Melanie A. Wellington, M.D., Ph.D.

Melanie A. Wellington, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 690
Rochester, NY 14642

Office: (585) 275-5944
Fax: (585) 273-1104
Lab: (585) 273-5459
Administrative: (585) 275-5944

Journal Articles

Showing all 22 journal articles available.

2016 Dec
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. "The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis." Antimicrobial agents and chemotherapy. 2016 Dec; 60(12):7115-7127. Epub 2016 Nov 21.
2014 Jun
Krysan DJ, Sutterwala FS, Wellington M. "Catching fire: Candida albicans, macrophages, and pyroptosis." PLoS pathogens. 2014 Jun; 10(6):e1004139. Epub 2014 Jun 26.
2014 Mar
Harrison BD, Hashemi J, Bibi M, Pulver R, Bavli D, Nahmias Y, Wellington M, Sapiro G, Berman J. "A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole." PLoS biology. 2014 Mar; 12(3):e1001815. Epub 2014 Mar 18.
2014 Feb 11
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, Didone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. "Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo." mBio. 2014 Feb 11; 5(1):e00765-13. Epub 2014 Feb 11.
2014 Feb
Wellington M, Koselny K, Sutterwala FS, Krysan DJ. "Candida albicans triggers NLRP3-mediated pyroptosis in macrophages." Eukaryotic cell. 2014 Feb; 13(2):329-40. Epub 2013 Dec 27.
2013 Feb
Butts A, Didone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. "A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis." Eukaryotic cell. 2013 Feb; 12(2):278-87. Epub 2012 Dec 14.
2012 Dec 26
Wellington M, Koselny K, Krysan DJ. "Candida albicans morphogenesis is not required for macrophage interleukin 1? production." mBio. 2012 Dec 26; 4(1):e00433-12. Epub 2012 Dec 26.
2012 Jul
Kajfasz JK, Mendoza JE, Gaca AO, Miller JH, Koselny KA, Giambiagi-Demarval M, Wellington M, Abranches J, Lemos JA. "The Spx regulator modulates stress responses and virulence in Enterococcus faecalis." Infection and immunity. 2012 Jul; 80(7):2265-75. Epub 2012 Apr 16.
Mitra S, Dolan K, Foster TH, Wellington M. "Imaging morphogenesis of Candida albicans during infection in a live animal." Journal of biomedical optics. 2010 15(1):010504.
2009 Oct
Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH. "Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa." Infection and immunity. 2009 Oct; 77(10):4446-54. Epub 2009 Aug 03.
2009 Aug
Dolan K, Montgomery S, Bucchiet B, Didone L, Wellington M, Krysan DJ. "Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization." Antimicrobial agents and chemotherapy. 2009 Aug; 53(8):3337-46. Epub 2009 Jun 01.
2009 Jan
Wellington M, Dolan K, Krysan DJ. "Live Candida albicans suppresses production of reactive oxygen species in phagocytes." Infection and immunity. 2009 Jan; 77(1):405-13. Epub 2008 Nov 03.
Oberholzer CM, Wellington M. "Serologic diagnosis of infectious diseases in the adolescent." Adolescent Medicine: State of the Art Reviews. 2008; 19: 135-48.
2007 Oct
Wellington M, Dolan K, Haidaris CG. "Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition." FEMS immunology and medical microbiology. 2007 Oct; 51(1):70-83. Epub 2007 Jul 04.
Wellington M, Kabir MA, Rustchenko E. "5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans." Mycologia. 2006 98(3):393-8.
2005 Dec
Wellington MA, Bonnez W. "Consultation with the specialist: genital warts." Pediatrics in review. 2005 Dec; 26(12):467-71.
2005 Jan 15
Wellington M, Rustchenko E. "5-Fluoro-orotic acid induces chromosome alterations in Candida albicans." Yeast (Chichester, England). 2005 Jan 15; 22(1):57-70.
2004 Jun
Wang YK, Das B, Huber DH, Wellington M, Kabir MA, Sherman F, Rustchenko E. "Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicans." Yeast (Chichester, England). 2004 Jun; 21(8):685-702.
2003 Dec
Wellington M, Bliss JM, Haidaris CG. "Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment." Infection and immunity. 2003 Dec; 71(12):7228-31.
2003 Oct
Bliss JM, Wellington M, Gigliotti F. "Antifungal pharmacotherapy for neonatal candidiasis." Seminars in perinatology. 2003 Oct; 27(5):365-74.
2002 Feb
Wellington M, Hall CB. "Pacifier as a risk factor for acute otitis media." Pediatrics. 2002 Feb; 109(2):351-2; author reply 353.
2001 Oct
Wellington M, Gigliotti F. "Update on antifungal agents." The Pediatric infectious disease journal. 2001 Oct; 20(10):993-5.


Krysan DJ, Wellington M, Steinbach WJ. "Feigin and Cherry's Textbook of Pediatric Infectious Diseases". Feigin and Cherry's Textbook of Pediatric Infectious Diseases. Cherry J, Harrison GJ, Kaplan S, Peter J, Hotez PJ, Steinbach, WJ. Philadelphia: Saunders Elsevier, 2014. 2846-52
Wellington M. "Typhoid fever and Salmonella infections". Pediatric Clinical Advisor. Garfunkel LC, Kaczorowski J, Christy C. St. Louis, MO: Mosby, Inc., 2007. 507-508
Wellington M. "Discitis". Pediatric Clinical Advisor. Garfunkel LC, Kaczorowski J, Christy C. St. Louis, MO: Mosby, Inc., 2007. 173
Wellington, M.. "Typhoid fever and Salmonella infections.". Pediatric Clinical Advisor. Garfunkel, L.C.; Kaczorowski, J.; Christy, C.. St. Louis: Mosby, Inc., 2002. 659-660