Gisela Beutner, Ph.D.

Gisela Beutner, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 631
Rochester, NY 14642

Research Bio

My primary research interest is energy generation in the heart, both physiologically and pathologically. Energy in form of ATP is made by mitochondria and necessary to keep the heart working and even apoptotic cell death requires energy. My special research interest is the mitochondrial permeability transition pore. Although a variety of mitochondrial proteins have been hypothesized to constitute the pore, the structural components are still not identified. It is well established that opening of the permeability transition pore will lead to apoptotic cell death. However, the physiological role of this pore is much less understood.

My research will focus on the identification of the components of the permeability transition pore and how this pore is regulated during cardiac development. Experimental models of my research will include isolate mitochondria from the heart, primary cultured cardiac myocytes and in vivo models like transgenic mice.

Awards & Honors (Local)

Young Investigator Award | Bioenergetics of the Biophysical Society 2001
Travel Award | European Bioenergetics Conference | Louvain-La-Neuv/Belgium 1996

Recent Journal Articles

Showing the 5 most recent journal articles. 22 available »

2016 Sep 3
Beutner G, Kambiz AN, Jonas EA, Porter GA. "The Mitochondrial Permeability Transition Pore and ATP Synthase." Handbook of experimental pharmacology. 2016 Sep 3; Epub 2016 Sep 03.
2016 Feb 11
Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA. "Physiological roles of the mitochondrial permeability transition pore." Journal of bioenergetics and biomembranes. 2016 Feb 11; Epub 2016 Feb 11.
2016
Yang YP, Lotta L, Beutner G, Li X, Schor NF. "Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II." Oxidative medicine and cellular longevity. 2016 2016:8752821. Epub 2015 Nov 10.
2015 Sep
Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Alavian KN. "Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase." Pharmacological research. 2015 Sep; 99:382-92. Epub 2015 May 05.
2014 Jul 22
Alavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA, Jonas EA. "An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore." Proceedings of the National Academy of Sciences of the United States of America. 2014 Jul 22; 111(29):10580-5. Epub 2014 Jun 16.

Current Appointments

Research Assistant Professor (Part-Time) - Department of Pediatrics, Cardiology (SMD) - Primary

Education

PhD | Biology | Germany-University of Konstanz1997
Diploma | Biology | Germany - University of Osnabrück1993

Post-Doctoral Training & Residency

Postdoctoral fellow at University of Rochester Department of Pharmacology and Physiology 2002