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Lin Gan, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-1510

Fax: (585) 276-2432

Research Labs

Gan Lab

Lab: (585) 273-1513

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Biography

Research

The mammalian retina and inner ear are two of the most common places of genetic diseases that cause blindness and deafness due to the degeneration of retinal and inner ear neurons. In order to understand the disease processes, it is very crucial to elucidate the fundamental mechanisms regulating the normal development and maintenance of these neurons at the molecular level. My research is centered on identifying genes required for neuron differentiation and survival, investigating the genetic pathways involved in these processes, and developing therapies for blindness and deafness via gene therapy and stem cell replacement. I am currently investigating the roles of three classes of transcription factors (TFs), the basic helix-loop-helix (bHLH), POU-homeodomain (POU-HD), and LIM-domain TFs, in the formation and maintenance of mouse retina and inner ear. Using homologous recombination in mouse embryonic stem (ES) cells to mutate these TF genes, I have shown that these TFs function in a cascade to regulate the differentiation of neuronal progenitor cells into specific types of neurons and to regulate the maturation and survival of post-differentiation neurons.

Credentials

Faculty Appointments

Education

1985
BS | China - Non-Medical School
Biochemistry, All Other

1992
PhD | U Tex-Houstn Grad Sch Biomd Sc
Biochemistry, All Other

Awards

2011 - 2011
Research to Prevent Blindness Senior Scientific Investigator Award
Sponsor: Research to Prevent Blindness

1999 - 2003
Rosanne H. Silbermann Fellow
Sponsor: Silbermann Foundation

1985
CUSBEA (China-United States Biochemistry and Molecular Biology Examination and Administration) Program Scholarship
Sponsor: Ministry of Education
Location: China

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Publications

Journal Articles

8/2017
Ding Q, Balasubramanian R, Zheng D, Liang G, Gan L. "Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh." Molecular neurobiology.. 2017 Aug 0; 54(6):4414-4420. Epub 2016 Jun 27.

4/20/2016
Xu J, Wu XS, Sheng J, Zhang Z, Yue HY, Sun L, Sgobio C, Lin X, Peng S, Jin Y, Gan L, Cai H, Wu LG. "?-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2016 Apr 20; 36(16):4408-14.

3/25/2016
Huang H, Yang X, Bao M, Cao H, Miao X, Zhang X, Gan L, Qiu M, Zhang Z. "Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence." The Journal of biological chemistry.. 2016 Mar 25; 291(13):7107-18. Epub 2016 Jan 29.

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