Robert Stanley Freeman, Ph.D.

Robert Stanley Freeman, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Journal Articles

Showing all 39 journal articles available.

2012 May
Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. "JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death." Neurobiology of disease. 2012 May; 46(2):393-401. Epub 2012 Feb 14.
2011 Feb 3
Guo H, Barrett TM, Zhong Z, Fernandez JA, Griffin JH, Freeman RS, Zlokovic BV. "Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway." Molecular neurodegeneration. 2011 Feb 3; 6:13. Epub 2011 Feb 03.
2010 Nov 17
Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. "Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Nov 17; 30(46):15521-34.
2009 Jul 7
Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS. "Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL." Science signaling. 2009 Jul 7; 2(78):ra33. Epub 2009 Jul 07.
2009 May
Lomb DJ, Desouza LA, Franklin JL, Freeman RS. "Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons." Molecular pharmacology. 2009 May; 75(5):1198-209. Epub 2009 Feb 09.
2009 Apr 23
Guo Y, Schoell MC, Freeman RS. "The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL)." Oncogene. 2009 Apr 23; 28(16):1864-74. Epub 2009 Mar 23.
2008 Dec
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I. "Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury." Annals of the New York Academy of Sciences. 2008 Dec; 1147:383-94.
2008 Jul
Barone MC, Desouza LA, Freeman RS. "Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity." Journal of neurochemistry. 2008 Jul; 106(2):734-45. Epub 2008 Apr 14.
2007 Dec
Lomb DJ, Straub JA, Freeman RS. "Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation." Journal of neurochemistry. 2007 Dec; 103(5):1897-906. Epub 2007 Aug 30.
2007 Apr 27
Fu J, Menzies K, Freeman RS, Taubman MB. "EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability." The Journal of biological chemistry. 2007 Apr 27; 282(17):12410-8. Epub 2007 Mar 06.
2006 Jul 1
Brookes PS, Freeman RS, Barone MC. "A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress"." Free radical biology & medicine. 2006 Jul 1; 41(1):41-5. Epub 2006 Apr 01.
2005 Aug
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S. "Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer." Cancer cell. 2005 Aug; 8(2):155-67.
2005 Aug
Clifton DR, Rydkina E, Huyck H, Pryhuber G, Freeman RS, Silverman DJ, Sahni SK. "Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia rickettsii infection: regulation by nuclear transcription factor NF-kappaB." International journal of medical microbiology : IJMM. 2005 Aug; 295(4):267-78.
2005 Mar 14
Xie L, Johnson RS, Freeman RS. "Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1." The Journal of cell biology. 2005 Mar 14; 168(6):911-20.
2005 Feb
Freeman RS, Barone MC. "Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders." Current drug targets. CNS and neurological disorders. 2005 Feb; 4(1):85-92.
2005 Jan
Clifton DR, Rydkina E, Freeman RS, Sahni SK. "NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha." Infection and immunity. 2005 Jan; 73(1):155-65.
2004 Mar 11
Farhana L, Dawson MI, Huang Y, Zhang Y, Rishi AK, Reddy KB, Freeman RS, Fontana JA. "Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities." Oncogene. 2004 Mar 11; 23(10):1874-84.
Freeman RS, Burch RL, Crowder RJ, Lomb DJ, Schoell MC, Straub JA, Xie L. "NGF deprivation-induced gene expression: after ten years, where do we stand?" Progress in brain research. 2004 146:111-26.
2003 Sep
Besirli CG, Deckwerth TL, Crowder RJ, Freeman RS, Johnson EM. "Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons." Cell death and differentiation. 2003 Sep; 10(9):1045-58.
2003 Aug 31
Freeman RS, Hasbani DM, Lipscomb EA, Straub JA, Xie L. "SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases." Molecules and cells. 2003 Aug 31; 16(1):1-12.
