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Michael A. O'Reilly, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5948

Office: (585) 275-5948

Research Labs

O'Reilly Lab

Lab: (585) 275-1450

Lab: (585) 273-4831

Lab: (585) 273-3118

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Research Network

Biography

Research

Dr. O¹Reilly¹s laboratory investigates mechanisms controlling lung epithelial cell survival and differentiation in response to oxidative stress caused by exposure to high oxygen (hyperoxia). Although hyperoxia is often used to treat patients with respiratory distress, it stimulates cell death in adults and permanently disrupts lung development in neonates. Research in the laboratory focuses on two major lines of investigation. First, understand how hyperoxia activates the p53-dependent expression of the cell cycle inhibitor p21 and how p21 controls cell growth, survival, and inflammation. Second, understand how neonatal exposure to hyperoxia stimulates differentiation of alveolar epithelial progenitor cells and why this leads to long-term susceptibility to subsequent respiratory insults. These studies will allow us to develop novel therapies for treating patients requiring oxygen, as well as provide valuable information on other conditions involving persistent oxidative stress, including inflammation, neurodegeneration, cancer, and the aging process. Research funding comes from an NIH R01, the March of Dimes and participation in other NIH grants.

Credentials

Faculty Appointments

Education

1984
BS | SUNY at Stony Brook
Biology

1989
PhD | University of Cincinnati
Developmental Biology

Awards

2005
Dean's Research Incentive Award University of Rochester Medical Center

2005
Ruth A. Lawrence Academic Faculty Service Award Department of Pediatrics

2004
Dean's Research Incentive Award University of Rochester

1993 - 1995
National Research Council NICHD, NIH

1986 - 1988
NIH Training Grant, University of Cincinnati

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Publications

Journal Articles

4/2017
Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA. "Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells." American journal of respiratory cell and molecular biology.. 2017 Apr 0; 56(4):453-464.

3/2017
O'Reilly MA. "Giving New Identities to Alveolar Epithelial Type I Cells." American journal of respiratory cell and molecular biology.. 2017 Mar 0; 56(3):277-278.

5/2016
Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA. "The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung." Stem cells.. 2016 May 0; 34(5):1396-406. Epub 2016 Mar 07.

Books & Chapters

2005
Chapter Title: Cell and Animal Models of Lung Injury
Book Title: Lung Injury: Mechanisms, Pathophysiology, and Therapy
Author List: Finkelstein JN, O'Reilly MA, Holm BA, Chess PC, Notter RH
Published By: Marcel Dekker2005 in New York, NY

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Videos

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Many 'Adult' Diseases Trace Back to Baby's Earliest Days