Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy (Nat Med. 2005 Mar;11(3):277-83.).
The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in diseases of the central nervous system (CNS), such as traumatic injury (spinal cord and traumatic brain injury) and neurodegenerative diseases (Parkinsons Disease, Multiple sclerosis).
We have identified distinct astrocyte populations that demonstrate different functional properties with respect to their ability to promote injury repair upon transplantation into the injured nervous system. While one type shows little benefit and may even cause neuropathic pain syndrome, the other remodels the injured host tissue, enables axon outgrowth and extensive functional recovery (J Biol 2006 Apr 27, 5(3):7; J Biol 2008 Sep 19;7(7):245). As a prerequisite for the transition to the clinic we are analyzing the factors secreted by these astrocytes and have now derived homologous astrocyte populations from human precursor cells. (PLoS One. 2011 Mar 2;6(3)).
BS | Julius-Maximillian Univ.
M.Sc. | Julius-Maximillian Univ.
PhD | LICR Univ. Colllege
Molecular & Cellular Biology
European Molecular Biology Organization, Practical Course:
"Mouse Developmental Genetics"
Course supervisor: Prof. P. Gruss
Max-Planck Institute, Göttingen
1986 - 1987
Scholarship of the University Würzburg:
Departments of Molecular Genetics and Neurobiology
State University of New York, Albany, U.S.A.
Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M. "Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia." Glia.. 2016 Feb 0; 64(2):227-39. Epub 2015 Oct 15.
Campbell A, Krupp B, Bushman J, Noble M, Pröschel C, Mayer-Pröschel M. "A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden." Human molecular genetics.. 2015 Nov 15; 24(22):6331-49. Epub 2015 Aug 26.
Noble M, Mayer-Pröschel M, Li Z, Dong T, Cui W, Pröschel C, Ambeskovic I, Dietrich J, Han R, Miranda Yang Y, Folts C, Stripay J, Chen HY, Stevens BM. "Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment." Free radical biology & medicine.. 2015 Feb 0; 79:300-23. Epub 2014 Dec 04.
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