2003 Apr
Straub JA, Lipscomb EA, Yoshida ES, Freeman RS. "Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death." Journal of neurochemistry. 2003 Apr; 85(2):318-28.
2002 Oct
Wolf G, Harendza S, Schroeder R, Wenzel U, Zahner G, Butzmann U, Freeman RS, Stahl RA. "Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20." Laboratory investigation; a journal of technical methods and pathology. 2002 Oct; 82(10):1305-17.
2001 Sep
Sarmiere PD, Freeman RS. "Analysis of the NF-kappa B and PI 3-kinase/Akt survival pathways in nerve growth factor-dependent neurons." Molecular and cellular neurosciences. 2001 Sep; 18(3):320-31.
2001 Feb 16
Lipscomb EA, Sarmiere PD, Freeman RS. "SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons." The Journal of biological chemistry. 2001 Feb 16; 276(7):5085-92. Epub 2000 Nov 01.
2000 Nov 3
Crowder RJ, Freeman RS. "Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal." The Journal of biological chemistry. 2000 Nov 3; 275(44):34266-71.
1999 Aug
Crowder RJ, Freeman RS. "The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt." Journal of neurochemistry. 1999 Aug; 73(2):466-75.
1999 Jul
Lipscomb EA, Sarmiere PD, Crowder RJ, Freeman RS. "Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons." Journal of neurochemistry. 1999 Jul; 73(1):429-32.
1998 Dec 15
Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS. "Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Dec 15; 18(24):10356-65.
1998 Apr 15
Crowder RJ, Freeman RS. "Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Apr 15; 18(8):2933-43.
1994 Dec
Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM. "Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis." The Journal of cell biology. 1994 Dec; 127(6 Pt 1):1717-27.
1994 Feb
Freeman RS, Estus S, Johnson EM. "Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death." Neuron. 1994 Feb; 12(2):343-55.
1993 Mar
Smith CJ, Johnson EM, Osborne P, Freeman RS, Neveu I, Brachet P. "NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro." Brain research. Molecular brain research. 1993 Mar; 17(3-4):328-34.
1993 Feb
Freeman RS, Estus S, Horigome K, Johnson EM. "Cell death genes in invertebrates and (maybe) vertebrates." Current opinion in neurobiology. 1993 Feb; 3(1):25-31.
1992 Feb
Freeman RS, Meyer AN, Li J, Donoghue DJ. "Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor." The Journal of cell biology. 1992 Feb; 116(3):725-35.
1991 Mar 5
Freeman RS, Donoghue DJ. "Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle." Biochemistry. 1991 Mar 5; 30(9):2293-302.
1991 Mar
Freeman RS, Ballantyne SM, Donoghue DJ. "Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe." Molecular and cellular biology. 1991 Mar; 11(3):1713-7.
1990 Aug
Freeman RS, Kanki JP, Ballantyne SM, Pickham KM, Donoghue DJ. "Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos." The Journal of cell biology. 1990 Aug; 111(2):533-41.
1989 Sep
Freeman RS, Donoghue DJ. "Transforming mutant v-mos protein kinases that are deficient in in vitro autophosphorylation." Molecular and cellular biology. 1989 Sep; 9(9):4087-90.
1989 Aug
Freeman RS, Pickham KM, Kanki JP, Lee BA, Pena SV, Donoghue DJ. "Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes." Proceedings of the National Academy of Sciences of the United States of America. 1989 Aug; 86(15):5805-9.


R. S. Freeman. "The cell cycle and neuronal cell death". Cell Death in Diseases of the Nervous System. V. Koliatsos and R. R. Ratan. Totowa, NJ: Humana Press Inc, 1998. 103-119
E. M. Johnson, Jr., E. B. Cornbrooks, T. L. Deckwerth, S. Estus, J. L. Franklin, R. S. Freeman, K. Horigome and P. A. Lampe. "Molecular mechanism of programmed cell death in the developing nervous system". Neuronal Cell Death and Repair. A. C. Cuello. Amsterdam: Elsevier Science Publishers, 1993. 23-31