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Zheng-Gen Jin, Ph.D.


Showing all 40 journal articles & 0 books available

Journal Articles

Zhang S, Kim JY, Xu S, Liu H, Yin M, Koroleva M, Guo J, Pei X, Jin ZG. "Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ." Proceedings of the National Academy of Sciences of the United States of America.. 2020 Mar 3; 117(9):4792-4801. Epub 2020 Feb 19.

Luo J, Jin FQ, Yin M, Jin ZG. "Regulation of SRF protein stability by an autophagy-dependent pathway." Biochemical and biophysical research communications.. 2020 Jan 8; 521(2):279-284. Epub 2019 Oct 23.

Xu S, Xu Y, Liu P, Zhang S, Liu H, Slavin S, Kumar S, Koroleva M, Luo J, Wu X, Rahman A, Pelisek J, Jo H, Si S, Miller CL, Jin ZG. "The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis." European heart journal.. 2019 Aug 1; 40(29):2398-2408.

Xu S, Jin ZG. "Hutchinson-Gilford Progeria Syndrome: Cardiovascular Pathologies and Potential Therapies." Trends in biochemical sciences.. 2019 Jul; 44(7):561-564. Epub 2019 Apr 26.

Liu H, Zhang S, Xu S, Koroleva M, Small EM, Jin ZG. "Myofibroblast-specific YY1 promotes liver fibrosis." Biochemical and biophysical research communications.. 2019 Jun 30; 514(3):913-918. Epub 2019 May 10.

Xu S, Kamato D, Little PJ, Nakagawa S, Pelisek J, Jin ZG. "Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics." Pharmacology & therapeutics.. 2019 Apr; 196:15-43. Epub 2018 Nov 13.

Niu N, Xu S, Xu Y, Little PJ, Jin ZG. "Targeting Mechanosensitive Transcription Factors in Atherosclerosis." Trends in pharmacological sciences.. 2019 Apr; 40(4):253-266. Epub 2019 Feb 28.

Lyu Q, Xu S, Lyu Y, Choi M, Christie CK, Slivano OJ, Rahman A, Jin ZG, Long X, Xu Y, Miano JM. "stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4." Proceedings of the National Academy of Sciences of the United States of America.. 2019 Jan 8; 116(2):546-555. Epub 2018 Dec 24.

Xu S, Pelisek J, Jin ZG. "Atherosclerosis Is an Epigenetic Disease." Trends in endocrinology and metabolism : TEM.. 2018 Nov; 29(11):739-742. Epub 2018 May 10.

Zhao F, Anderson C, Karnes S, Zhou Q, Ma J, Jin ZG, Bhattacharjee PS, Wang S. "Expression, regulation and function of miR-126 in the mouse choroid vasculature." Experimental eye research.. 2018 May; 170:169-176. Epub 2018 Mar 01.

Xu S, Xu Y, Yin M, Zhang S, Liu P, Koroleva M, Si S, Little PJ, Pelisek J, Jin ZG. "Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects." Theranostics.. 2018 8(11):3007-3021. Epub 2018 Apr 30.

Xu Y, Xu S, Liu P, Koroleva M, Zhang S, Si S, Jin ZG. "Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis." Journal of the American Heart Association.. 2017 Nov 30; 6(12)Epub 2017 Nov 30.

Xu Y, Liu P, Xu S, Koroleva M, Zhang S, Si S, Jin ZG. "Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells." Scientific reports.. 2017 Jul 27; 7(1):6686. Epub 2017 Jul 27.

Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM. "Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice." Proceedings of the National Academy of Sciences of the United States of America.. 2017 Mar 28; 114(13):E2739-E2747. Epub 2017 Mar 14.

Deng H, Fung G, Qiu Y, Wang C, Zhang J, Jin ZG, Luo H. "Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Infection." Frontiers in cellular and infection microbiology.. 2017 7:85. Epub 2017 Mar 16.

Xu S, Koroleva M, Yin M, Jin ZG. "Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells." Translational research : the journal of laboratory and clinical medicine.. 2016 Oct; 176:18-28.e2. Epub 2016 May 26.

Xu S, Bai P, Jin ZG. "Sirtuins in Cardiovascular Health and Diseases." Trends in endocrinology and metabolism : TEM.. 2016 Oct; 27(10):677-678. Epub 2016 Jul 22.

Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, Morrell CN, Zhang DX, Fisher EA, Jin ZG. "A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis." Oncotarget.. 2016 Jun 21; 7(25):37622-37635.

