Dirk P. Bohmann, Ph.D.

Dirk P. Bohmann, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Administrative: (585) 273-1440
Fax: (585) 273-1450
Office: (585) 273-1446
Lab: (585) 273-2904

Journal Articles

Showing all 88 journal articles available.

2016 May
Chatterjee N, Tian M, Spirohn K, Boutros M, Bohmann D. "Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein." PLoS genetics. 2016 May; 12(5):e1006072. Epub 2016 May 27.
2016 Feb 25
Li X, Chatterjee N, Spirohn K, Boutros M, Bohmann D. "Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes." Scientific reports. 2016 Feb 25; 6:21455. Epub 2016 Feb 25.
2015 Nov
Pitoniak A, Bohmann D. "Mechanisms and functions of Nrf2 signaling in Drosophila." Free radical biology & medicine. 2015 Nov; 88(Pt B):302-13. Epub 2015 Jun 25.
2014 May
Bohmann D, Dhillon P. "Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann." Disease models & mechanisms. 2014 May; 7(5):499-502.
2013 Oct
Tsakiri EN, Sykiotis GP, Papassideri IS, Terpos E, Dimopoulos MA, Gorgoulis VG, Bohmann D, Trougakos IP. "Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging." Aging cell. 2013 Oct; 12(5):802-13. Epub 2013 Jun 28.
2013 Aug
Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D. "Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes." Aging cell. 2013 Aug; 12(4):554-62. Epub 2013 May 16.
2013 Jun
Tsakiri EN, Sykiotis GP, Papassideri IS, Gorgoulis VG, Bohmann D, Trougakos IP. "Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 Jun; 27(6):2407-20. Epub 2013 Mar 01.
2013 Apr 24
Barone MC, Bohmann D. "Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining." Journal of visualized experiments : JoVE. 2013 Apr 24; (74):e50339. Epub 2013 Apr 24.
Chatterjee N, Bohmann D. "A versatile ?C31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture." PloS one. 2012 7(4):e34063. Epub 2012 Apr 11.
2011 Sep
Barone MC, Sykiotis GP, Bohmann D. "Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease." Disease models & mechanisms. 2011 Sep; 4(5):701-7. Epub 2011 Jun 30.
2011 Apr 22
Schreck I, Al-Rawi M, Mingot JM, Scholl C, Diefenbacher ME, O'Donnell P, Bohmann D, Weiss C. "c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK." Biochemical and biophysical research communications. 2011 Apr 22; 407(4):735-40. Epub 2011 Mar 31.
2011 Feb 4
Hochmuth CE, Biteau B, Bohmann D, Jasper H. "Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila." Cell stem cell. 2011 Feb 4; 8(2):188-99.
2011 Jan
Sykiotis GP, Habeos IG, Samuelson AV, Bohmann D. "The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation." Current opinion in clinical nutrition and metabolic care. 2011 Jan; 14(1):41-8.
Kriete A, Lechner M, Clearfield D, Bohmann D. "Computational systems biology of aging." Wiley interdisciplinary reviews. Systems biology and medicine. 2011 3(4):414-28. Epub 2010 Dec 31.
2010 Mar 9
Sykiotis GP, Bohmann D. "Stress-activated cap'n'collar transcription factors in aging and human disease." Science signaling. 2010 Mar 9; 3(112):re3. Epub 2010 Mar 09.
2010 Jan 19
Wang Q, Uhlirova M, Bohmann D. "Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis." Developmental cell. 2010 Jan 19; 18(1):157-64.
2010 Jan
Sekyrova P, Bohmann D, Jindra M, Uhlirova M. "Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis." Development. 2010 Jan; 137(1):141-50.
Wu H, Wang MC, Bohmann D. "JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy." Mechanisms of development. 2009 126(8-9):624-37. Epub 2009 Jun 18.
2008 Jan
Sykiotis GP, Bohmann D. "Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila." Developmental cell. 2008 Jan; 14(1):76-85.
2007 Jan 24
Luo X, Puig O, Hyun J, Bohmann D, Jasper H. "Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation." The EMBO journal. 2007 Jan 24; 26(2):380-90. Epub 2006 Dec 21.
Sykiotis, G.P.; Bohmann, D. "Stress-Activated Protein Kinase Signaling in Drosophila". Topics in Current Genetics. 2007; .
2006 Nov 15
Uhlirova M, Bohmann D. "JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila." The EMBO journal. 2006 Nov 15; 25(22):5294-304. Epub 2006 Nov 02.
