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Robert H. Dworkin, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-8214

Fax: (585) 244-7271

Faculty Appointments

Biography

Professional Background

1. Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the Food and Drug Administration (FDA) [www.acttion.org]
2. Special Government Employee, FDA
3. Professional Advisory Board, American Chronic Pain Association
4. Associate Editor, Pain
5. Editorial Boards: Journal of Pain; Canadian Journal of Pain; Current Pain and Headache Reports

Research

My major research interests are (1) methodologic aspects of analgesic clinical trials and (2) treatment and prevention of chronic neuropathic and musculoskeletal pain. The primary focus of our current research involves the identification of factors that increase the assay sensitivity of clinical trials to detect differences between an active and a control or comparison treatment. In ongoing studies, we are examining the relationships between clinical trial results and their research designs, patient characteristics, and outcome measures. This program of research and other efforts to improve the efficiency and informativeness of analgesic clinical trials are being conducted under the auspices of the ACTTION public-private partnership with the FDA. I have also been very interested in the identification of risk factors for the development of chronic pain. One of our major results has been that patients with greater acute pain are more likely to develop chronic pain. This suggests that attenuating acute pain might prevent chronic pain, and an additional focus of my research has involved developing approaches to test this hypothesis.

Current Funding (as Principal Investigator)
1. FDA, U01 FD005936-01 (9/15/16-8/31/21): Analgesic, anesthetic, and addiction clinical trial translations, innovations, opportunities, and networks (ACTTION) public-private partnership
2. FDA, HHSF223201400191C (9/30/14-9/29/19): Analysis of FDA clinical trial data to improve assay sensitivity and informativeness of analgesic clinical trials
3. NIH/NIAMS, R01 AR059102-01A (9/1/11-7/31/18): Combined behavioral and analgesic trial for fibromyalgia (COMBAT-FM)

Credentials

Education

1971
BA | University of Pennsylvania
Psychology, Sociology

1977
PhD | Harvard University
Psychology

Awards

2018
Founders Award
Sponsor: American Academy of Pain Medicine

2018
Raymond Houde Lectureship Award
Sponsor: Eastern Pain Association

2015
Mitchell B. Max Award for Neuropathic Pain
Sponsor: American Academy of Neurology

2014
John and Emma Bonica Public Service Award
Sponsor: American Pain Society

2011
John J. Bonica Award
Sponsor: Eastern Pain Association

2008
Frontiers in Pain Lecture
Sponsor: McGill University

2007
Advisory Committee Service Award
Sponsor: US Food and Drug Administration

2007
Gunn-Loke Lecture
Sponsor: University of Washington

2005
Wilbert Fordyce Clinical Investigator Award
Sponsor: American Pain Society

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Publications

Journal Articles

5/17/2018
Ward DS, Williams MR, Berkenbosch JW, Bhatt M, Carlson D, Chappell P, Clark RM, Constant I, Conway A, Cravero J, Dahan A, Dexter F, Dionne R, Dworkin RH, Gan TJ, Gozal D, Green S, Irwin MG, Karan S, Kochman M, Lerman J, Lightdale JR, Litman RS, Mason KP, Miner J, O'Connor RE, Pandharipande P, Riker RR, Roback MG, Sessler DI, Sexton A, Tobin JR, Turk DC, Twersky RS, Urman RD, Weiss M, Wunsch H, Zhao-Wong A. "Evaluating Patient-Centered Outcomes in Clinical Trials of Procedural Sedation, Part 2 Safety: Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research Recommendations." Anesthesia and analgesia.. 2018 May 17; Epub 2018 May 17.

5/15/2018
Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. "Transition to chronic pain: opportunities for novel therapeutics." Nature reviews. Neuroscience.. 2018 May 15; Epub 2018 May 15.

5/2018
Smith SM, Dworkin RH. "Prospective clinical trial registration: not sufficient, but always necessary." Anaesthesia.. 2018 May 0; 73(5):538-541. Epub 2018 Jan 02.

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