Skip to main content
Explore URMC

URMC Logo

menu

Michael A. O'Reilly, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5948

Office: (585) 275-5948

Research Labs

O'Reilly Lab

Lab: (585) 275-1450

Lab: (585) 273-4831

Lab: (585) 273-3118

Visit Lab Website

Biography

Research

Dr. O¹Reilly¹s laboratory investigates mechanisms controlling lung epithelial cell survival and differentiation in response to oxidative stress caused by exposure to high oxygen (hyperoxia). Although hyperoxia is often used to treat patients with respiratory distress, it stimulates cell death in adults and permanently disrupts lung development in neonates. Research in the laboratory focuses on two major lines of investigation. First, understand how hyperoxia activates the p53-dependent expression of the cell cycle inhibitor p21 and how p21 controls cell growth, survival, and inflammation. Second, understand how neonatal exposure to hyperoxia stimulates differentiation of alveolar epithelial progenitor cells and why this leads to long-term susceptibility to subsequent respiratory insults. These studies will allow us to develop novel therapies for treating patients requiring oxygen, as well as provide valuable information on other conditions involving persistent oxidative stress, including inflammation, neurodegeneration, cancer, and the aging process. Research funding comes from an NIH R01, the March of Dimes and participation in other NIH grants.

Credentials

Faculty Appointments

Education

1984
BS | SUNY at Stony Brook
Biology

1989
PhD | University of Cincinnati
Developmental Biology

Awards

2005
Ruth A. Lawrence Academic Faculty Service Award
Sponsor: Department of Pediatrics

2004 - 2008
Dean's Incentive Award
Location: University of Rochester Research

1993 - 1995
National Research Council
Sponsor: NICHD, NIH Research

1988 - 1989
Albert B. Ryan
Location: University of Cincinnati Ph.D Studies

1986 - 1988
NIH Training Grant
Location: University of Cincinnati

VIEW ALL expand_more

Publications

Journal Articles

11/1/2017
Domm W, Yee M, Misra RS, Gelein R, Nogales A, Martinez Sobrido L, O'Reilly MA. "Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus." American journal of physiology. Lung cellular and molecular physiology.. 2017 Nov 1; 313(5):L940-L949. Epub 2017 Aug 10.

4/2017
Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA. "Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells." American journal of respiratory cell and molecular biology.. 2017 Apr 0; 56(4):453-464.

3/2017
O'Reilly MA. "Giving New Identities to Alveolar Epithelial Type I Cells." American journal of respiratory cell and molecular biology.. 2017 Mar 0; 56(3):277-278.

Books & Chapters

2015
Chapter Title: Perinatal disruptions of lung development: Mechanisms and implications for chronic lung diseases.
Book Title: Lung Development, Clinical Correlates and Technologies for the Future
Author List: O'Reilly, MA.
Edited By: Whitsett J, Jobe A, and Abman, S
Published By: New York, Cambridge University Press2015

2014
Chapter Title: The impact of DNA damage on epithelial cell maintenance of the lung.
Book Title: Mitochondrial Function in Lung Health and Disease.
Author List: Kalifa L and O'Reilly MA.
Edited By: Natargajan V and Parinandi NL
Published By: Springer Science+Business Media2014

2005
Chapter Title: Cell and Animal Models of Lung Injury
Book Title: Lung Injury: Mechanisms, Pathophysiology, and Therapy
Author List: Finkelstein JN, O'Reilly MA, Holm BA, Chess PC, Notter RH
Published By: Marcel Dekker2005 in New York, NY

VIEW ALL PUBLICATIONS

Videos

play_circle_filled

Many 'Adult' Diseases Trace Back to Baby's Earliest Days