2006 Nov
Hyun J, Bécam I, Yanicostas C, Bohmann D. "Control of G2/M transition by Drosophila Fos." Molecular and cellular biology. 2006 Nov; 26(22):8293-302. Epub 2006 Sep 11.
2006 Feb
Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D. "JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis." Developmental dynamics : an official publication of the American Association of Anatomists. 2006 Feb; 235(2):427-34.
2006 Jan 1
Miotto B, Sagnier T, Berenger H, Bohmann D, Pradel J, Graba Y. "Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis." Genes & development. 2006 Jan 1; 20(1):101-12.
2005 Sep 13
Uhlirova M, Jasper H, Bohmann D. "Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model." Proceedings of the National Academy of Sciences of the United States of America. 2005 Sep 13; 102(37):13123-8. Epub 2005 Sep 06.
2005 Jul
Hyun J, Jasper H, Bohmann D. "DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs." Molecular and cellular biology. 2005 Jul; 25(13):5590-8.
2005 Jun 2
Etter PD, Narayanan R, Navratilova Z, Patel C, Bohmann D, Jasper H, Ramaswami M. "Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons." BMC neuroscience. 2005 Jun 2; 6:39. Epub 2005 Jun 02.
2005 Apr 8
Wang MC, Bohmann D, Jasper H. "JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling." Cell. 2005 Apr 8; 121(1):115-25.
2005 Mar
Letsou A, Bohmann D. "Small flies--big discoveries: nearly a century of Drosophila genetics and development." Developmental dynamics : an official publication of the American Association of Anatomists. 2005 Mar; 232(3):526-8.
Etter,P. D.; Narayanan,R.; Navratilova,Z.; Patel,C.; Bohmann,D.; Jasper,H.; Ramaswami,M.;. "Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons". BMC neuroscience [computer file]. 2005; 6(1): 39. Link
2004 Jun 18
Portman DS, Bohmann D. "Toward the computable transcriptome." Molecular cell. 2004 Jun 18; 14(6):693-4.
2004 Mar 10
Su C, Gao G, Schneider S, Helt C, Weiss C, O'Reilly MA, Bohmann D, Zhao J. "DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway." The EMBO journal. 2004 Mar 10; 23(5):1133-43. Epub 2004 Feb 19.
2004 Feb
Weiss C, Bohmann D. "Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis." Cell cycle. 2004 Feb; 3(2):111-3.
2003 Nov
Wang MC, Bohmann D, Jasper H. "JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila." Developmental cell. 2003 Nov; 5(5):811-6.
2003 Jul 15
Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D. "JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun." The EMBO journal. 2003 Jul 15; 22(14):3686-95.
2002 Nov
Jasper H, Bohmann D. "Drosophila innate immunity: a genomic view of pathogen defense." Molecular cell. 2002 Nov; 10(5):967-9.
2002 Oct
Jasper H, Benes V, Atzberger A, Sauer S, Ansorge W, Bohmann D. "A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye." Developmental cell. 2002 Oct; 3(4):511-21.
2002 Sep 19
Gallo A, Cuozzo C, Esposito I, Maggiolini M, Bonofiglio D, Vivacqua A, Garramone M, Weiss C, Bohmann D, Musti AM. "Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation." Oncogene. 2002 Sep 19; 21(42):6434-45.
2002 Aug
Lafarga M, Berciano MT, Pena E, Mayo I, Castaño JG, Bohmann D, Rodrigues JP, Tavanez JP, Carmo-Fonseca M. "Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome." Molecular biology of the cell. 2002 Aug; 13(8):2771-82.
2002 Jul
Ciapponi L, Bohmann D. "An essential function of AP-1 heterodimers in Drosophila development." Mechanisms of development. 2002 Jul; 115(1-2):35-40.
2002 Jul
Gritzan U, Weiss C, Brennecke J, Bohmann D. "Transrepression of AP-1 by nuclear receptors in Drosophila." Mechanisms of development. 2002 Jul; 115(1-2):91-100.
2002 Feb 1
Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D. "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription." The EMBO journal. 2002 Feb 1; 21(3):451-60.
2001 Oct
Jasper H, Benes V, Schwager C, Sauer S, Clauder-Münster S, Ansorge W, Bohmann D. "The genomic response of the Drosophila embryo to JNK signaling." Developmental cell. 2001 Oct; 1(4):579-86.
2001 Jul
Leppä S, Eriksson M, Saffrich R, Ansorge W, Bohmann D. "Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells." Molecular and cellular biology. 2001 Jul; 21(13):4369-78.
