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Melanie A. Wellington, M.D., Ph.D.

Pediatrics

Clinical Interests

Infectious Diseases

Contact Information

Phone Numbers

Administrative: (585) 275-5944

Appointment: (585) 275-5944

Fax: (585) 273-1104

Office: (585) 275-5944

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Dr. Wellington is a board certified specialist in Pediatric Infectious Diseases. Her clinical focus is to provide care for children with or at risk for serious infections. When not caring for patients, Dr. Wellington performs research investigating how the body defends itself against fungal infections.

Professional Background

Dr. Wellington received her undergraduate degree in Biology at Brown University. She then went to Duke University, where she earned a Masters of Science in Cell Biology and her MD. She then came to Rochester where she completed a residency in Pediatrics. After her residency, Dr. Wellington worked for a year in Gallup, NM, as an attending pediatrician with the Indian Health Service and the Navajo Nation. She then returned to Rochester, where she combined her fellowship training in Pediatric Infectious Diseases with graduate studies, leading to her earning a PhD in Microbiology and Immunology. Her current research efforts grew out of her graduate work, and she is now serving as an Assistant Professor in the Division of Infectious Diseases in the Department of Pediatrics.

Research

Dr. Wellington's research interests are: 1) Host defense against infection with Candida 2) Fungal infections in children 3) Infections in the immunocompromised host. Candida is the most common cause of invasive fungal infection. Most individuals are colonized with Candida, but healthy individuals rarely develop disease from the organism. Candida does cause serious disease in patients who are immunocompromised because of malignancies, AIDS, congenital immunodeficiency disorders, or who are receiving medications that inhibit the immune response. Candida disease is extremely difficult to treat and has a high rate of mortality. Therefore, new modalities, such as the use of anti-Candida antibodies are being investigated. However, very little is known about how antibodies function to protect individuals from infection. The focus of Dr. Wellington's laboratory is to investigate how the immune response to Candida is affected by the presence of anti-Candida antibodies. The major area of investigation is the interaction of phagocytes with Candida. These investigations include characterization of the mechanisms through which antibody enhances the phagocyte response to the organism. In addition to antibody, receptors on the phagocyte surface that recognize pathogen associated molecular patterns may play an important role in activating the anti-Candida response. The ability of phagocytes to respond appropriately to Candida is important for activation of innate and adaptive immune responses to Candida and may lead to protection from the development of Candida disease. We expect these studies to lead to a better understanding of host-fungal interactions, which will allow us to improve the care of patients at risk for Candida disease.

Credentials

Faculty Appointments

Specialties

  • Pediatric Infectious Diseases - American Board of Pediatrics
  • Pediatrics - American Board of Pediatrics

Education

1994
MS | Duke University
Biology

1990
ScB | Brown University
Biology

2005
PhD | University of Rochester School of Medicine and Dentistry
Microbiology and Immunology

1995
MD | Duke University School of Medicine
Medicine

Post-doctoral Training & Residency

07/01/1995 - 06/30/1996
Internship in Pediatrics at University of Rochester Medical Center

07/01/1996 - 06/30/1998
Residency in Pediatrics at University of Rochester Medical Center

08/01/1999 - 06/30/2003
Fellowship in Pediatrics: Pediatric Infectious Diseases at University of Rochester Medical Center

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Awards

2008
Junior Faculty/Post-doctoral Fellow Travel Award
Sponsor: American Society for Microbiology Conference

2007 - 2008
Morning Report MVP Award
Location: Golisano Children's Hospital at Strong

2006 - 2007
Morning Report MVP Award
Sponsor: Golisano Children's Hospital at Strong

2006 - 2007
Strong Children's Research Center Research Development Award
Sponsor: Golisano Children's Hospital at Strong

2005 - 2005
Young Investigator Award, FEBS Advanced Lecture Course
Location: La Colle sur Loup, France

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Publications

Journal Articles

2/17/2017
Chang YL, Yu SJ, Heitman J, Wellington M, Chen YL. "New facets of antifungal therapy." Virulence.. 2017 Feb 17; 8(2):222-236. Epub 2016 Nov 07.

12/2016
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. "The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis." Antimicrobial agents and chemotherapy.. 2016 Dec 0; 60(12):7115-7127. Epub 2016 Nov 21.

6/2014
Krysan DJ, Sutterwala FS, Wellington M. "Catching fire: Candida albicans, macrophages, and pyroptosis." PLoS pathogens.. 2014 Jun 0; 10(6):e1004139. Epub 2014 Jun 26.

Books & Chapters

2014
Chapter Title: Feigin and Cherry's Textbook of Pediatric Infectious Diseases
Book Title: Feigin and Cherry's Textbook of Pediatric Infectious Diseases
Author List: Krysan DJ, Wellington M, Steinbach WJ
Edited By: Cherry J, Harrison GJ, Kaplan S, Peter J, Hotez PJ, Steinbach, WJ
Published By: Saunders Elsevier2014 in Philadelphia

2007
Chapter Title: Typhoid fever and Salmonella infections
Book Title: Pediatric Clinical Advisor
Author List: Wellington M
Edited By: Garfunkel LC, Kaczorowski J, Christy C
Published By: Mosby, Inc.2007 in St. Louis, MO

2007
Chapter Title: Discitis
Book Title: Pediatric Clinical Advisor
Author List: Wellington M
Edited By: Garfunkel LC, Kaczorowski J, Christy C
Published By: Mosby, Inc.2007 in St. Louis, MO

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