Kuang-Hsiang Chuang, Ph.D.

Kuang-Hsiang Chuang, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 647
Rochester, NY 14642

Office: (585) 276-6122

Research Bio

My recent research mainly uses epigenetic approaches to address clinical needs in the areas of early disease diagnosis, prognosis and therapy. The major focuses of my recent research projects are on two topics: 1) Regulation of DNA damage response via histone methylation/demethylation modulation to change cellular radiosensitivity. 2) Regulation of multiple tumor suppressor genes by specific microRNAs through controlling epigenetic machinery during tumor progression. I work closely with translational research teams comprised of surgeons, pathologists, and oncologists in order to develop new molecular approaches and discover new biomarker for early disease detection, staging, and treatment.

The goal achievement of my research will be of great importance for both basic research and translational medicine in future, as these results will provide insights into epigenetic regulation in cellular radiosensitivity, and allow major advances to be made in clinical applications of radiation therapy in cancer.

Recent Journal Articles

Showing the 5 most recent journal articles. 18 available »

2015 Jun
Barry CT, Hazard C, Hah Z, Cheng G, Partin A, Mooney RA, Chuang KH, Cao W, Rubens DJ, Parker KJ. "Shear wave dispersion in lean versus steatotic rat livers." Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2015 Jun; 34(6):1123-9.
Chuang KH, Whitney-Miller CL, Chu CY, Zhou Z, Dokus MK, Schmit S, Barry CT. "MicroRNA-494 Is a Master Epigenetic Regulator of Multiple Invasion-Suppressor MicroRNAs by Targeting Ten Eleven Translocation 1 in Invasive Human Hepatocellular Carcinoma Tumors". Hepatology. 2015; 62(2): 466-480.
2014 Apr
Barry CT, Hah Z, Partin A, Mooney RA, Chuang KH, Augustine A, Almudevar A, Cao W, Rubens DJ, Parker KJ. "Mouse liver dispersion for the diagnosis of early-stage Fatty liver disease: a 70-sample study." Ultrasound in medicine & biology. 2014 Apr; 40(4):704-13. Epub 2014 Jan 10.
2013 Jan
Lai KP, Lai JJ, Chang P, Altuwaijri S, Hsu JW, Chuang KH, Shyr CR, Yeh S, Chang C. "Targeting thymic epithelia AR enhances T-cell reconstitution and bone marrow transplant grafting efficacy." Molecular endocrinology. 2013 Jan; 27(1):25-37. Epub 0/18/2012.
2012 Nov
Lai JJ, Lai KP, Zeng W, Chuang KH, Altuwaijri S, Chang C. "Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice." The American journal of pathology. 2012 Nov; 181(5):1504-12. Epub 2012 Sep 04.

Current Appointments

Research Assistant Professor - Department of Radiation Oncology (SMD) - Primary


PhD | Pathology | University of Rochester School of Medicine & Dentistry2004
MS | Pathology | University of Rochester School of Medicine & Dentistry2001
MS | Biochemistry and Molecular Biology | Taiwan-National Yang-Ming University, Taipei1993
BS | Medical Technology | Taiwan-National Yang-Ming University, Taipei1991

Post-Doctoral Training & Residency

Postdoctorate in Pathology, University of Rochester, Rochester, NY 2006