2001 Jun 15
Ciapponi L, Jackson DB, Mlodzik M, Bohmann D. "Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites." Genes & development. 2001 Jun 15; 15(12):1540-53.
2001 Apr 30
Kockel L, Homsy JG, Bohmann D. "Drosophila AP-1: lessons from an invertebrate." Oncogene. 2001 Apr 30; 20(19):2347-64.
2001 Apr
Mihaly J, Kockel L, Gaengel K, Weber U, Bohmann D, Mlodzik M. "The role of the Drosophila TAK homologue dTAK during development." Mechanisms of development. 2001 Apr; 102(1-2):67-79.
2000 Jan 17
Barilá D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G. "A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK." The EMBO journal. 2000 Jan 17; 19(2):273-81.
1999 Dec
Valcárcel R, Weber U, Jackson DB, Benes V, Ansorge W, Bohmann D, Mlodzik M. "Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development." Journal of cell science. 1999 Dec; 112 ( Pt 23):4389-96.
1999 Nov 1
Leppä S, Bohmann D. "Diverse functions of JNK signaling and c-Jun in stress response and apoptosis." Oncogene. 1999 Nov 1; 18(45):6158-62.
1999 Sep
Zeitlinger J, Bohmann D. "Thorax closure in Drosophila: involvement of Fos and the JNK pathway." Development. 1999 Sep; 126(17):3947-56.
1998 Aug 3
Leppä S, Saffrich R, Ansorge W, Bohmann D. "Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation." The EMBO journal. 1998 Aug 3; 17(15):4404-13.
1997 Dec 15
Zeitlinger J, Kockel L, Peverali FA, Jackson DB, Mlodzik M, Bohmann D. "Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants." The EMBO journal. 1997 Dec 15; 16(24):7393-401.
1997 Nov
Isaksson A, Peverali FA, Kockel L, Mlodzik M, Bohmann D. "The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development." Mechanisms of development. 1997 Nov; 68(1-2):59-67.
1997 Nov
Riesgo-Escovar JR, Hafen E, Hou XS, Goldstein ES, Perrimon N, Glise B, Noselli S, Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D. "Connecting up the pathways in Drosophila development." Trends in cell biology. 1997 Nov; 7(11):421-2.
1997 Jul 1
Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D. "Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways." Genes & development. 1997 Jul 1; 11(13):1748-58.
1997 May 1
Kockel L, Vorbrüggen G, Jäckle H, Mlodzik M, Bohmann D. "Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development." Genes & development. 1997 May 1; 11(9):1140-7.
1997 Apr 15
Eresh S, Riese J, Jackson DB, Bohmann D, Bienz M. "A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction." The EMBO journal. 1997 Apr 15; 16(8):2014-22.
1997 Jan 17
Musti AM, Treier M, Bohmann D. "Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases." Science. 1997 Jan 17; 275(5298):400-2.
1996 Oct
Musti AM, Treier M, Peverali FA, Bohmann D. "Differential regulation of c-Jun and JunD by ubiquitin-dependent protein degradation." Biological chemistry. 1996 Oct; 377(10):619-24.
1996 Aug 8
Isaksson A, Musti AM, Bohmann D. "Ubiquitin in signal transduction and cell transformation." Biochimica et biophysica acta. 1996 Aug 8; 1288(1):F21-9.
1996 Aug 1
Peverali FA, Isaksson A, Papavassiliou AG, Plastina P, Staszewski LM, Mlodzik M, Bohmann D. "Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation." The EMBO journal. 1996 Aug 1; 15(15):3943-50.
1995 Dec 1
Treier M, Bohmann D, Mlodzik M. "JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye." Cell. 1995 Dec 1; 83(5):753-60.
1995 Aug 19
Davydov IV, Bohmann D, Krammer PH, Li-Weber M. "Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter." Gene. 1995 Aug 19; 161(2):271-5.
1995 Aug 1
Jenkins F, Cockerill PN, Bohmann D, Shannon MF. "Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells." The Journal of immunology : official journal of the American Association of Immunologists. 1995 Aug 1; 155(3):1240-51.
1995 May 1
Papavassiliou AG, Treier M, Bohmann D. "Intramolecular signal transduction in c-Jun." The EMBO journal. 1995 May 1; 14(9):2014-9.
1994 Sep 23
Bohmann D, Ellis MC, Staszewski LM, Mlodzik M. "Drosophila Jun mediates Ras-dependent photoreceptor determination." Cell. 1994 Sep 23; 78(6):973-86.
