Alice P. Pentland, M.D.

Alice P. Pentland, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 697
Rochester, NY 14642

Fax: (585) 273-1346
Administrative: (585) 275-1998

Journal Articles

Showing all 71 journal articles available.

2016 Nov
Barlow ML, Cummings RJ, Pentland AP, Love TM, Haidaris CG, Ryan JL, Lord EM, Gerber SA. "Total-Body Irradiation Exacerbates Dissemination of Cutaneous Candida Albicans Infection." Radiation research. 2016 Nov; 186(5):436-446. Epub 2016 Oct 06.
2016 Apr
Chen L, Oleksyn D, Pulvino M, Sanz I, Ryan D, Ryan C, Lin CS, Poligone B, Pentland AP, Ritchlin C, Zhao J. "A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells." Immunology letters. 2016 Apr; 172:67-78. Epub 2016 Feb 26.
2015 Mar
Poligone B, Gilmore ES, Alexander C, Oleksyn D, Gillespie K, Zhao J, Ibrahim S, Pentland AP, Brown M, Chen L. "PKK suppresses tumor growth and is decreased in squamous cell carcinoma of the skin." The Journal of investigative dermatology. 2015 Mar; 135(3):869-76. Epub 2014 Oct 06.
2015 Jan
Gerber SA, Cummings RJ, Judge JL, Barlow ML, Nanduri J, Johnson DE, Palis J, Pentland AP, Lord EM, Ryan JL. "Interleukin-12 preserves the cutaneous physical and immunological barrier after radiation exposure." Radiation research. 2015 Jan; 183(1):72-81. Epub 2015 Jan 07.
2014 Aug
Mantel A, Carpenter-Mendini A, VanBuskirk J, Pentland AP. "Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism." Experimental dermatology. 2014 Aug; 23(8):573-8. Epub 2014 Jul 16.
2013 Jul
Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. "Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients." Radiation research. 2013 Jul; 180(1):34-43. Epub 2013 Jun 07.
Poligone B, Hayden MS, Chen L, Pentland AP, Jimi E, Ghosh S. "A role for NF-?B activity in skin hyperplasia and the development of keratoacanthomata in mice." PloS one. 2013 8(8):e71887. Epub 2013 Aug 19.
2012 Nov 1
Cummings RJ, Gerber SA, Judge JL, Ryan JL, Pentland AP, Lord EM. "Exposure to ionizing radiation induces the migration of cutaneous dendritic cells by a CCR7-dependent mechanism." The Journal of immunology : official journal of the American Association of Immunologists. 2012 Nov 1; 189(9):4247-57. Epub 2012 Sep 21.
2012 Apr
Mantel A, Carpenter-Mendini AB, Vanbuskirk JB, De Benedetto A, Beck LA, Pentland AP. "Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis." The Journal of investigative dermatology. 2012 Apr; 132(4):1103-10. Epub 2011 Dec 15.
2012 Mar
Pentland AP, Hall RP, Yancey KB. "Happy birthday, Society for Investigative Dermatology." The Journal of investigative dermatology. 2012 Mar; 132(3 Pt 1):495.
2012 Mar
Pentland AP, Connolly NL, Fahner-Vihtelic JE. "Patents and growth." The Journal of investigative dermatology. 2012 Mar; 132(3 Pt 2):1037-41.
2010 Dec 15
Elmets CA, Viner JL, Pentland AP, Cantrell W, Lin HY, Bailey H, Kang S, Linden KG, Heffernan M, Duvic M, Richmond E, Elewski BE, Umar A, Bell W, Gordon GB. "Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial." Journal of the National Cancer Institute. 2010 Dec 15; 102(24):1835-44. Epub 2010 Nov 29.
2009 May
Gonzales UP, Scott GA, Briones AJ, Pentland AP. "Remote hemorrhagic bullae occurring in a patient treated with subcutaneous heparin." Archives of dermatology. 2009 May; 145(5):604-5.
2008 Sep
Mortensen LJ, Oberdörster G, Pentland AP, Delouise LA. "In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR." Nano letters. 2008 Sep; 8(9):2779-87. Epub 2008 Aug 08.
2008 Mar
Erdle BJ, Brouxhon S, Kaplan M, Vanbuskirk J, Pentland AP. "Effects of continuous-wave (670-nm) red light on wound healing." Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 2008 Mar; 34(3):320-5. Epub 2007 Dec 20.
Horwitz CM, Mueller M, Wiley D, Tentler A, Bocko M, Chen L, Leibovici A, Quinn J, Shar A, Pentland AP. "Is home health technology adequate for proactive self-care?" Methods of information in medicine. 2008 47(1):58-62.
