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Fred Hagen, Ph.D.


Showing all 44 journal articles & 2 books available

Journal Articles

De C, Liu D, Zheng B, Singh US, Chavre S, White C, Arnold RD, Hagen FK, Chu CK, Moffat JF. "?-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism." Antiviral research.. 2014 Oct 0; 110:10-9. Epub 2014 Jul 19.

Tian L, Wang C, Hagen FK, Gormley M, Addya S, Soccio R, Casimiro MC, Zhou J, Powell MJ, Xu P, Deng H, Sauve AA, Pestell RG. "Acetylation-defective mutant of Ppar? is associated with decreased lipid synthesis in breast cancer cells." Oncotarget. 2014 Sep 15; 5(17):7303-15.

Beckham CJ, Olsen J, Yin PN, Wu CH, Ting HJ, Hagen FK, Scosyrev E, Messing EM, Lee YF. "Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression." The Journal of urology.. 2014 Aug 0; 192(2):583-92. Epub 2014 Feb 14.

Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Hagen FK, Abranches J, Lemos JA. "Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence." Journal of bacteriology.. 2014 Aug 0; 196(15):2789-97. Epub 2014 May 16.

Nadtochiy SM, Madukwe J, Hagen F, Brookes PS. "Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection." British journal of pharmacology.. 2014 Apr 0; 171(8):2091-8.

Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT. "Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells." The Journal of biological chemistry.. 2013 Nov 22; 288(47):33542-58. Epub 2013 Oct 02.

Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD. "The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C." The Journal of biological chemistry.. 2012 Jul 13; 287(29):24698-712. Epub 2012 May 14.

Wangler NJ, Santos KL, Schadock I, Hagen FK, Escher E, Bader M, Speth RC, Karamyan VT. "Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site." The Journal of biological chemistry.. 2012 Jan 2; 287(1):114-22. Epub 2011 Oct 28.

Hagen FK. "Proteoglycan: site mapping and site-directed mutagenesis." Methods in molecular biology.. 2012 836:23-34.

Marimuthu S, Chivukula RS, Alfonso LF, Moridani M, Hagen FK, Bhat GJ. "Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets." International journal of oncology.. 2011 Nov 0; 39(5):1273-83. Epub 2011 Jul 04.

Griffiths AE, Wang W, Hagen FK, Fay PJ. "Use of affinity-directed liquid chromatography-mass spectrometry to map the epitopes of a factor VIII inhibitor antibody fraction." Journal of thrombosis and haemostasis : JTH.. 2011 Aug 0; 9(8):1534-40.

Nasim S, Pei S, Hagen FK, Jordan CT, Crooks PA. "Melampomagnolide B: a new antileukemic sesquiterpene." Bioorganic & medicinal chemistry.. 2011 Feb 15; 19(4):1515-9. Epub 2011 Jan 06.

Ambatipudi K, Hagen FK, Delahunty CM, Han X, Shafi R, Hryhorenko J, Gregoire S, Marquis R, Melvin JE, Koo H, Yates JR. "Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface." Journal of proteome research.. 2010 Dec 3; 9(12):6605-14. Epub 2010 Oct 22.

Ambatipudi K, Lu B, Hagen FK, Melvin JE, Yates JR. "Quantitative analysis of age specific variation in the abundance of human female parotid salivary proteins." Journal of proteome research.. 2009 Nov 0; 8(11):5093-102.

Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR. "Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)." Journal of proteome research.. 2009 Mar 0; 8(3):1304-14.

Yan W, Apweiler R, Balgley BM, Boontheung P, Bundy JL, Cargile BJ, Cole S, Fang X, Gonzalez-Begne M, Griffin TJ, Hagen F, Hu S, Wolinsky LE, Lee CS, Malamud D, Melvin JE, Menon R, Mueller M, Qiao R, Rhodus NL, Sevinsky JR, States D, Stephenson JL, Than S, Yates JR, Yu W, Xie H, Xie Y, Omenn GS, Loo JA, Wong DT. "Systematic comparison of the human saliva and plasma proteomes." Proteomics. Clinical applications. 2009 Jan 1; 3(1):116-134.

Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ. "The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions." Journal of proteome research.. 2008 May 0; 7(5):1994-2006. Epub 2008 Mar 25.

Tenno M, Ohtsubo K, Hagen FK, Ditto D, Zarbock A, Schaerli P, von Andrian UH, Ley K, Le D, Tabak LA, Marth JD. "Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity." Molecular and cellular biology.. 2007 Dec 0; 27(24):8783-96. Epub 2007 Oct 08.

Wang H, Julenius K, Hryhorenko J, Hagen FK. "Systematic Analysis of proteoglycan modification sites in Caenorhabditis elegans by scanning mutagenesis." The Journal of biological chemistry.. 2007 May 11; 282(19):14586-97. Epub 2007 Mar 16.

Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK. "The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation." Molecular biology of the cell.. 2005 Sep 0; 16(9):4202-13. Epub 2005 Jun 29.

Wojczyk BS, Stwora-Wojczyk MM, Hagen FK, Striepen B, Hang HC, Bertozzi CR, Roos DS, Spitalnik SL. "cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii." Molecular and biochemical parasitology.. 2003 Oct 0; 131(2):93-107.

Ten Hagen KG, Bedi GS, Tetaert D, Kingsley PD, Hagen FK, Balys MM, Beres TM, Degand P, Tabak LA. "Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9." The Journal of biological chemistry.. 2001 May 18; 276(20):17395-404. Epub 2001 Feb 06.

Hagen, F.K.; Layden, M.; Nehrke, K.; Gentile, K.; Berbach, K.; Tsao, C.C.; Forsythe, M. "Mucin-type O-Glycosylation in C. elegans is initiated by a family of glycosyltransferases." TIGG. 2001; 131: 463-479.