1994 Sep 9
Treier M, Staszewski LM, Bohmann D. "Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain." Cell. 1994 Sep 9; 78(5):787-98.
1994 Jun 17
Goldberg Y, Treier M, Ghysdael J, Bohmann D. "Repression of AP-1-stimulated transcription by c-Ets-1." The Journal of biological chemistry. 1994 Jun 17; 269(24):16566-73.
1993 Oct 25
de Martin R, Cowled PA, Smith SE, Papavassiliou AG, Sorrentino V, Philipson L, Bohmann D. "Structure and regulation of the growth arrest-specific (gas-1) promoter." The Journal of biological chemistry. 1993 Oct 25; 268(30):22788-93.
1993 Apr 11
Smith SE, Papavassiliou AG, Bohmann D. "Different TRE-related elements are distinguished by sets of DNA-binding proteins with overlapping sequence specificity." Nucleic acids research. 1993 Apr 11; 21(7):1581-5.
1992 Dec 18
Papavassiliou AG, Treier M, Chavrier C, Bohmann D. "Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun." Science. 1992 Dec 18; 258(5090):1941-4.
1992 Dec 1
Papavassiliou AG, Chavrier C, Bohmann D. "Phosphorylation state and DNA-binding activity of c-Jun depend on the intracellular concentration of binding sites." Proceedings of the National Academy of Sciences of the United States of America. 1992 Dec 1; 89(23):11562-5.
1992 Aug 25
Papavassiliou AG, Bohmann D. "Optimization of the signal-to-noise ratio in south-western assays by using lipid-free BSA as blocking reagent." Nucleic acids research. 1992 Aug 25; 20(16):4365-6.
1992 Aug
Smith SE, Bohmann D. "Functional dissection of AP-1 transcription factors using the Gal4 adaptor assay." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1992 Aug; 3(8):523-9.
1992 Jun
Papavassiliou AG, Bohmann K, Bohmann D. "Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors." Analytical biochemistry. 1992 Jun; 203(2):302-9.
1990 Nov
Bohmann D. "Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression." Cancer cells (Cold Spring Harbor, N.Y. : 1989). 1990 Nov; 2(11):337-44.
1989 Nov 17
Bohmann D, Tjian R. "Biochemical analysis of transcriptional activation by Jun: differential activity of c- and v-Jun." Cell. 1989 Nov 17; 59(4):709-17.
1988 May 20
Rauscher FJ, Cohen DR, Curran T, Bos TJ, Vogt PK, Bohmann D, Tjian R, Franza BR. "Fos-associated protein p39 is the product of the jun proto-oncogene." Science. 1988 May 20; 240(4855):1010-6.
1988 Mar 11
Bos TJ, Bohmann D, Tsuchie H, Tjian R, Vogt PK. "v-jun encodes a nuclear protein with enhancer binding properties of AP-1." Cell. 1988 Mar 11; 52(5):705-12.
Bohmann D, Admon A, Turner DR, Tjian R. "Transcriptional regulation by the AP-1 family of enhancer-binding proteins: a nuclear target for signal transduction." Cold Spring Harbor symposia on quantitative biology. 1988 53 Pt 2:695-700.
1987 Dec 4
Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R. "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1." Science. 1987 Dec 4; 238(4832):1386-92.
1987 Aug 25
Tebb G, Bohmann D, Mattaj IW. "Only two of the four sites of interaction with nuclear factors within the Xenopus U2 gene promoter are necessary for efficient transcription." Nucleic acids research. 1987 Aug 25; 15(16):6437-53.
Bohmann D, Keller W, Dale T, Schöler HR, Tebb G, Mattaj IW. "A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes." Nature. 1987 325(6101):268-72.
1986 Dec 1
Schlokat U, Bohmann D, Schöler H, Gruss P. "Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements." The EMBO journal. 1986 Dec 1; 5(12):3251-8.
1985 Dec 1
Shaw PE, Bohmann D, Sergeant A. "The SV40 enhancer influences viral late transcription in vitro and in vivo but not on replicating templates." The EMBO journal. 1985 Dec 1; 4(12):3247-52.
1984 Dec 15
Sergeant A, Bohmann D, Zentgraf H, Weiher H, Keller W. "A transcription enhancer acts in vitro over distances of hundreds of base-pairs on both circular and linear templates but not on chromatin-reconstituted DNA." Journal of molecular biology. 1984 Dec 15; 180(3):577-600.