2007 Aug 15
Brouxhon S, Kyrkanides S, O'Banion MK, Johnson R, Pearce DA, Centola GM, Miller JN, McGrath KH, Erdle B, Scott G, Schneider S, VanBuskirk J, Pentland AP. "Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism." Cancer research. 2007 Aug 15; 67(16):7654-64.
2007 Jul 2
Ryan JL, Bole C, Hickok JT, Figueroa-Moseley C, Colman L, Khanna RC, Pentland AP, Morrow GR. "Post-treatment skin reactions reported by cancer patients differ by race, not by treatment or expectations." British journal of cancer. 2007 Jul 2; 97(1):14-21. Epub 2007 Jun 12.
2007 Feb
Brouxhon S, Konger RL, VanBuskirk J, Sheu TJ, Ryan J, Erdle B, Almudevar A, Breyer RM, Scott G, Pentland AP. "Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness." The Journal of investigative dermatology. 2007 Feb; 127(2):439-46. Epub 2006 Sep 14.
2006 Apr
Scott GA, Jacobs SE, Pentland AP. "sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism." The Journal of investigative dermatology. 2006 Apr; 126(4):855-61.
2005 Dec
Konger RL, Brouxhon S, Partillo S, VanBuskirk J, Pentland AP. "The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes." Experimental dermatology. 2005 Dec; 14(12):914-22.
2005 Dec
Rodriguez-Burford C, Tu JH, Mercurio M, Carey D, Han R, Gordon G, Niwas S, Bell W, Elmets CA, Grizzle W, Pentland AP. "Selective cyclooxygenase-2 inhibition produces heterogeneous erythema response to ultraviolet irradiation." The Journal of investigative dermatology. 2005 Dec; 125(6):1317-20.
2005 May
Konger RL, Billings SD, Thompson AB, Morimiya A, Ladenson JH, Landt Y, Pentland AP, Badve S. "Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermis." The Journal of investigative dermatology. 2005 May; 124(5):965-70.
2004 Aug 15
Pentland AP, Scott G, VanBuskirk J, Tanck C, LaRossa G, Brouxhon S. "Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors." Cancer research. 2004 Aug 15; 64(16):5587-91.
2003 Oct
Tripp CS, Blomme EA, Chinn KS, Hardy MM, LaCelle P, Pentland AP. "Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection." The Journal of investigative dermatology. 2003 Oct; 121(4):853-61.
2003 Jan
Rys-Sikora KE, Pentland AP, Konger RL. "Pertussis toxin-sensitive secretory phospholipase A2 expression and motility in activated primary human keratinocytes." The Journal of investigative dermatology. 2003 Jan; 120(1):86-95.
2002 Dec
Konger RL, Scott GA, Landt Y, Ladenson JH, Pentland AP. "Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression." The American journal of pathology. 2002 Dec; 161(6):2065-78.
2002 Jun
Pentland AP. "Cyclooxygenase inhibitors for skin cancer prevention: are they beneficial enough?" Archives of dermatology. 2002 Jun; 138(6):823-4.
Pentland AP, Pentland AP. "Inventing the future--tools for self health." Studies in health technology and informatics. 2002 80:19-25.
2000 Apr
Rys-Sikora KE, Konger RL, Schoggins JW, Malaviya R, Pentland AP. "Coordinate expression of secretory phospholipase A(2) and cyclooxygenase-2 in activated human keratinocytes." American journal of physiology. Cell physiology. 2000 Apr; 278(4):C822-33.
1999 Oct
Pentland AP, Schoggins JW, Scott GA, Khan KN, Han R. "Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition." Carcinogenesis. 1999 Oct; 20(10):1939-44.
Buckman SY, Koki AT, Edwards DA, Pentland AP. "Immunohistochemical analysis of cyclooxygenase expression in human skin." Methods in molecular biology. 1999 120:35-43.
1998 May 22
Guan Z, Buckman SY, Pentland AP, Templeton DJ, Morrison AR. "Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway." The Journal of biological chemistry. 1998 May 22; 273(21):12901-8.
1998 May
Buckman SY, Gresham A, Hale P, Hruza G, Anast J, Masferrer J, Pentland AP. "COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer." Carcinogenesis. 1998 May; 19(5):723-9.
1998 Feb 4
Konger RL, Malaviya R, Pentland AP. "Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes." Biochimica et biophysica acta. 1998 Feb 4; 1401(2):221-34.
1997 May
Sudbeck BD, Pilcher BK, Pentland AP, Parks WC. "Modulation of intracellular calcium levels inhibits secretion of collagenase 1 by migrating keratinocytes." Molecular biology of the cell. 1997 May; 8(5):811-24.
