Skip to main content
Explore URMC

URMC Logo

Jane M. Sottile, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 276-7698

Office: (585) 276-7690

Fax: (585) 276-1530

Research Labs

Biography

Jane Sottile is an Associate Professor of Medicine in the Aab Cardiovascular Research Institute. My laboratory is interested in understanding how tissues respond to injury, and the mechanisms that regulate the tissue repair process. In broad terms, my laboratory investigates 1) how blood vessels respond to injury, and 2) how abnormal tissue repair leads to fibrosis. One goal of our research is to understand the underlying events associated with vascular diseases, especially the vascular remodeling (the process by which blood vessels enlarge or contract) that occurs during hypertension, atherosclerosis, and following arterial injury. Our ultimate aim is to understand the response of vascular cells to injury, and to develop therapies based on regulating the activity of certain proteins to restore normal vascular function. Another goal of our research is to better understand the process of fibrosis. Fibrosis is a progressive and often fatal disease that can develop in many organ systems, including the heart, lungs and kidneys. During fibrosis, there is abnormal accumulation of proteins in the tissues, which contributes to impaired organ function. One goal of our research is to better understand the processes that control the development of fibrosis, and to develop reagents to inhibit the progression of fibrosis.

Research

Research Overview A precise balance between the deposition and degradation of extracellular matrix molecules, including collagen type I and fibronectin, is required for normal tissue function, and is a key component of normal tissue repair. The studies in my lab are focused on understanding the mechanisms that control extracellular matrix remodeling. Our data show that the extracellular matrix protein, fibronectin, plays a key role in controlling the deposition and stability of extracellular matrix proteins, including collagen I. Our data also demonstrate that the polymerization of fibronectin into the extracellular matrix regulates adhesion-dependent cell growth, cell contractility and cell migration. Agents that disrupt fibronectin polymerization trigger enhanced fibronectin and collagen I turnover; these agents also induce turnover of fibronectin in tissues. These data indicate that extracellular matrix turnover is regulated by fibronectin polymerization. Hence, agents that regulate fibronectin polymerization are likely to be crucial in controlling cell proliferation, migration, and extracellular matrix remodeling, all of which are key events that occur during vascular remodeling, wound healing, and fibrosis. We are currently studying the mechanisms by which fibronectin polymerization regulates extracellular matrix remodeling, cell growth, and cell migration using in vitro, ex vivo and in vivo approaches. These studies will provide important insights into factors that contribute to the development of fibrosis, and into mechanisms that could prevent the progression of fibrosis. These studies will also provide important insights into the complex interplay between smooth muscle cells and extracellular matrix, which plays a critical role in the development and progression of vascular disease.

Credentials

Faculty Appointments

Education

1979
BA | Marist College
Biology

1987
PhD | St Univ at Albany
Arts & Sciences

Awards

1989
Postdoctoral Individual National Research Service Award
Sponsor: NIH

1979
Valedictorian
Sponsor: Marist College
Location: Poughkeepsie, NY

Publications

Journal Articles

3/2015
Altrock E, Sens C, Wuerfel C, Vasel M, Kawelke N, Dooley S, Sottile J, Nakchbandi IA. "Inhibition of fibronectin deposition improves experimental liver fibrosis." Journal of hepatology.. 2015 Mar 0; 62(3):625-33. Epub 2014 Jun 16.

7/2009
Chiang HY, Korshunov VA, Serour A, Shi F, Sottile J. "Fibronectin is an important regulator of flow-induced vascular remodeling." Arteriosclerosis, thrombosis, and vascular biology.. 2009 Jul 0; 29(7):1074-9. Epub 2009 Apr 30.

7/15/2008
Shi F, Sottile J. "Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover." Journal of cell science.. 2008 Jul 15; 121(Pt 14):2360-71. Epub 2008 Jun 24.

Books & Chapters

2008
Chapter Title: Integrin Trafficking
Book Title: Cell Junctions: Adhesion, Development and Disease
Author List: LaFlamme, S.E., Shi, F., Sottile, J
Edited By: LaFlamme, S.E., and Kowalczyk, A.
Published By: Wiley-VCH2008 in Weinheim

VIEW ALL PUBLICATIONS