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Kuang-Hsiang Chuang, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-6122

Biography

Research

My recent research mainly uses epigenetic approaches to address clinical needs in the areas of early disease diagnosis, prognosis, and therapy. The major focuses of my recent research projects are on two topics: 1) Regulation of DNA damage response via histone or non-histone methylation/demethylation modulation to change cellular radiosensitivity. 2) Regulation of multiple tumor suppressor genes by specific microRNAs through controlling epigenetic machinery during tumor progression. I work closely with translational research teams comprised of surgeons, pathologists, and oncologists in order to develop new molecular approaches and discover new biomarker for early disease detection, staging, and treatment. The goal achievement of my research will be of great importance for both basic research and translational medicine in future, as these results will provide insights into epigenetic regulation in cellular radiosensitivity, and allow major advances to be made in clinical applications of radiation therapy in cancer.

Credentials

Faculty Appointments

Education

1991
BS | Taiwan-National Yang-Ming University, Taipei
Medical Technology

1993
MS | Taiwan-National Yang-Ming University, Taipei
Biochemistry and Molecular Biology

2004
PhD | University of Rochester School of Medicine & Dentistry
Pathology

2001
MS | University of Rochester School of Medicine & Dentistry
Pathology

Publications

Journal Articles

6/2015
Barry CT, Hazard C, Hah Z, Cheng G, Partin A, Mooney RA, Chuang KH, Cao W, Rubens DJ, Parker KJ. "Shear wave dispersion in lean versus steatotic rat livers." Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.. 2015 Jun 0; 34(6):1123-9.

2015
Chuang KH, Whitney-Miller CL, Chu CY, Zhou Z, Dokus MK, Schmit S, Barry CT. "MicroRNA-494 Is a Master Epigenetic Regulator of Multiple Invasion-Suppressor MicroRNAs by Targeting Ten Eleven Translocation 1 in Invasive Human Hepatocellular Carcinoma Tumors". Hepatology. 2015; 62(2): 466-480.

4/2014
Barry CT, Hah Z, Partin A, Mooney RA, Chuang KH, Augustine A, Almudevar A, Cao W, Rubens DJ, Parker KJ. "Mouse liver dispersion for the diagnosis of early-stage Fatty liver disease: a 70-sample study." Ultrasound in medicine & biology.. 2014 Apr 0; 40(4):704-13. Epub 2014 Jan 10.

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