Skip to main content
Explore URMC

URMC Logo

menu

Hu Peng, B.Med., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Biography

Research

Dr. Peng's research interests are multifunctional extracellular matrix protein hensin, which plays an important role in adaptation of intercalated cells during metabolic acidosis. Hensin have also been associated with epithelial differentiation, and tumor suppression. Although hensin was founded ten years ago, full-length hensin cloning and expression is still not available. So far, hensin can only be obtained from natural source such as , cell medium, cell lysates, etc. Recombinant expression and purification of hensin is an essential and key step for systematic investigating its structure, function, signal transduction pathway and towards the evaluation of its therapeutically potential.

Dr. Peng's some research aims are as follows:
1) Cloning, sequencing, and expression full-lenth hensin gene as well as its different domains, such as SRCR, Zp, and CUB domain.
2) Structural and functional analysis of hensin. Investigating the mechanisms of hensin polymerizing in ECM and determining other proteins interacting with hensin such as cyclophilins, galectin-3, integrins and so on.
3) Investigating hensin signaling pathway.

Credentials

Faculty Appointments

Education

1986
MD | Xi'an Medical University
Medicine

1991
MSc | Xi'an Medical University
Microbiology and Immunology

1994
PhD | Institute of Virology, Chinese Academy of Preventive Medicine
Molecular Virology and Immunology

Awards

1995
Awarded Chinese Academy of Preventive Medicine Grant
Location: Beijing, China

1988
" Teacher of the Year ", Xi'an Medical University
Location: Xi'an, China

Publications

Journal Articles

11/1/2017
Peng H, Purkerson JM, Schwaderer AL, Schwartz GJ. "Metabolic acidosis stimulates the production of the antimicrobial peptide cathelicidin in rabbit urine." American journal of physiology. Renal physiology.. 2017 Nov 1; 313(5):F1061-F1067. Epub 2017 Jul 26.

10/26/2015
Schwartz GJ, Gao X, Tsuruoka S, Purkerson JM, Peng H, D'Agati V, Picard N, Eladari D, Al-Awqati Q. "SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution." The Journal of clinical investigation.. 2015 Oct 26; 125(12):4365-74. Epub 2015 Oct 26.

7/1/2013
Vijayakumar S, Peng H, Schwartz GJ. "Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate-recognition domain." American journal of physiology. Renal physiology.. 2013 Jul 1; 305(1):F90-9. Epub 2013 May 08.

VIEW ALL PUBLICATIONS