My primary research interest is energy generation in the heart, both physiologically and pathologically. Energy in form of ATP is made by mitochondria and necessary to keep the heart working and even apoptotic cell death requires energy. My special research interest is the mitochondrial permeability transition pore. Although a variety of mitochondrial proteins have been hypothesized to constitute the pore, the structural components are still not identified. It is well established that opening of the permeability transition pore will lead to apoptotic cell death. However, the physiological role of this pore is much less understood. My research will focus on the identification of the components of the permeability transition pore and how this pore is regulated during cardiac development. Experimental models of my research will include isolate mitochondria from the heart, primary cultured cardiac myocytes and in vivo models like transgenic mice.
PhD | Germany-University of Konstanz
Diploma | Germany - University of Osnabrück
Young Investigator Award
Sponsor: Bioenergetics of the Biophysical Society
Sponsor: European Bioenergetics Conference
Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA. "Physiological roles of the mitochondrial permeability transition pore." Journal of bioenergetics and biomembranes.. 2017 Feb 0; 49(1):13-25. Epub 2016 Feb 11.
Beutner G, Kambiz AN, Jonas EA, Porter GA. "The Mitochondrial Permeability Transition Pore and ATP Synthase." Handbook of experimental pharmacology.. 2017 240:21-46.
Yang YP, Lotta L, Beutner G, Li X, Schor NF. "Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II." Oxidative medicine and cellular longevity.. 2016 2016:8752821. Epub 2015 Nov 10.
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