RL. "Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture." Proceedings of the National Academy of Sciences USA. 1987; 84: 5469-5473.
1986 Jun
Tyler KL, Gross RA, Cascino GD. "Unusual viral causes of transverse myelitis: hepatitis A virus and cytomegalovirus." Neurology. 1986 Jun; 36(6):855-8.
1984 Dec
Wechsler LR, Gross RA, Miller DC. "Meningeal gliomatosis with "negative" CSF cytology: the value of GFAP staining." Neurology. 1984 Dec; 34(12):1611-5.
1982 Jul
Gross RA, Ferrendelli JA. "Relationships between norepinephrine and cyclic nucleotides in brain and seizure activity." Neuropharmacology. 1982 Jul; 21(7):655-61.
1980 Oct 27
Ferrendelli JA, Blank AC, Gross RA. "Relationships between seizure activity and cyclic nucleotide levels in brain." Brain research. 1980 Oct 27; 200(1):93-103.
1980 May
Gross RA, Ferrendelli JA. "Mechanisms of cyclic AMP regulation in cerebral anoxia and their relationship to glycogenolysis." Journal of neurochemistry. 1980 May; 34(5):1309-18.
1979 Oct
Gross RA, Ferrendelli JA. "Effects of reserpine, propranolol, and aminophylline on seizure activity and CNS cyclic nucleotides." Annals of neurology. 1979 Oct; 6(4):296-301.
1977 Mar
Gross RA, Clark RB. "Regulation of adenosine 3',5'-monophosphate content in human astrocytoma cells by isoproterenol and carbachol." Molecular pharmacology. 1977 Mar; 13(2):242-50.
1974 Aug 25
Clark RB, Gross R, Su YF, Perkins JP. "Regulation of adenosine 3':5'-monophosphate content in human astrocytoma cells by adenosine and the adenine nucleotides." The Journal of biological chemistry. 1974 Aug 25; 249(16):5296-303.


Drew-Cates J and Gross RA.. ""Neurolgoic Disorders".". Pharmacotherapeutics. E.Q. Youngkin, K.J. Sawin, J.F. Kissinger and D.S. Israel, eds.. Stamford, CT.: Appleton & Lange, 1998. 621-682
Macdonald RL, Weddle MG and Gross RA.. ""Benzodiazepine, B-carboline and barbiturate actions on GABA responses".". GABAergic Transmission and Anxiety, Advances in Biochemical Psychopharmacology. G. Biggio and E. Costa, eds.. New York: Raven Press, 1986. 67-78
Gross RA and Ferrendelli JA.. ""Cerebral metabolism during seizures: Regulation and role of cyclic AMP in epileptic brain".". Cerebral Metabolism and Neural Function.. J.V. Passonneau et al., eds.. Baltimore: Williams and Wilkins, 1980.
Ferrendelli JA, Gross RA, Kinscherf DA and Rubin EH.. ""Effects of seizures and anticonvulsant drugs on cyclic nucleotide regulation in the CNS".". Neuropharmacology of Cyclic Nucleotides. G.C. Palmer, ed.. Baltimore: Urban and Schwarzenberg, 1979.