Yuhchyau Chen, M.D., Ph.D.

Yuhchyau Chen, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 647
Rochester, NY 14642

Fax: (585) 275-1531

Journal Articles

Showing all 68 journal articles available.

Lee SO; Yang X; Duan S; Tsai Y; Strojny LR; Keng P; Chen Y. "IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer". Oncotarget. 2016; in press.
2015 Sep 29
Duan S, Tsai Y, Keng P, Chen Y, Lee SO, Chen Y. "IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules." Oncotarget. 2015 Sep 29; 6(29):27651-60.
2015 Aug 11
Qiu H, Katz AW, Chowdhry AK, Usuki KY, Singh DP, Metcalfe S, Cheruvu P, Chen Y, Okunieff P, Milano MT. "Stereotactic Body Radiotherapy for Lung Metastases from Colorectal Cancer: Prognostic Factors for Disease Control and Survival." American journal of clinical oncology. 2015 Aug 11; Epub 2015 Aug 11.
2015 Jun 1
Constine LS, Chen Y. "Philip Rubin, MD, FASTRO: Reflections on a Radiation Oncology Pioneer." International journal of radiation oncology, biology, physics. 2015 Jun 1; 92(2):193-5.
2015 May
Dertinger SD, Avlasevich SL, Bemis JC, Chen Y, MacGregor JT. "Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples." Environmental and molecular mutagenesis. 2015 May; 56(4):366-77. Epub 2014 Nov 20.
2015 Apr
Singh DP, Bylund KC, Matloubieh A, Mazloom A, Gray A, Sidhu R, Barrette L, Chen Y. "Is there a subset of patients with recurrent cancer in the vagina who are not candidates for interstitial brachytherapy that can be treated with multichannel vaginal brachytherapy using graphic optimization?" Journal of contemporary brachytherapy. 2015 Apr; 7(2):135-41. Epub 2015 Apr 28.
Chen Y, Zhang F, Tsai Y, Yang X, Yang L, Duan S, Wang X, Keng P, Lee SO. "IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation." Radiation oncology. 2015 10:227. Epub 2015 Nov 14.
2014 Apr
Singh D, Chen Y, Hare MZ, Usuki KY, Zhang H, Lundquist T, Joyce N, Schell MC, Milano MT. "Local control rates with five-fraction stereotactic body radiotherapy for oligometastatic cancer to the lung." Journal of thoracic disease. 2014 Apr; 6(4):369-74.
2014 Jan
Chen Y, Nowak I, Huang J, Keng PC, Sun H, Xu H, Wei G, Lee SO. "Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2014 Jan; 9(1):50-8.
Qiu H; Hare M; Chen Y. "A case report of long-term survival of metastatic extraskeletal myxoid chondrosarcoma treated with surgery and hypofractionated radiotherapy." J Radiother Pract. 2014; in press.
2013 Sep
Huang CK, Lai KP, Luo J, Tsai MY, Kang HY, Chen Y, Lee SO, Chang C. "Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells." Stem cell research. 2013 Sep; 11(2):938-50. Epub 2013 Jun 10.
2013 Jun 7
Yang DR, Ding XF, Luo J, Shan YX, Wang R, Lin SJ, Li G, Huang CK, Zhu J, Chen Y, Lee SO, Chang C. "Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer." The Journal of biological chemistry. 2013 Jun 7; 288(23):16476-83. Epub 2013 Apr 22.
2013 May
Liesveld J, Pawlowski J, Chen R, Hyrien O, Debolt J, Becker M, Phillips G, Chen Y. "Clinical factors affecting engraftment and transfusion needs in SCT: a single-center retrospective analysis." Bone marrow transplantation. 2013 May; 48(5):691-7. Epub 2012 Oct 22.
Chen Y, Moon J, Pandya KJ, Lau DH, Kelly K, Hirsch FR, Gaspar LE, Redman M, Gandara DR. "A Pilot Study (SWOG S0429) of Weekly Cetuximab and Chest Radiotherapy for Poor-Risk Stage III Non-Small Cell Lung Cancer." Frontiers in oncology. 2013 3:219. Epub 2013 Aug 28.