Ten Hagen KG, Tetaert D, Hagen FK, Richet C, Beres TM, Gagnon J, Balys MM, VanWuyckhuyse B, Bedi GS, Degand P, Tabak LA. "Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity." The Journal of biological chemistry.. 1999 Sep 24; 274(39):27867-74.

Hagen FK, Hazes B, Raffo R, deSa D, Tabak LA. "Structure-function analysis of the UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor fold." The Journal of biological chemistry.. 1999 Mar 5; 274(10):6797-803.

Ten Hagen KG, Hagen FK, Balys MM, Beres TM, Van Wuyckhuyse B, Tabak LA. "Cloning and expression of a novel, tissue specifically expressed member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family." The Journal of biological chemistry.. 1998 Oct 16; 273(42):27749-54.

Hagen FK, Nehrke K. "cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans." The Journal of biological chemistry.. 1998 Apr 3; 273(14):8268-77.

Nehrke K, Hagen FK, Tabak LA. "Isoform-specific O-glycosylation by murine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, in vivo." Glycobiology.. 1998 Apr 0; 8(4):367-71.

Nehrke K, Ten Hagen KG, Hagen FK, Tabak LA. "Charge distribution of flanking amino acids inhibits O-glycosylation of several single-site acceptors in vivo." Glycobiology.. 1997 Dec 0; 7(8):1053-60.

Wragg S, Hagen FK, Tabak LA. "Identification of essential histidine residues in UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T1." The Biochemical journal.. 1997 Nov 15; 328 ( Pt 1):193-7.

Hagen FK, Ten Hagen KG, Beres TM, Balys MM, VanWuyckhuyse BC, Tabak LA. "cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase." The Journal of biological chemistry.. 1997 May 23; 272(21):13843-8.

Zara J, Hagen FK, Ten Hagen KG, Van Wuyckhuyse BC, Tabak LA. "Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3." Biochemical and biophysical research communications.. 1996 Nov 1; 228(1):38-44.

Albone EF, Hagen FK, Szpirer C, Tabak LA. "Molecular cloning and characterization of the gene encoding rat submandibular gland apomucin, Mucsmg." Glycoconjugate journal.. 1996 Oct 0; 13(5):709-16.

Brockhausen I, Toki D, Brockhausen J, Peters S, Bielfeldt T, Kleen A, Paulsen H, Meldal M, Hagen F, Tabak LA. "Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates." Glycoconjugate journal.. 1996 Oct 0; 13(5):849-56.

Nehrke K, Hagen FK, Tabak LA. "Charge distribution of flanking amino acids influences O-glycan acquisition in vivo." The Journal of biological chemistry.. 1996 Mar 22; 271(12):7061-5.

Brockhausen, I.; Toki, D.; Brockhausen, J.; Peters, S.; Bielfeldt, T.; Kleen, A.; Paulsen, H.; Medal, M.; Hagen, F.;Tabak, L.A. "Specificity of O-glycosylation by bovine colostrum UDP-GalNac:polypeptide N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates." Glycoconj. J. 1996; 5: 849-856.

Hennet T, Hagen FK, Tabak LA, Marth JD. "T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination." Proceedings of the National Academy of Sciences of the United States of America.. 1995 Dec 19; 92(26):12070-4.

Hagen FK, Gregoire CA, Tabak LA. "Cloning and sequence homology of a rat UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase." Glycoconjugate journal.. 1995 Dec 0; 12(6):901-9.

Wragg S, Hagen FK, Tabak LA. "Kinetic analysis of a recombinant UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase." The Journal of biological chemistry.. 1995 Jul 14; 270(28):16947-54.

Albone EF, Hagen FK, VanWuyckhuyse BC, Tabak LA. "Molecular cloning of a rat submandibular gland apomucin." The Journal of biological chemistry.. 1994 Jun 17; 269(24):16845-52.

Hagen FK, Van Wuyckhuyse B, Tabak LA. "Purification, cloning, and expression of a bovine UDP-GalNAc: polypeptide N-acetyl-galactosaminyltransferase." The Journal of biological chemistry.. 1993 Sep 5; 268(25):18960-5.

O'Connell BC, Hagen FK, Tabak LA. "The influence of flanking sequence on the O-glycosylation of threonine in vitro." The Journal of biological chemistry.. 1992 Dec 15; 267(35):25010-8.

Aiken JM, Miller FD, Hagen F, McKenzie DI, Krawetz SA, van de Sande JH, Rattner JB, Dixon GH. "Tandem repeats of a specific alternating purine-pyrimidine DNA sequence adjacent to protamine genes in the rainbow trout that can exist in the Z form." Biochemistry.. 1985 Oct 22; 24(22):6268-76.

Hagen FK, Zarling DA, Jovin TM. "Electron microscopy of SV40 DNA cross-linked by anti-Z DNA IgG." The EMBO journal.. 1985 Mar 0; 4(3):837-44.

Books & Chapters

Chapter Title: UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases.
Book Title: Handbook of Glycosyltransferases and Their Related Genes
Author List: Hagen, F.K.; Ten Hagen, K.G.; Tabak ,L.A.
Edited By: N. Taniguchi and M. Fukuda
Published By: Springer-Verlag2003 in Tokyo

Chapter Title: Experimental approaches to studying O-glycosylation in vivo.
Book Title: Techniques in Glycobiology
Author List: Nehrke, K.N.; Hagen, F.K.; Tabak, L.A .
Edited By: R.R. Townsend
Published By: Marcel Dekker, Inc.1996 in New York