1996 Apr
Malaviya R, Morrison AR, Pentland AP. "Histamine in human epidermal cells is induced by ultraviolet light injury." The Journal of investigative dermatology. 1996 Apr; 106(4):785-9.
1996 Apr
Gresham A, Masferrer J, Chen X, Leal-Khouri S, Pentland AP. "Increased synthesis of high-molecular-weight cPLA2 mediates early UV-induced PGE2 in human skin." The American journal of physiology. 1996 Apr; 270(4 Pt 1):C1037-50.
1996 Apr
Pentland AP. "Signal transduction mechanisms in photocarcinogenesis." Photochemistry and photobiology. 1996 Apr; 63(4):379-80.
1996 Jan 5
Chen X, Gresham A, Morrison A, Pentland AP. "Oxidative stress mediates synthesis of cytosolic phospholipase A2 after UVB injury." Biochimica et biophysica acta. 1996 Jan 5; 1299(1):23-33.
1996 Jan
Andley UP, Becker B, Hebert JS, Reddan JR, Morrison AR, Pentland AP. "Enhanced prostaglandin synthesis after ultraviolet-B exposure modulates DNA synthesis of lens epithelial cells and lowers intraocular pressure in vivo." Investigative ophthalmology & visual science. 1996 Jan; 37(1):142-53.
1995 Jan
Pentland AP, Shapiro SD, Welgus HG. "Agonist-induced expression of tissue inhibitor of metalloproteinases and metalloproteinases by human macrophages is regulated by endogenous prostaglandin E2 synthesis." The Journal of investigative dermatology. 1995 Jan; 104(1):52-7.
1994 Nov 25
Sudbeck BD, Parks WC, Welgus HG, Pentland AP. "Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities." The Journal of biological chemistry. 1994 Nov 25; 269(47):30022-9.
1994 Sep
Okada N, Pentland AP, Falk P, Caparon MG. "M protein and protein F act as important determinants of cell-specific tropism of Streptococcus pyogenes in skin tissue." The Journal of clinical investigation. 1994 Sep; 94(3):965-77.
1994 Jul
Saarialho-Kere UK, Pentland AP, Birkedal-Hansen H, Parks WC, Welgus HG. "Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds." The Journal of clinical investigation. 1994 Jul; 94(1):79-88.
1994 Feb 4
Miller CC, Hale P, Pentland AP. "Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation." The Journal of biological chemistry. 1994 Feb 4; 269(5):3529-33.
1994 Feb
Andley UP, Hebert JS, Morrison AR, Reddan JR, Pentland AP. "Modulation of lens epithelial cell proliferation by enhanced prostaglandin synthesis after UVB exposure." Investigative ophthalmology & visual science. 1994 Feb; 35(2):374-81.
1994 Jan
Hussain H, Shornick LP, Shannon VR, Wilson JD, Funk CD, Pentland AP, Holtzman MJ. "Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis." The American journal of physiology. 1994 Jan; 266(1 Pt 1):C243-53.
Pentland AP. "Active oxygen mechanisms of UV inflammation." Advances in experimental medicine and biology. 1994 366:87-97.
1993 Dec
Saarialho-Kere UK, Kovacs SO, Pentland AP, Olerud JE, Welgus HG, Parks WC. "Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing." The Journal of clinical investigation. 1993 Dec; 92(6):2858-66.
1993 Apr 15
Shapiro SD, Kobayashi DK, Pentland AP, Welgus HG. "Induction of macrophage metalloproteinases by extracellular matrix. Evidence for enzyme- and substrate-specific responses involving prostaglandin-dependent mechanisms." The Journal of biological chemistry. 1993 Apr 15; 268(11):8170-5.
1993 Feb
Kang-Rotondo CH, Miller CC, Morrison AR, Pentland AP. "Enhanced keratinocyte prostaglandin synthesis after UV injury is due to increased phospholipase activity." The American journal of physiology. 1993 Feb; 264(2 Pt 1):C396-401.
1993 Jan
Hruza LL, Pentland AP. "Mechanisms of UV-induced inflammation." The Journal of investigative dermatology. 1993 Jan; 100(1):35S-41S.
1992 Aug 5
Pentland AP, Morrison AR, Jacobs SC, Hruza LL, Hebert JS, Packer L. "Tocopherol analogs suppress arachidonic acid metabolism via phospholipase inhibition." The Journal of biological chemistry. 1992 Aug 5; 267(22):15578-84.
1991 Oct 18
Schiro JA, Chan BM, Roswit WT, Kassner PD, Pentland AP, Hemler ME, Eisen AZ, Kupper TS. "Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells." Cell. 1991 Oct 18; 67(2):403-10.