Liesveld JL, Phillips GL, Becker M, Constine LS, Friedberg J, Andolina JR, Milner LA, Debolt J, Smudzin T, Hyrien O, Erickson-Miller CL, Johnson BM, Dawson KL, Chen Y. "A phase 1 trial of eltrombopag in patients undergoing stem cell transplantation after total body irradiation." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 19(12):1745-52. Epub 2013 Oct 08.
Zhang H, Messing EM, Travis LB, Hyrien O, Chen R, Milano MT, Chen Y. "Age and Racial Differences among PSA-Detected (AJCC Stage?T1cN0M0) Prostate Cancer in the U.S.: A Population-Based Study of 70,345 Men." Frontiers in oncology. 2013 3:312. Epub 2013 Dec 23.
2012 Nov 15
Milano MT, Zhang H, Usuki KY, Singh DP, Chen Y. "Definitive radiotherapy for stage I nonsmall cell lung cancer: a population-based study of survival." Cancer. 2012 Nov 15; 118(22):5572-9. Epub 2012 Apr 27.
2012 Sep
Sun H, Tsai Y, Nowak I, Liesveld J, Chen Y. "Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis." Stem cell research. 2012 Sep; 9(2):77-86. Epub 2012 May 14.
2012 Jul
Reid R, Bennett JM, Becker M, Chen Y, Milner L, Phillips Ii GL, Liesveld J. "Use of eltrombopag, a thrombopoietin receptor agonist, in post-transplantation thrombocytopenia." American journal of hematology. 2012 Jul; 87(7):743-5. Epub 2012 May 10.
2012 Mar 1
Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, Chen Y. "Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patients." Cancer. 2012 Mar 1; 118(5):1276-87. Epub 2011 Jul 19.
2012 Jan
Schuette W, Krzakowski MJ, Massuti B, Otterson GA, Lizambri R, Wei H, Berger DP, Chen Y. "Randomized phase II study of palifermin for reducing dysphagia in patients receiving concurrent chemoradiotherapy for locally advanced unresectable non-small cell lung cancer." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2012 Jan; 7(1):157-64.
Milano MT, Peterson CR, Zhang H, Singh DP, Chen Y. "Second primary lung cancer after head and neck squamous cell cancer: population-based study of risk factors." Head & neck. 2012 34(12):1782-8. Epub 2012 Feb 09.
2011 Aug 1
Chen Y, Pandya KJ, Hyrien O, Keng PC, Smudzin T, Anderson J, Qazi R, Smith B, Watson TJ, Feins RH, Johnstone DW. "Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancer." International journal of radiation oncology, biology, physics. 2011 Aug 1; 80(5):1358-64. Epub 2010 Aug 12.
2011 Jul 10
Le QT, Kim HE, Schneider CJ, Muraközy G, Skladowski K, Reinisch S, Chen Y, Hickey M, Mo M, Chen MG, Berger D, Lizambri R, Henke M. "Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study." Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011 Jul 10; 29(20):2808-14. Epub 2011 Jun 13.
2011 Apr
Peslak SA, Wenger J, Bemis JC, Kingsley PD, Frame JM, Koniski AD, Chen Y, Williams JP, McGrath KE, Dertinger SD, Palis J. "Sublethal radiation injury uncovers a functional transition during erythroid maturation." Experimental hematology. 2011 Apr; 39(4):434-45. Epub 2011 Feb 01.
2011 Jan 10
Sun H, Tsai Y, Nowak I, Dertinger SD, Wu JH, Chen Y. "Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture." Mutation research. 2011 Jan 10; 718(1-2):38-43. Epub 2010 Nov 04.
Cheruvu P, Metcalfe SK, Metcalfe J, Chen Y, Okunieff P, Milano MT. "Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer." Radiation oncology. 2011 6:80. Epub 2011 Jun 30.