Xu S, Yin M, Koroleva M, Mastrangelo MA, Zhang W, Bai P, Little PJ, Jin ZG. "SIRT6 protects against endothelial dysfunction and atherosclerosis in mice." Aging.. 2016 May; 8(5):1064-82.

Xu S, Ha CH, Wang W, Xu X, Yin M, Jin FQ, Mastrangelo M, Koroleva M, Fujiwara K, Jin ZG. "PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling." Cellular signalling.. 2016 Mar; 28(3):117-124. Epub 2015 Dec 17.

Liu Z, Xu S, Huang X, Wang J, Gao S, Li H, Zhou C, Ye J, Chen S, Jin ZG, Liu P. "Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1)." British journal of pharmacology.. 2015 Dec; 172(23):5661-75. Epub 2015 Feb 27.

Deng H, Fung G, Shi J, Xu S, Wang C, Yin M, Hou J, Zhang J, Jin ZG, Luo H. "Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2015 Nov; 29(11):4523-31. Epub 2015 Jul 16.

Wang W, Xu S, Yin M, Jin ZG. "Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis." International journal of cardiology.. 2015 Feb 15; 181:180-4. Epub 2014 Oct 24.

Kwon IS, Wang W, Xu S, Jin ZG. "Histone deacetylase 5 interacts with Krüppel-like factor 2 and inhibits its transcriptional activity in endothelium." Cardiovascular research.. 2014 Oct 1; 104(1):127-37. Epub 2014 Aug 05.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. "Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1." Circulation research.. 2012 Jan 6; 110(1):59-70. Epub 2011 Nov 10.

Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng GS, Jin ZG. "Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis." Arteriosclerosis, thrombosis, and vascular biology.. 2011 May; 31(5):1016-23. Epub 2011 Mar 03.

Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG. "PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy." Proceedings of the National Academy of Sciences of the United States of America.. 2010 Aug 31; 107(35):15467-72. Epub 2010 Aug 17.

Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I. "Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells." Antioxidants & redox signaling.. 2010 Jun 15; 12(12):1355-69.

Wang W, Ha CH, Jhun BS, Wong C, Jain MK, Jin ZG. "Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." Blood.. 2010 Apr 8; 115(14):2971-9. Epub 2009 Dec 30.

Ha CH, Jin ZG. "Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis." Molecules and cells.. 2009 Jul 31; 28(1):1-5. Epub 2009 Jul 20.

Ha CH, Jhun BS, Kao HY, Jin ZG. "VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis." Arteriosclerosis, thrombosis, and vascular biology.. 2008 Oct; 28(10):1782-8. Epub 2008 Jul 10.

Xu X, Jhun BS, Ha CH, Jin ZG. "Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation." Endocrinology.. 2008 Aug; 149(8):4183-92. Epub 2008 May 01.

Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. "VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 Jul; 22(7):2297-310. Epub 2008 Feb 08.

Satoh K, Matoba T, Suzuki J, O'Dell MR, Nigro P, Cui Z, Mohan A, Pan S, Li L, Jin ZG, Yan C, Abe J, Berk BC. "Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation." Circulation.. 2008 Jun 17; 117(24):3088-98. Epub 2008 Jun 09.

Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, McKinsey TA, Olson EN, Jin ZG. "Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis." The Journal of biological chemistry.. 2008 May 23; 283(21):14590-9. Epub 2008 Mar 10.

Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L. "VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism." The Journal of biological chemistry.. 2008 May 9; 283(19):13491-9. Epub 2008 Mar 20.

Ha CH, Bennett AM, Jin ZG. "A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor." The Journal of biological chemistry.. 2008 Mar 14; 283(11):7261-70. Epub 2008 Jan 07.

Ha, C.H., Jhun, B.S., Kao, H.Y., Jin, Z.G. ""VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiongenesis."". Arterioscler Thromb Vasc Biol. 2008; .

Xu X, Ha CH, Wong C, Wang W, Hausser A, Pfizenmaier K, Olson EN, McKinsey TA, Jin ZG. "Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy." Arteriosclerosis, thrombosis, and vascular biology.. 2007 Nov; 27(11):2355-62. Epub 2007 Sep 06.

Suzuki J, Jin ZG, Meoli DF, Matoba T, Berk BC. "Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells." Circulation research.. 2006 Mar 31; 98(6):811-7. Epub 2006 Mar 09.