1991 Sep
Pentland AP, Jacobs SC. "Bradykinin-induced prostaglandin synthesis is enhanced in keratinocytes and fibroblasts by UV injury." The American journal of physiology. 1991 Sep; 261(3 Pt 2):R543-7.
1991 Jun
Udey MC, Peck RD, Pentland AP, Schreiner GF, Lefkowith JB. "Antigen-presenting cells in essential fatty acid-deficient murine epidermis: keratinocytes bearing class II (Ia) antigens may potentiate the accessory cell function of Langerhans cells." The Journal of investigative dermatology. 1991 Jun; 96(6):950-8.
1990 Aug
Pentland AP, Mahoney M, Jacobs SC, Holtzman MJ. "Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema." The Journal of clinical investigation. 1990 Aug; 86(2):566-74.
1990 Jan
Pentland AP, Mahoney MG. "Keratinocyte prostaglandin synthesis is enhanced by IL-1." The Journal of investigative dermatology. 1990 Jan; 94(1):43-6.
1989 May
Pentland AP. "Collagen lattice effects on fibroblast arachidonic acid metabolism." Journal of cellular physiology. 1989 May; 139(2):392-7.
1989 Apr
HE CS, Wilhelm SM, Pentland AP, Marmer BL, Grant GA, Eisen AZ, Goldberg GI. "Tissue cooperation in a proteolytic cascade activating human interstitial collagenase." Proceedings of the National Academy of Sciences of the United States of America. 1989 Apr; 86(8):2632-6.
Bauer EA, Pentland AP, Kronberger A, Wilhelm SM, Goldberg GI, Welgus HG, Eisen AZ. "Keratinocyte- and tumor-derived inducers of collagenase." Annals of the New York Academy of Sciences. 1988 548:174-9.
1987 Jun
Eisen AZ, Pentland AP, Bauer EA, Goldberg GI. "Behavior of epidermolysis bullosa fibroblasts in a hydrated collagen lattice." The Journal of investigative dermatology. 1987 Jun; 88(6):741-6.
1987 May 13
Pentland AP, George J, Moran C, Needleman P. "Cellular confluence determines injury-induced prostaglandin E2 synthesis by human keratinocyte cultures." Biochimica et biophysica acta. 1987 May 13; 919(1):71-8.
1987 Apr
Pentland AP. "A new sense for depth of field." IEEE transactions on pattern analysis and machine intelligence. 1987 Apr; 9(4):523-31.
1986 Feb
Pentland AP, Marcelo CL, Jordan MA, Voorhees JJ. "Effects of gas tension on epidermal keratinocyte DNA synthesis and prostaglandin production." The Journal of investigative dermatology. 1986 Feb; 86(2):177-80.
1986 Jan
Pentland AP, Needleman P. "Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis." The Journal of clinical investigation. 1986 Jan; 77(1):246-51.
1985 Jan
Pentland AP, Anderson TF. "Plantar fibromatosis responds to intralesional steroids." Journal of the American Academy of Dermatology. 1985 Jan; 12(1 Pt 2):212-4.
1984 Oct
Fairley JA, Pentland AP, Voorhees JJ. "Urticaria pigmentosa responsive to nifedipine." Journal of the American Academy of Dermatology. 1984 Oct; 11(4 Pt 2):740-3.
1984 Feb
Pentland AP. "Local shading analysis." IEEE transactions on pattern analysis and machine intelligence. 1984 Feb; 6(2):170-87.
1983 Apr 15
Pentland AP, Marcelo CL. "Modulation of proliferation in epidermal keratinocyte cultures by lowered oxygen tension." Experimental cell research. 1983 Apr 15; 145(1):31-43.


Pentland AP. "Photobiology of the Skin". Biophontics. Pavesi and Fauchet. : Springer-Verlag, Berlin Heidelberg, 2008. 301-314
Pentland, AP. "Eicosanoids". Dermatology in General Medicine. Freedberg, Eisen, Wolff, Austen, Goldsmith, Katz. : McGraw-Hill, 2003. 343
Pentland, Alice P and Pentland, Alex P. "Inventing the Future - Tools for Self Health". Future of Health Technology. R. Bushko. Amsterdam: IOS Press, 2002. 19-25
Pentland, AP. "Arachidonic Acid Metabolism". Fitzpatrick's Dermatology in General Medicine. : McGraw-Hill, 1998.
Pentland, AP. "Dermatology in General Medicine: Fitzpatrick's Dermatology in General Medicine,". Metabolism of Arachidonic Acid in Skin. : McGraw-Hill, 1993.