2010 Jul 1
Tucker SL, Jin H, Wei X, Wang S, Martel MK, Komaki R, Liu HH, Mohan R, Chen Y, Cox JD, Liao Z. "Impact of toxicity grade and scoring system on the relationship between mean lung dose and risk of radiation pneumonitis in a large cohort of patients with non-small cell lung cancer." International journal of radiation oncology, biology, physics. 2010 Jul 1; 77(3):691-8. Epub 2009 Oct 14.
2010 Feb
Metcalfe SK, Milano MT, Bylund K, Smudzin T, Rubin P, Chen Y. "Split-course palliative radiotherapy for advanced non-small cell lung cancer." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2010 Feb; 5(2):185-90.
2010 Feb
Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, Dertinger SD. "Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model." Health physics. 2010 Feb; 98(2):218-27.
2009 Sep 1
Chawla S, Chen Y, Katz AW, Muhs AG, Philip A, Okunieff P, Milano MT. "Stereotactic body radiotherapy for treatment of adrenal metastases." International journal of radiation oncology, biology, physics. 2009 Sep 1; 75(1):71-5. Epub 2009 Feb 26.
2009 Sep
Roscoe JA, Bushunow P, Jean-Pierre P, Heckler CE, Purnell JQ, Peppone LJ, Chen Y, Ling MN, Morrow GR. "Acupressure bands are effective in reducing radiation therapy-related nausea." Journal of pain and symptom management. 2009 Sep; 38(3):381-9. Epub 2009 Mar 28.
2009 Aug 1
Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y. "Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials." International journal of radiation oncology, biology, physics. 2009 Aug 1; 74(5):1580-91. Epub 2009 Jun 17.
2009 Aug 1
Albain KS, Swann RS, Rusch VW, Turrisi AT, Shepherd FA, Smith C, Chen Y, Livingston RB, Feins RH, Gandara DR, Fry WA, Darling G, Johnson DH, Green MR, Miller RC, Ley J, Sause WT, Cox JD. "Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial." Lancet. 2009 Aug 1; 374(9687):379-86. Epub 2009 Jul 24.
2009 Jun
Jin H, Tucker SL, Liu HH, Wei X, Yom SS, Wang S, Komaki R, Chen Y, Martel MK, Mohan R, Cox JD, Liao Z. "Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2009 Jun; 91(3):427-32. Epub 2008 Oct 18.
2009 Jun
Milano MT, Chen Y, Katz AW, Philip A, Schell MC, Okunieff P. "Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2009 Jun; 91(3):301-6. Epub 2009 Mar 28.
2009 Apr 30
Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. "Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age." Mutation research. 2009 Apr 30; 675(1-2):77-80. Epub 2009 Feb 11.
Sun H, Dertinger SD, Hyrien O, Wu JH, Chen Y. "Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro." Mutation research. 2009 680(1-2):49-55. Epub 2009 Sep 26.
2008 Sep
Okunieff P, Chen Y, Maguire DJ, Huser AK. "Molecular markers of radiation-related normal tissue toxicity." Cancer metastasis reviews. 2008 Sep; 27(3):363-74.
2008 Jun 1
Chen Y, Pandya KJ, Feins R, Johnstone DW, Watson T, Smudzin T, Keng PC. "Toxicity profile and pharmacokinetic study of a phase I low-dose schedule-dependent radiosensitizing paclitaxel chemoradiation regimen for inoperable non-small-cell lung cancer." International journal of radiation oncology, biology, physics. 2008 Jun 1; 71(2):407-13. Epub 2007 Dec 31.
2008 Jun
Zhang H, Hyrien O, Pandya KJ, Keng PC, Chen Y. "Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2008 Jun; 3(6):563-8.
2007 Jan 10
Dertinger SD, Miller RK, Brewer K, Smudzin T, Torous DK, Roberts DJ, Avlasevich SL, Bryce SM, Sugunan S, Chen Y. "Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage." Mutation research. 2007 Jan 10; 626(1-2):111-9. Epub 2006 Oct 23.
Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y. "Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry." Mutation research. 2007 634(1-2):119-25. Epub 2007 Jul 05.
Chambers MS, Jones CU, Biel MA, Weber RS, Hodge KM, Chen Y, Holland JM, Ship JA, Vitti R, Armstrong I, Garden AS, Haddad R. "Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia." International journal of radiation oncology, biology, physics. 2007 69(5):1369-76. Epub 2007 Sep 12.
2006 Apr 1
Chen Y, Trotti A, Coleman CN, Machtay M, Mirimanoff RO, Hay J, O'brien PC, El-Gueddari B, Salvajoli JV, Jeremic B. "Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation." International journal of radiation oncology, biology, physics. 2006 Apr 1; 64(5):1442-51. Epub 2006 Jan 18.
2005 May 1
Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. "Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis." International journal of radiation oncology, biology, physics. 2005 May 1; 62(1):260-6.
2005 May 1
Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. "Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors." International journal of radiation oncology, biology, physics. 2005 May 1; 62(1):273-8.
Okunieff P, Fenton B, Chen Y. "Past, present, and future of oxygen in cancer research." Advances in experimental medicine and biology. 2005 566:213-22.
2004 Feb
Chen Y, Okunieff P. "Radiation and third-generation chemotherapy." Hematology/oncology clinics of North America. 2004 Feb; 18(1):55-80.
Dertinger SD, Camphausen K, Macgregor JT, Bishop ME, Torous DK, Avlasevich S, Cairns S, Tometsko CR, Menard C, Muanza T, Chen Y, Miller RK, Cederbrant K, Sandelin K, Pontén I, Bolcsfoldi G. "Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood." Environmental and molecular mutagenesis. 2004 44(5):427-35.
2003 Aug
Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I. "Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth." American journal of clinical oncology. 2003 Aug; 26(4):S103-9.
2003 Jul
Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. "The biological basis of a comprehensive grading system for the adverse effects of cancer treatment." Seminars in radiation oncology. 2003 Jul; 13(3):182-8.
2003 Mar
Chen Y, Pandya K, Keng PC, Johnstone D, Li J, Lee YJ, Smudzin T, Okunieff P. "Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines." Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 Mar; 9(3):969-75.
Dertinger SD, Chen Y, Miller RK, Brewer KJ, Smudzin T, Torous DK, Hall NE, Olvany KA, Murante FG, Tometsko CR. "Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans." Mutation research. 2003 542(1-2):77-87.
Chen Y, Okunieff P, Ahrendt SA. "Translational research in lung cancer." Seminars in surgical oncology. 2003 21(3):205-19.
2002 Jan
Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. "Radiation pneumonitis and early circulatory cytokine markers." Seminars in radiation oncology. 2002 Jan; 12(1 Suppl 1):26-33.
2001 Oct
Chen Y, Pandya K, Keng PP, Feins R, Raubertas R, Smudzin T, Rosenblatt J, Okunieff P. "Schedule-dependent pulsed paclitaxel radiosensitization for thoracic malignancy." American journal of clinical oncology. 2001 Oct; 24(5):432-7.
2001 Mar 1
Chen Y, Rubin P, Williams J, Hernady E, Smudzin T, Okunieff P. "Circulating IL-6 as a predictor of radiation pneumonitis." International journal of radiation oncology, biology, physics. 2001 Mar 1; 49(3):641-8.
Chen Y, Taghian AG, Rosenberg AE, O'Connell J, Okunieff P, Suit HD. "Predictive value of histologic tumor necrosis after radiation." International journal of cancer. Journal international du cancer. 2001 96(6):334-40.
1999 Jun
Okunieff P, Barrett AJ, Phang SE, Li A, Constine LS, Williams JP, Rubin P, Wang X, Wu T, Chen Y, Ding I. "Circulating basic fibroblast growth factor declines during Cy/TBI bone marrow transplantation." Bone marrow transplantation. 1999 Jun; 23(11):1117-21.
