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Norma B. Lerner, M.D., M.P.H.

Contact Information

Phone Numbers

Office: (585) 275-2981

Fax: (585) 273-1039

Biography

Hemoglobinopathies
Hemostasis

Research

Dr. Lerner's research interests are:

1) Cerebrovascular damage and neurocognitive complications in children with sickle cell disease
2) Anti-platelet effects of aspirin in children
3) Newborn genetics screening for the hemoglobinopathies
4) Soluble CD40 Ligand and its role of pediatric coagulopathies

Neurologic complications secondary to cerebrovascular damage are prevalent in children with sickle cell disease. While chronic transfusion therapy has been shown to effectively prevent some of these complications, side effects and cost diminish its perceived value. Aspirin is a widely used anti-platelet agent that has proven efficacy in prevention studies involving adults with vascular disease.

Dr. Lerner has begun a three-year pilot trial to test the feasibility and safety of prophylactic aspirin administration in children with sickle cell disease between the ages of 3 and 10 years. This is a phase I/II randomized placebo-controlled double blind study. Pilot data regarding the effect of aspirin therapy on magnetic resonance imaging (MRI), magnetic resonance angiography (MRA) studies, neuropsychological testing, and transcranial Doppler (TCD) ultrasound will also be gathered. They anticipate a larger phase III trial to test the efficacy of prophylactic aspirin therapy for the prevention of neurologic complications in children with homozygous sickle cell disease in the future.

Credentials

Specialties

  • Pediatrics - American Board of Pediatrics
  • Pediatric Hematology-Oncology - American Board of Pediatrics

Education

1971
BA | Jackson College of Tufts University

1975
MD | Brown University
Medicine

2006
MPH | University of Rochester School of Medicine and Dentistry
Clinical Investigator

Post-doctoral Training & Residency

07/01/1975 - 06/30/1976
Internship in Pediatrics at Boston City Hospital

07/01/1976 - 06/30/1977
Residency in Pediatrics at Boston City Hospital

07/01/1977 - 06/30/1978
Residency in Pediatrics at Massachusetts General Hospital

07/01/1981 - 06/30/1983
Fellowship in Pediatrics: Pediatric Hematology/Oncology at Children's Hospital of Philadelphia

07/01/1983 - 06/30/1985
Fellowship in Pediatrics: Pediatric Hematology/Oncology at Memorial Sloan-Kettering Cancer Center

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Awards

2005 - 2006
Best Doctors in America

2004
Ruth A. Lawrence Faculty Service Award

2003
Ruth A. Lawrence Faculty Service Award

1996
SCRC Research Development Award

1985
Cooley's Anemia Foundation Grant Award

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Publications

Journal Articles

6/2006
Kirkham FJ, Lerner NB, Noetzel M, DeBaun MR, Datta AK, Rees DC, Adams RJ. "Trials in sickle cell disease." Pediatric neurology.. 2006 Jun 0; 34(6):450-8.

3/2006
Schwartz GJ, Lerner NB. "The kallikrein-kinin system in sickle cell nephropathy: does it play a role?" Journal of pediatric hematology/oncology.. 2006 Mar 0; 28(3):111-4.

2/3/2005
Agarwal A, Das K, Lerner N, Sathe S, Cicek M, Casey G, Sizemore N. "The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin." Oncogene.. 2005 Feb 3; 24(6):1021-31.

Books & Chapters

2006
Chapter Title: Perinatal Hematologic Disorders
Book Title: The Merck Manual
Author List: Cholette JM, Lerner NB
Edited By: Beers
Published By: Merck Research Laboratories2006 in New York, NY

2006
Chapter Title: Use of Blood Products
Book Title: Pediatric Critical Care Study Guide: Text and Review
Author List: Cholette JM, Lerner NB
Published By: Springer-Verlag2006 in New York, NY

2002
Chapter Title: Sickle Cell Disease
Book Title: The Pediatric Clinical Advisor
Author List: Lerner NB
Edited By: Garfunkel, Christy and Kaczorowski
Published By: Mosby, Inc.2002 in St. Louis, MO

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