Poot M, Hoehn H, Kubbies M, Grossmann A, Chen Y, Rabinovitch PS. "Cell-cycle analysis using continuous bromodeoxyuridine labeling and Hoechst 33358-ethidium bromide bivariate flow cytometry." Methods in cell biology. 1994 41:327-40.
1992 Jan
Chen Y, Richards TL, Izenberg S, Golden RN, Williams DL, Nelson JA, Steen RG. "In vivo phosphorus NMR spectroscopy of skin using a crossover surface coil." Magnetic resonance in medicine. 1992 Jan; 23(1):46-54.
1990 Oct
Chen YY, Rabinovitch PS. "Mitogen response and cell cycle kinetics of Swiss 3T3 cells in defined medium: differences from human fibroblasts and effects of cell density." Experimental cell research. 1990 Oct; 190(2):145-50.
1990 Jul
Chen YY, Rabinovitch PS. "Altered cell cycle responses to insulin-like growth factor I, but not platelet-derived growth factor and epidermal growth factor, in senescing human fibroblasts." Journal of cellular physiology. 1990 Jul; 144(1):18-25.
Poot M, Hoehn H, Kubbies M, Grossmann A, Chen YC, Rabinovitch PS. "Cell cycle analysis using continuous bromodeoxyuridine labeling and Hoechst 33258-ethidium bromide bivariate flow cytometry." Methods in cell biology. 1990 33:185-98.
1989 Jul
Chen Y, Rabinovitch PS. "Platelet-derived growth factor, epidermal growth factor, and insulin-like growth factor I regulate specific cell-cycle parameters of human diploid fibroblasts in serum-free culture." Journal of cellular physiology. 1989 Jul; 140(1):59-67.
1988 Sep
Raghu G, Chen YY, Rusch V, Rabinovitch PS. "Differential proliferation of fibroblasts cultured from normal and fibrotic human lungs." The American review of respiratory disease. 1988 Sep; 138(3):703-8.
1988 Feb
Rabinovitch PS, Kubbies M, Chen YC, Schindler D, Hoehn H. "BrdU-Hoechst flow cytometry: a unique tool for quantitative cell cycle analysis." Experimental cell research. 1988 Feb; 174(2):309-18.


Singh D; Bylund K; Chen Y. "Translational Research in Lung Cancer". Advances in Radiation Oncology in Lung Cancer. Jeremic B. Heidelberg: Springer-Verlag GmbH, 2011. 793-808
Chen Y, Gandara D. "Molecular Staging of Non-small Cell Lung Cancer". Tumors of the Chest: Biology Diagnosis and Management. Syrigos KN, Nutting C, Roussos C. Berlin Heidelberg New York: Springer-Verlag, 2006.
Chen Y. "Translational Research in Radiation Oncology of Lung Cancer.". Advances in Radiation Oncology in Lung Cancer. Medical Radiology- Diagnostic Ima. Jeremic B, Baert AL, Brady LW, Heilmann HP, Molls M, Sartor K. : Springer, 2005.
Hinkle AS, Proukou C, Chen Y. "Pulmonary Effects of Antineoplastic Therapy". Survivors of Childhood Cancer: Assessment and Management. Schwartz C, Hobbie W, Constine L, Ruccione K. Berlin Heidelberg New York: Springer-Verlag GmbH & Co.KG, 2005.
Alan C, Aisenberg T, Chen Y. "The Lymphomas.". Clinical Radiation Oncology: Indications, Techniques, and Results. Wang CC. New York: Wiley-Liss, 2000.
Okunieff P, Sundararaman S, Chen Y. "Biology of large dose per fraction radiation therapy.". Current Clinical Oncology: Intraoperative Irradiation-Techniques and Results. Gunderson LL. Totowa, NJ: Humanna Press, Inc., 1999. 25-46
Rubin P, Chen Y, Brasacchio R. "Staging and Classification of Cancer: A Unified Approach.". Principles and Practice of Radiation Oncology. Perez CA, Brady LW. Philadelphia: Lippincott-Raven, 1997.